Solid silica-based sulfonic acid: A remarkably efficient heterogeneous reusable catalyst for the one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones

A novel, efficient and one-pot method for preparation of 2H-indazolo [2,1-b] phthalazine-trione derivatives is reported using solid silica-based sulfonic acid as an effective heterogeneous catalyst under thermal and solvent-free conditions. This method has the advantages of high yields, a cleaner reaction, simple methodology, easy work-up and greener conditions. The catalyst is easily prepared, stable (up to 300 C), reusable and efficient under the reaction conditions. Keywords: Dimedone, 2H-indazolo[2,1-b]phthalazine-trione, indazolophthalazine, solid silica-based sulfonic aci

A Simple and Green Protocol for 2H-Indazolo[2,1-b]phthalazine-triones Using Grinding Method

A robust, facile, and solvent-free route for the three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones in the presence of a catalytic amount of p-toluene sulfonic acid utilizing grinding has been developed. Short reaction time, simple operation, and high yields are the advantages of this protocol

SYNTHESIS OF PHENYL 1H-INDAZOLO [1,2-b] PHTHALAZINE TRIONE DERIVATIVES WITH THEIR BIOLOGICAL EVALUATION

Heterocyclic compounds are the most global moieties in chemical compounds which exhibit wide spectrum of pharmacological activities. Multicomponent reactions are important tool in the hands of organic chemist’s,researcher. Since they offer improved atom economy for construction of complex molecules over the stepwise liner convergent synthesis. A simple, efficient and green protocol has been developed for the synthesis phenyl 1H-Indazolo [1,2-b] Phthalazine trione derivatives from a one pot four componant condensation of Phthalic anhydride, Hydrazine hydrate, Dimedone and different substituted aromatic aldehydes was refluxed independently in ethanol using Cesium Chloride as an efficient catalyst. Synthesized compounds were screened for their Antioxidant activity. These newly synthesized compounds were evaluated by their spectral analysis. Keywords: MCRs, Phthalic anhydride, Hydrazine hydrate, Dimedone, Aromatic aldehyd

Solvent-free synthesis of 2H-indazolo[2,1-b] phthalazine-triones promoted by cavitational phenomenon using iodine as catalyst

An environmentally benign, simple and efficient protocol for the synthesis of 2H-indazolo[2,1-b] phthalazine-triones by condensation of phthalhydrazide, aromatic aldehydes and dimedone under solvent-free ultrasound assisted conditions employing a safe, readily available iodine as catalyst has been described. This process is a valuable addition as it devoids the use of any solvent and takes place in short duration of time giving good yield of the products

A magnetically-separable H3PW12O40@Fe3O4/EN-MIL-101 catalyst for the one-pot solventless synthesis of 2H-indazolo[2,1-b] phthalazine-triones

A magnetic inorganic-organic catalyst, PTA@Fe3O4/EN-MIL-101 (EN = ethylenediamine, PTA = phosphotungstic acid) was fabricated and characterized by XRD, HRTEM, FESEM, UV–vis, TGA-DTA, FT-IR, XPS and porosimetry. PTA retained the parent Keggin structure upon dispersion throughout the amine-functionalized chromium terephthalate metal-organic framework, over which magnetic Fe3O4 nanoparticles were previously introduced. The resulting composite heterogeneous solid acid was an active catalyst for the one-pot synthesis of diverse 2H-indazolo[2,1-b] phthalazine-triones in good → excellent yields under mild, solventless condition, and offers facile separation and excellent recyclability

A convenient catalytic synthesis of 2H-indazolo[2,1-b]phthalazine-triones on reusable silica supported Preyssler heteropolyacid

Efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives was achieved by one-pot threecomponent condensation reaction of phthalhydrazide, dimedone, and aromatic aldehydes under solvent-free conditions. Good to excellent yields were obtained at short reaction times on the reusable silica supported Preyssler heteropolyacid catalyst

Montmorillonite K-10 Supported 11-molybdo-1-vanadophosphoric Acid (H4PMo11V1O40/K-10) Catalysts for Environmentally Benign Synthesis of 2H-indazolo[2,1-b]phthalazine-triones Under Solvent-free Condition

A series of 11-molybdo-1-vanadophosphoric acid supported on montmorillonite K-10 catalysts were prepared and characterized by FT-IR spectroscopy, thermal analysis, XRD, BET and SEM analysis techniques. Characterization data reveals the chemical immobilization of H4PMo11V1O40 catalyst on the montmorillonite K-10 support. The catalytic performance of synthesized catalysts was investigated for the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives by one-pot three-component reaction of phthalhydrazide, dimedone and aromatic aldehydes under solvent-free conditions. Among different catalysts, 20% H4PMo11V1O40 supported on to montmorillonite K-10 showed the highest catalytic activity. Effect of reaction parameters such as catalyst loading, temperature and the nature of substituents on the aromatic ring of aldehydes were also evaluated. The protocol developed using H4PMo11V1O40/K-10 has several distinct advantages such as operational simplicity, short reaction time, high yield, reusable catalyst and preclusion of toxic solvent. DOI: http://dx.doi.org/10.17807/orbital.v9i4.87

Fitalazin sübstitüe üre (tiyoüre) ve β-laktam türevlerinin sentezi

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Bu araştırma kapsamında; başlangıç maddesi olarak kullanılan 2H-indazol[2,1- b]fitalazin-trion türevi DMF içerisinde TFA varlığında 4-nitro benzaldehit, dimedon ve fitalhidrazit ile hazırlandı ve yapıya ait nitro grubu amin yapısına SnCl2.4H2O ile indirgendirildi. Daha sonra elde edilen indirgenmiş ürün çeşitli izosiyanat ve tiyoizosiyanatlar ile reaksiyona sokularak yeni aril-aril, aril-alkil üre ve tiyoüre türevlerinin sentezi gerçekleştirildi. Ayrıca indirgenmiş ürün bazı aromatik aldehitler ile reaksiyona sokularak imin bileşiklerinin sentezi gerçekleştirildi ve bu sentez üzerinden de yeni β-laktam türevlerinin oluşum reaksiyonları incelendi. Sentezlenen bileşikleri kromatrofik yöntemlerle saflaştırıldıktan sonra yapıları 1HNMR, 13C-NMR, IR ve Kütle spektrometreleri ile aydınlatıldı. Tez kapsamında 20 üre, 10 tiyoüre, 5 imin ve 10 beta-laktam olmak üzere toplamda literatürde bulunmayan 45 yeni maddenin sentezi gerçekleştirildi.Scope of this research, 2H-indazolo[2,1-b]phthalazine-trione derivative was prepared with 4-nitrobenzaldehyde, dimedone and phthalhydrazide in the presence of TFA in DMF and nitro group was reduced to amine derivative with SnCl2.2H2O. Then, the reduced product is reacted with various isocyanate and tiyoizosiyanatlar synthesis of new aryl-aryl, aryl-alkyl urea and thiourea derivatives were performed. In addition, the reduction compount reacted with some aromatic aldehydes. imine compounts synthesis was performed and this synthesis via reactions in the formation of new β-lactam derivatives were investigated. After purification chromatographic methods the structures of the synthesized compounds were determined by 1 H-NMR, 13C-NMR, IR and Mass spectrometers. The scope of the thesis is not in the literature were synthesised 45 new compounds that are 10 urea, 20 thiourea, 5 imine and 10 beta-lactam compounds