37 research outputs found

    Consumer Price of Selected Goods and Services for Clothing Groups in 66 Cities in Indonesia 2012

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    Data presented in this publication is monthly consumer price of various goods in group, based on monthly consumer price survey in 66 cities ( 33 provincial capitals and 33 cities ) during 2012

    Consumer Price of Selected Goods and Services for Clothing Groups in 66 Cities in Indonesia 2013

    Full text link
    Data presented in this publication is monthly consumer price of various goods in group, based on monthly consumer price survey in 66 cities (33 provincial capitals and 33 cities) during 2013

    Adaptasi dan Perluasan Dewey Decimal Classification (DDC) untuk Notasi (Subjek) Indonesia

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    Tulisan ini memaparkan cara-cara menentukan notasi DDC secara spesifik agar proses temu balik dokumen menjadi lebih efektif dan efisien. selama ini sebagian dari kita mungkin beranggapan bahwa semakin panjang notasi maka akan semakin spesifik pula subjek suatu dokumen. Padahal ada cara khusus yang memungkinkan bahwa notasi yang lebih pendek pun dapat menunjukkan subjek yang lebih spesifik pula. Hal ini memang diberikan pilihan oleh DDC kepada pengkatalog untuk memilih selama dengan catatan memegang prinsip konsisten dalam penggunaannya. Paparan singkat diharapkan dapat membantu para pengkatalog terutama Classifier dalam menentukan notasi yang lebih singkat namun menunjukkkan subjek yang lebih spesifik. Perluasan notasi di sini dikhususkan untuk wilayah Indonesia yang meliputi perluasan wilayah, bahasa dan sastra, bangsa/ras, perundang-undangan, administrasi dan pemerintahan serta subjek-subjek spesifik lainnya

    Capital-labor complementarity for different educational groups in U.S. manufacturing

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    Employment and productivity of the work: a descriptive analysis for the galician and spanish industry

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    Texto dispoñible en galego e españolNeste traballo estúdiase o emprego da industria galega mediante a Encuesta Industrial de Empresas, desde dúas vertentes: por unha parte, desde unha perspectiva comparada coa industria española e, por outra, desde unha perspectiva de evolución temporal durante o período 1993 a 1999. Preséntase evidencia do crecemento experimentado no emprego durante este período expansivo, aínda que se detectan algunhas diferencias entre a industria galega e a española. Mentres que na primeira foron as grandes empresas as que xeraron máis emprego, na segunda foron as empresas de menor tamaño. Tamén se mostra que os custos laborais e a productividade do traballo (medida en termos de valor engadido por traballador ou por hora) están correlacionados de maneira positiva co tamaño da empresa e co nivel tecnolóxico do sector no que operanThis paper analyses the growth of employment of Galician industry between 1993 and 1999 using data from the Encuesta Industrial de Empresas. This analysis has been done from two points of view: from a comparative perspective of the Spanish industry and from a temporary perspective during the period. The results show that there are differences between the Galician and Spanish industry in terms of the employment growth experimented during the period. While the increase of employment in Galicia is mainly due to big companies, the small firms have been the main source of employment growth in Spain. We also show that the labor costs and the work productivity (either in terms of value added by worker or by hour) are positively correlated with the size of the company and the technological level of the sector in which they operateEn este trabajo se estudia el empleo de la industria gallega mediante la Encuesta Industrial de Empresas, desde dos vertientes: por una parte, desde una perspectiva comparada con la industria española y, por otra, desde una perspectiva de evolución temporal durante el período 1993 a 1999. Se presenta evidencia del crecimiento experimentado en el empleo durante este período expansivo, aunque se detectan algunas diferencias entre la industria gallega y la española. Mientras que en la primera han sido las grandes empresas las que han generado más empleo, en la segunda han sido las empresas de menor tamaño. También se muestra que los costes laborales y la productividad del trabajo (medida en términos de valor añadido por trabajador o por hora) están correlacionados de manera positiva con el tamaño de la empresa y con el nivel tecnológico del sector en el que operanS

    Synthesis and Biological Evaluation of Small Molecular Drug Candidates for the Treatment of Her2 Overexpressed Breast Cancer

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    In the US breast cancer is the most common cancer after skin cancer. Currently in the US the average risk of a woman to develop breast cancer in her life is roughly 12%. About 25-30% of breast cancer patients have HER2 overexpressed tumor, and the growth of tumor cell is depend on HER2 pathway. It has been well-documented that patients with over-expressed HER2 are associated with increased disease recurrence, worse prognosis and lower survival. Currently there are two type of HER2 targeting drug. The first group is HER2 monoclonal antibody drugs such as trastuzumab approved by FDA in 1998; the second type is intracellular tyrosine kinase inhibitors such as lapatinib approved by FDA in 2007. Presently trastuzumab is one of the most efficient in clinic for HER2 over-expressed breast cancer patients, however many patients didn’t gain benefit due to the de novo or acquire resistance. The resistance of trastuzumab involves multiple cellular pathway, research indicates that HSP27 participate in the development of resistance. There are studies indicate that HER2 is one of the client proteins of HSP27. HER2 would be downregulated via inhibition of HSP27. Previously, a lead compound JCC76 which generated from COX-2 inhibitor Nimesulide was found to target HSP27. Herein, 23 analogs of JCC76 were synthesized. Cell viability assay was used for screen the analogs that selectively inhibit HER2 overexpressed cell proliferation. Western-blot and chaperone assay were used to investigate the anti-proliferate cellular mechanism. The selected compounds, 16 and 17, inhibited the protective function of small chaperone. In the HER2 downregulation experiment, the results indicate a dose-dependent downregulation of HER2 for both compounds. In the second study we try to improve the druggable characteristics of the compounds by reducing the compound size and molecular weight. Totally 60 compounds were synthesized and screen for cell growth inhibitory ability against variance cell line, 5 compounds with potent proliferate inhibitory activity were identified. The SAR study indicates several compounds with 3-trifluoromethylbenzamide groups showed potent and selective inhibition of HER2 overexpressed breast cancer cells
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