7,383 research outputs found
A new generation 99 line Matlab code for compliance Topology Optimization and its extension to 3D
Compact and efficient Matlab implementations of compliance Topology
Optimization (TO) for 2D and 3D continua are given, consisting of 99 and 125
lines respectively. On discretizations ranging from to
elements, the 2D version, named top99neo, shows speedups from
2.55 to 5.5 times compared to the well-known top88 code (Andreassen-etal 2011).
The 3D version, named top3D125, is the most compact and efficient Matlab
implementation for 3D TO to date, showing a speedup of 1.9 times compared to
the code of Amir-etal 2014, on a discretization with elements.
For both codes, improvements are due to much more efficient procedures for the
assembly and implementation of filters and shortcuts in the design update step.
The use of an acceleration strategy, yielding major cuts in the overall
computational time, is also discussed, stressing its easy integration within
the basic codes.Comment: 17 pages, 8 Figures, 4 Table
Lipidic cubic phase serial millisecond crystallography using synchrotron radiation.
Lipidic cubic phases (LCPs) have emerged as successful matrixes for the crystallization of membrane proteins.Moreover, the viscous LCP also provides a highly effective delivery medium for serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs). Here, the adaptation of this technology to perform serial millisecond crystallography (SMX) at more widely available synchrotron microfocus beamlines is described. Compared with conventional microcrystallography, LCP-SMX eliminates the need for difficult handling of individual crystals and allows for data collection at room temperature. The technology is demonstrated by solving a structure of the light-driven protonpump bacteriorhodopsin (bR) at a resolution of 2.4 A ° . The room-temperature structure of bR is very similar to previous cryogenic structures but shows small yet distinct differences in the retinal ligand and proton-transfer pathway
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