7,261 research outputs found

    What is the best time to tweet a journal article? Quasi-randomized controlled trial

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    Introdu√ß√£o: Os usu√°rios das plataformas de m√≠dia social s√£o frequentemente encorajados a agendar suas postagens para aumentar o n√ļmero de leitores e o engajamento. Nosso objetivo foi descobrir qual √© a melhor hora do dia para tuitar um artigo de peri√≥dico. M√©todos: De janeiro de 2020 a outubro de 2021, 112 artigos de uma revista m√©dica foram postados no Twitter tr√™s vezes cada, uma vez em cada idioma: portugu√™s, espanhol e ingl√™s. At√© dois artigos eram postados a cada semana, sendo que cada um dos tu√≠tes em uma semana era postado em uma hora diferente do dia: 06, 09, 12, 15, 18 ou 21:00. Impress√Ķes de tu√≠te e cliques em URL foram os dois desfechos dos modelos bayesianos de regress√£o binomial negativa multivariada multin√≠vel. Resultados: Nenhum par de horas do dia atingiu 95% de probabilidade a posteriori de incluir a melhor hora para tuitar um artigo de peri√≥dico, tanto para impress√Ķes como para cliques em URL. Os desfechos esperados, a rela√ß√£o entre os desvios padr√£o e a variabilidade explicada (R¬≤) todos corroboraram que a hora do dia √© de pouca import√Ęncia quando se tu√≠tam artigos de peri√≥dicos. Conclus√Ķes: Ao contr√°rio do conselho usual e da pesquisa pr√©-algoritmo, as equipes editoriais n√£o precisam se preocupar em otimizar a hora do dia em que divulgam seu conte√ļdo no Twitter.Introduction: Social media users are often advised to time their posts to increase readership and engagement. Our objective was to find out which is the best time to tweet a journal article. Methods: From January 2020 to October 2021, 112 articles from a medical journal were posted on Twitter three times each, once in each language: Portuguese, Spanish and English. Up to two articles were posted each week, with each of the week‚Äôs tweets being posted in a different hour of the day: 06, 09, 12, 15, 18 or 21:00. Tweet impressions and URL clicks were the two outcomes of the Bayesian multivariate multilevel negative binomial regression models. Results: No pair of times of the day achieved 95% posterior probability of including the best time to tweet a journal article, both for impressions and URL clicks. The expected outcomes, the ratio between standard deviations, and the explained variability (R¬≤) all corroborated that the time of the day is of little consequence when tweeting journal articles. Conclusions: Contrary to popular advice and pre-algorithm research, journal staff need not bother with optimizing the time of the day when they disseminate their content on Twitter

    RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease

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    We found an unanticipated recovery of several gliosis hallmarks and inflammasome key proteins upon neuronal RTP801 downregulation in the 5xFAD mice. Altogether our results suggest that RTP801 could be a potential future target for theranostic studies since it could be a biomarker of neuroinflammation and neurotoxicity severity of the disease and, at the same time, a promising therapeutic target in the treatment of AD

    Modellbasierte Simulation und Kalibrierung eines multimodalen Systems aus OCT und Optoakustik zur nichtinvasiven, präoperativen Dickenbestimmung von melanomverdächtigen Hautläsionen

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    In this dissertation, methods for the calibration of optical coherence tomography (OCT) systems and for the simulation of optoacoustic signals are presented. The key question here is whether a multimodal system consisting of OCT and optoacoustics is suitable for noninvasive, preoperative thickness determination of skin lesions suspected of melanoma and what conditions, if any, must be met for this purpose. Given the current state of the art, such a modality for melanoma diagnosis would be very enriching for dermatology. In addition to the definition of malignant melanoma, the most common diagnostic procedures in dermatology will be explained. The current approach to melanoma diagnostics shows that there is a lot of potential for improvement in order to be able to make diagnoses preoperatively in the future and to prevent unnecessary surgical interventions. The project in which this work was developed is briefly presented. It also discusses the physical principles needed to simulate and calibrate the multimodal system. The methods presented in chapters 6 and 7 for calibrating the OCT and for simulating the optoacoustic signals then build on these fundamentals. The general setup of OCT systems as well as of two specific OCT devices is explained. The methods then presented for geometric calibration and refractive index correction are essential for the thickness determination of structures in OCT images. In chapter 7 different methods are presented which are suitable for the simulation of optoacoustic signals. On the one hand, the solution of the direct problem, i.e. the creation of optoacoustic signals, is shown as well as the solution of the indirect problem, in which conclusions can be drawn about the initial pressure profile if optoacoustic signals are available. Furthermore, optoacoustic signals of simulated melanomas are generated and evaluated, which is also important for answering the key question. The results of this dissertation are discussed in detail at the end and an outlook is given on how the work on the multimodal system will continue.In der vorliegenden Dissertation werden Methoden zur Kalibrierung von Optischen Koh√§renztomographie (OCT)-Systemen und zur Simulation von Optoakustiksignalen pr√§sentiert. Die Kernfrage hierbei ist, ob ein multimodales System aus OCT und Optoakustik f√ľr eine nichtinvasive, pr√§operative Dickenbestimmung von melanomverd√§chtigen Hautl√§sionen geeignet ist und welche Bedingungen hierf√ľr gegebenenfalls erf√ľllt werden m√ľssen. Beim derzeitigen Stand der Technik w√§re solch eine Modalit√§t f√ľr die Melanomdiagnostik sehr bereichernd f ¬® ur die Dermatologie. Neben der Definition eines malignen Melanoms werden die gel√§ufigsten diagnostischen Verfahren in der Dermatologie erl√§utert. Das momentane Vorgehen bei der Melanomdiagnostik zeigt, dass hier sehr viel Potenzial f√ľr Verbesserungen ist, um zuk√ľnftig Diagnosen pr√§operativ vornehmen und unn√∂tige operative Eingriffe verhindern zu k√∂nnen. Es wird kurz das Projekt vorgestellt, in dem diese Arbeit entstanden ist. Au√üerdem werden die physikalischen Grundlagen er√∂rtert, die f√ľr die Simulation und Kalibrierung des multimodalen Systems ben√∂tigt werden. Auf diesen Grundlagen bauen dann die in Kapitel 6 und 7 vorgestellten Methoden zur Kalibrierung des OCT sowie zur Simulation der optoakustischen Signale auf. Es wird der allgemeine Aufbau von OCT-Systemen sowie von zwei speziellen OCT-Ger√§ten erkl√§rt. Die dann vorgestellten Methoden zur geometrischen Kalibrierung und zur Brechungsindexkorrektur sind unerl√§sslich f√ľr eine Dickenbestimmung von Strukturen in OCT-Bildern. In Kapitel 7 werden verschiedene Verfahren vorgestellt, die sich zur Simulation von optoakustischen Signalen eignen. Hier wird zum einen die L√∂sung des direkten Problems, also das Erzeugen von Optoakustiksignalen gezeigt sowie die L√∂sung des indirekten Problems, bei der R√ľckschluss auf das initiale Druckprofil geschlossen werden kann, wenn Optoakustiksignale vorliegen. Weiterhin werden Optoakustiksignale von simulierten Melanomen erzeugt und ausgewertet, was ebenfalls wichtig f√ľr die Beantwortung der Kernfrage ist. Die Ergebnisse dieser Dissertation werden zum Schluss ausf√ľhrlich er√∂rtert und es wird ein Ausblick darauf gegeben, wie die Arbeit am multimodalen System weitergeht

    Humanização Digital - um estudo de caso do grupo CRIATIVA

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    Nos √ļltimos anos foi percet√≠vel uma rutura nos sistemas de comunica√ß√£o, houve uma transforma√ß√£o digital e cultural, alterando a defini√ß√£o de comunidade. Nesse contexto √© vis√≠vel o paradoxo das tecnologias, benef√≠cios e impactos. Por√©m a desinforma√ß√£o se destaca, por ir al√©m da experi√™ncia do utilizador com os novos medias, pois afeta diretamente a consciencializa√ß√£o da sociedade. Estudos apontam que as tecnologias s√£o fruto da sociedade; ent√£o para estudar as tecnologias, √© preciso investigar as ci√™ncias humanas. √Č nesse contexto que esse estudo, faz emergir a denomina√ß√£o da Humaniza√ß√£o Digital. A Humaniza√ß√£o Digital, vem como uma rede de a√ß√Ķes para ressignificar a cibercultura a ponto de criar intera√ß√Ķes saud√°veis, mais inclus√£o social por meio da comunica√ß√£o e incentivar o crescimento de uma sociedade mais livre e consciente dos direitos humanos. Assim, transcender a intelig√™ncia coletiva, por meio da literacia, da colabora√ß√£o e da liberdade de tempo e espa√ßo. Com essa abordagem foi realizada uma investiga√ß√£o qualitativa, tendo como estudo de caso, o Grupo CRIATIVA, um hub tecnol√≥gico. Foi constru√≠do um laborat√≥rio vivo de intera√ß√Ķes cotidianas e entrevistas com stakeholders, resultando em uma √°rvore de cita√ß√Ķes, que demonstrou uma abordagem de a√ß√Ķes pr√°ticas, que elevam o ser humano √† primeira pessoa, inserindo a Humaniza√ß√£o Digital como responsabilidade social. Contudo, foi conclu√≠do que a Humaniza√ß√£o Digital deve ser cont√≠nua; processos auxiliares de boas pr√°ticas devem ser sempre implementados e constantes, para manter viva essas a√ß√Ķes; pois √© preciso estar sempre vigilante, afinal as tecnologias e o ser humano est√£o em constante evolu√ß√£o e converg√™ncia

    Essays on Risk Creation in the Banking Sector

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    This thesis consists of four essays exploring risk creation in the banking sector. The essays examine how conflicting interests can compromise the objectivity, judgment, and decision making of economic agents. Consequently, they may prioritize their personal or institutional interests over the best interests of others or the entire financial system. Chapter 2 delves into the conflict of interest that arises when a bank serves as an investor in the stock market. Chapter 3 revisits the discussion of the potential misalignment between sovereign incentives and the collective interests of the currency union, particularly in the bond market. Chapter 4 draws attention to a situation where regulations in the banking sector may be advantageous for a government in the sovereign bond market. Finally, Chapter 5 looks at the flip side of the coin, examining how banks may be susceptible to moral hazard concerns in their FX lending decisions, given that they do not fully bear the consequences of their actions

    The Structure and Function of the Retina in Multiple Sclerosis

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    Background: Multiple sclerosis (MS) is a complex heterogenous autoimmune inflammatory disease with a prolonged and variable time course. The visual system is frequently implicated, either as the presenting symptom, or, with advancement of the disease. This has been documented in the literature with changes in visual acuity (VA) that are accompanied by functional changes in the optic nerve, measured with the visual evoked potential (VEP) and possible retrograde degeneration involving the retinal ganglion cells in the retina, measured with the pattern reversal electroretinogram (PERG). However, inflammatory episodes may be clinical or subclinical in nature and may go unrecognised. Originating from the same embryological origins, the effect of inflammation in MS on the on the retina is less well known. The research hypothesis was that there is a measurable difference in the function of retinal cells in patients with newly diagnosed multiple sclerosis, suggestive of inflammatory retinopathy compared to healthy controls. The overall aim was to investigate any differences in the electrophysiological function of the visual pathway of patients newly diagnosed with MS compared to healthy controls. Methods: The visual system is explored with clinical (VA), electrophysiology (VEP and electroretinography (ERG ‚Äď pattern and flash) and structural (OCT) measures, in patients presenting with symptoms suggestive of MS to a specialist service. This prospective case control study investigates the visual pathway at the earliest stage of the disease to look for differences in structure and function between patients and healthy volunteers that might serve as a biomarker in the future. Results: There were a number of variables that were significantly different between the two groups, logistic regression analysis found that VA (p 0.038) and VEP P100 peak-time (p 0.014) from the right eye as significant. Dividing the participants by prolongation of the VEP P100 peak-time as defined in clinical practice, found a number of ERG amplitude variables as well as VA that were consistently different between the groups regardless of symptoms. Conclusion: The study confirms optic nerve involvement in MS with VEP and VA abnormalities consistent with the literature in this cohort. Additionally, VA and some ERG amplitude variables were significantly reduced in participants with MS, when grouped according to VEP P100 peak-time, suggesting inner and outer retinal changes. Further work would be required to confirm these findings. No OCT structural changes were found in any of the analysis that included the macula thickness, ganglion cell layer or retinal nerve fibre layer. Keywords: multiple sclerosis (MS), visual evoked potential (VEP), pattern electroretinogram (PERG), electroretinogram (ERG), optical coherence tomography (OCT

    Effects of heat stress on performance, physiological parameters, and blood profiles of early-fattening Hanwoo steers in climate chambers

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    Objective This study was conducted to assess effects of heat stress on growth performance, physiological parameters, and blood profiles of Hanwoo steers during early-fattening period in climate chambers. Methods Four Hanwoo steers (body weight, 454.3¬Ī10.9 kg; age, 14¬Ī0.1 month) were allocated into four levels of temperature-humidity index (THI) in a 4√ó4 Latin square design for 21 days (pre-adaptation, 7 d; heat stress, 7 d; post-adaptation, 7 d) per period. Experimental treatments were assigned according to THI chart based on National Institute Animal Science (NIAS, 2022): Comfort (25.5¬įC to 26.5¬įC, 60%; THI 73 to 75), Mild (28¬įC to 29¬įC, 60%; THI 77 to 79), Moderate (29.5¬įC to 30.5¬įC, 80%; THI 82 to 84), and Severe (31¬įC to 32¬įC, 80%; THI 85 to 86) in separate climatic controlled chambers. Results The dry matter intake (DMI) of the formula feed was lower in Severe compared to Mild and Comfort (p<0.05). The DMI of rice straw was the lowest in Severe and lower in Moderate than Comfort and Mild (p<0.05). Both average daily gain and feed conversion ratio of Severe and Moderate were lower than those of Mild and Comfort (p<0.05). Water intake was the highest in Severe and lower in Moderate compared with Comfort and Mild (p<0.05). Heart rate and rectal temperature increased as THI level increased (p<0.05). Glucose was the lowest in Severe and lower in Moderate compared to Comfort (p<0.05). On the contrary, non-esterified fatty acid was the highest in Severe and lower in Moderate compared with Comfort (p<0.05). Blood urea nitrogen of Moderate and Severe were higher than those of Comfort and Mild (p<0.05). Cortisol increased as THI increased (p<0.05). Conclusion This study demonstrated the negative effects of heat stress on the performance and physiological responses of Hanwoo steers during the early-fattening period. In addition, it is judged that the THI chart for Hanwoo steers of National Institute of Animal Science (2022) was properly calculated

    Information retrieval and machine learning methods for academic expert finding

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    In the context of academic expert finding, this paper investigates and compares the performance of information retrieval (IR) and machine learning (ML) methods, including deep learning, to approach the problem of identifying academic figures who are experts in different domains when a potential user requests their expertise. IR-based methods construct multifaceted textual profiles for each expert by clustering information from their scientific publications. Several methods fully tailored for this problem are presented in this paper. In contrast, ML-based methods treat expert finding as a classification task, training automatic text classifiers using publications authored by experts. By comparing these approaches, we contribute to a deeper understanding of academic-expert-finding techniques and their applicability in knowledge discovery. These methods are tested with two large datasets from the biomedical field: PMSC-UGR and CORD-19. The results show how IR techniques were, in general, more robust with both datasets and more suitable than the ML-based ones, with some exceptions showing good performance.Agencia Estatal de Investigación | Ref. PID2019-106758GB-C31Agencia Estatal de Investigación | Ref. PID2020-113230RB-C22FEDER/Junta de Andalucía | Ref. A-TIC-146-UGR2
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