2,116 research outputs found
From 4D medical images (CT, MRI, and Ultrasound) to 4D structured mesh models of the left ventricular endocardium for patient-specific simulations
With cardiovascular disease (CVD) remaining the primary cause of death worldwide, early detection of CVDs becomes essential. The intracardiac flow is an important component of ventricular function, motion kinetics, wash-out of ventricular chambers, and ventricular energetics. Coupling between Computational Fluid Dynamics (CFD) simulations and medical images can play a fundamental role in terms of patient-specific diagnostic tools. From a technical perspective, CFD simulations with moving boundaries could easily lead to negative volumes errors and the sudden failure of the simulation. The generation of high-quality 4D meshes (3D in space + time) with 1-to-l vertex becomes essential to perform a CFD simulation with moving boundaries. In this context, we developed a semiautomatic morphing tool able to create 4D high-quality structured meshes starting from a segmented 4D dataset. To prove the versatility and efficiency, the method was tested on three different 4D datasets (Ultrasound, MRI, and CT) by evaluating the quality and accuracy of the resulting 4D meshes. Furthermore, an estimation of some physiological quantities is accomplished for the 4D CT reconstruction. Future research will aim at extending the region of interest, further automation of the meshing algorithm, and generating structured hexahedral mesh models both for the blood and myocardial volume
Accelerated Cardiac Diffusion Tensor Imaging Using Joint Low-Rank and Sparsity Constraints
Objective: The purpose of this manuscript is to accelerate cardiac diffusion
tensor imaging (CDTI) by integrating low-rankness and compressed sensing.
Methods: Diffusion-weighted images exhibit both transform sparsity and
low-rankness. These properties can jointly be exploited to accelerate CDTI,
especially when a phase map is applied to correct for the phase inconsistency
across diffusion directions, thereby enhancing low-rankness. The proposed
method is evaluated both ex vivo and in vivo, and is compared to methods using
either a low-rank or sparsity constraint alone. Results: Compared to using a
low-rank or sparsity constraint alone, the proposed method preserves more
accurate helix angle features, the transmural continuum across the myocardium
wall, and mean diffusivity at higher acceleration, while yielding significantly
lower bias and higher intraclass correlation coefficient. Conclusion:
Low-rankness and compressed sensing together facilitate acceleration for both
ex vivo and in vivo CDTI, improving reconstruction accuracy compared to
employing either constraint alone. Significance: Compared to previous methods
for accelerating CDTI, the proposed method has the potential to reach higher
acceleration while preserving myofiber architecture features which may allow
more spatial coverage, higher spatial resolution and shorter temporal footprint
in the future.Comment: 11 pages, 16 figures, published on IEEE Transactions on Biomedical
Engineerin
Patient-specific CFD simulation of intraventricular haemodynamics based on 3D ultrasound imaging
Background: The goal of this paper is to present a computational fluid dynamic (CFD) model with moving boundaries to study the intraventricular flows in a patient-specific framework. Starting from the segmentation of real-time transesophageal echocardiographic images, a CFD model including the complete left ventricle and the moving 3D mitral valve was realized. Their motion, known as a function of time from the segmented ultrasound images, was imposed as a boundary condition in an Arbitrary Lagrangian-Eulerian framework.
Results: The model allowed for a realistic description of the displacement of the structures of interest and for an effective analysis of the intraventricular flows throughout the cardiac cycle. The model provides detailed intraventricular flow features, and highlights the importance of the 3D valve apparatus for the vortex dynamics and apical flow.
Conclusions: The proposed method could describe the haemodynamics of the left ventricle during the cardiac cycle. The methodology might therefore be of particular importance in patient treatment planning to assess the impact of mitral valve treatment on intraventricular flow dynamics
Three-dimensional structure of the flow inside the left ventricle of the human heart
The laboratory models of the human heart left ventricle developed in the last
decades gave a valuable contribution to the comprehension of the role of the
fluid dynamics in the cardiac function and to support the interpretation of the
data obtained in vivo. Nevertheless, some questions are still open and new ones
stem from the continuous improvements in the diagnostic imaging techniques.
Many of these unresolved issues are related to the three-dimensional structure
of the left-ventricular flow during the cardiac cycle. In this paper we
investigated in detail this aspect using a laboratory model. The ventricle was
simulated by a flexible sack varying its volume in time according to a
physiologically shaped law. Velocities measured during several cycles on series
of parallel planes, taken from two orthogonal points of view, were combined
together in order to reconstruct the phase averaged, three-dimensional velocity
field. During the diastole, three main steps are recognized in the evolution of
the vortical structures: i) straight propagation in the direction of the long
axis of a vortex-ring originated from the mitral orifice; ii) asymmetric
development of the vortex-ring on an inclined plane; iii) single vortex
formation. The analysis of three-dimensional data gives the experimental
evidence of the reorganization of the flow in a single vortex persisting until
the end of the diastole. This flow pattern seems to optimize the cardiac
function since it directs velocity towards the aortic valve just before the
systole and minimizes the fraction of blood residing within the ventricle for
more cycles
Advances in computational modelling for personalised medicine after myocardial infarction
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide. Determining which patients will experience heart failure and sudden cardiac death after an acute MI is notoriously difficult for clinicians. The extent of heart damage after an acute MI is informed by cardiac imaging, typically using echocardiography or sometimes, cardiac magnetic resonance (CMR). These scans provide complex data sets that are only partially exploited by clinicians in daily practice, implying potential for improved risk assessment. Computational modelling of left ventricular (LV) function can bridge the gap towards personalised medicine using cardiac imaging in patients with post-MI. Several novel biomechanical parameters have theoretical prognostic value and may be useful to reflect the biomechanical effects of novel preventive therapy for adverse remodelling post-MI. These parameters include myocardial contractility (regional and global), stiffness and stress. Further, the parameters can be delineated spatially to correspond with infarct pathology and the remote zone. While these parameters hold promise, there are challenges for translating MI modelling into clinical practice, including model uncertainty, validation and verification, as well as time-efficient processing. More research is needed to (1) simplify imaging with CMR in patients with post-MI, while preserving diagnostic accuracy and patient tolerance (2) to assess and validate novel biomechanical parameters against established prognostic biomarkers, such as LV ejection fraction and infarct size. Accessible software packages with minimal user interaction are also needed. Translating benefits to patients will be achieved through a multidisciplinary approach including clinicians, mathematicians, statisticians and industry partners
Recommended from our members
Deep learning for cardiac image segmentation: A review
Deep learning has become the most widely used approach for cardiac image segmentation in recent years. In this paper, we provide a review of over 100 cardiac image segmentation papers using deep learning, which covers common imaging modalities including magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound (US) and major anatomical structures of interest (ventricles, atria and vessels). In addition, a summary of publicly available cardiac image datasets and code repositories are included to provide a base for encouraging reproducible research. Finally, we discuss the challenges and limitations with current deep learning-based approaches (scarcity of labels, model generalizability across different domains, interpretability) and suggest potential directions for future research
An Image Based Computational Fluid Dynamics Study of Mitral Valve. A novel Approach to Assess the Mitral Valve, from Physiology to Surgical Practice
Mitral valve disease is the second most frequent valve disease requiring surgery. The aim of our study was to develop through a computational fluid dynamics a method to study the mitral valve from Pathophysiology to mitral valve regurgitation undergone surgical repair. As a first stage, we performed computational fluid dynamic (CFD) simulations in the left ventricle, left atrium and aortic root, with a resistive immersed method, a turbulence model, and with imposed systolic wall motion reconstructed from Cine-Magnetic Resonance Imaging (MRI) images, which allowed us to segment also the mitral valve. For the regurgitant scenarios we considered an increase of the heart rate and a dilation of the left ventricle. Our results highlighted that mitral varve regurgitation (MVR) gave rise to regurgitant jets through the mitral orifice impinging against the atrial walls and scratching against the mitral valve leading to high values of wall shear stresses (WSSs) with respect to the healthy case. CFD with prescribed wall motion and immersed mitral valve revealed to be an effective tool to quantitatively describe hemodynamics in case of MVR and to compare different regurgitant scenarios. Our findings highlighted in particular the presence of transition to turbulence in the atrium and allowed us to quantify some important cardiac indices such as cardiac output and WSS. After validation of the model, we performed a computational image-based study of blood dynamics in the whole left heart, both in a healthy subject and in a patient with MVR. We elaborated dynamic cine-MRI images with the aim of reconstructing the geometry and the corresponding motion of left ventricle, left atrium, mitral and aortic valves, and aortic root of the subjects. This allowed us to prescribe such motion to computational blood dynamics simulations where, for the first time, the whole left heart motion of the subject is considered, allowing us to obtain reliable subject-specific information. The final aim was to investigate and compare between the subjects the occurrence of turbulence and the risk of hemolysis and of thrombi formation. In particular, we modeled blood with the Navier-Stokes equations in the Arbitrary Lagrangian-Eulerian framework, with a Large Eddy Simulation model to describe the transition to turbulence and a resistive method to manage the valve dynamics, and we used a Finite Elements discretization implemented in an in-house code for the numerical solution. Our results highlighted that the regurgitant jet in the MVR case gave rise to a large amount of transition to turbulence in the left atrium resulting in a higher risk of formation of hemolysis. Moreover, MVR promoted a more complete washout of stagnant flows in the left atrium during the systolic phase and in the left ventricle apex during diastole. This work put the base for a new clinical approach to the mitral valve such as the analysis and the comparison of different surgical techniques of the diseased mitral valve undergone a surgical repair
- …