Vibration-Based structural health monitoring using piezoelectric transducers and parametric t-SNE

In this paper, we evaluate the performance of the so-called parametric t-distributed stochastic neighbor embedding (P-t-SNE), comparing it to the performance of the t-SNE, the non-parametric version. The methodology used in this study is introduced for the detection and classification of structural changes in the field of structural health monitoring. This method is based on the combination of principal component analysis (PCA) and P-t-SNE, and it is applied to an experimental case study of an aluminum plate with four piezoelectric transducers. The basic steps of the detection and classification process are: (i) the raw data are scaled using mean-centered group scaling and then PCA is applied to reduce its dimensionality; (ii) P-t-SNE is applied to represent the scaled and reduced data as 2-dimensional points, defining a cluster for each structural state; and (iii) the current structure to be diagnosed is associated with a cluster employing two strategies: (a) majority voting; and (b) the sum of the inverse distances. The results in the frequency domain manifest the strong performance of P-t-SNE, which is comparable to the performance of t-SNE but outperforms t-SNE in terms of computational cost and runtime. When the method is based on P-t-SNE, the overall accuracy fluctuates between 99.5% and 99.75%.Peer ReviewedPostprint (published version

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study.

Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans. Intestinal microbes are important contributors to variability; however, such gut microbe-drug interactions and the clinical significance of these interactions are still being elucidated. Traditional PKs can be complemented by untargeted mass spectrometry coupled with molecular networking to study the intricacies of drug metabolism. To show the utility of molecular networking on metabolism we investigated the impact of a 7-day course of cefprozil on cytochrome P450 (CYP) activity using a modified Cooperstown cocktail and assessed plasma, urine, and fecal data by targeted and untargeted metabolomics and molecular networking in healthy volunteers. This prospective study revealed that cefprozil decreased the activities of CYP1A2, CYP2C19, and CYP3A, decreased alpha diversity and increased interindividual microbiome variability. We further demonstrate a relationship between the loss of microbiome alpha diversity caused by cefprozil and increased drug and metabolite formation in fecal samples. Untargeted metabolomics/molecular networking revealed several omeprazole metabolites that we hypothesize may be metabolized by both CYP2C19 and bacteria from the gut microbiome. Our observations are consistent with the hypothesis that factors that perturb the gut microbiome, such as antibiotics, alter drug metabolism and ultimately drug efficacy and toxicity but that these effects are most strongly revealed on a per individual basis

Damage identification in structural health monitoring: a brief review from its implementation to the Use of data-driven applications

The damage identification process provides relevant information about the current state of a structure under inspection, and it can be approached from two different points of view. The first approach uses data-driven algorithms, which are usually associated with the collection of data using sensors. Data are subsequently processed and analyzed. The second approach uses models to analyze information about the structure. In the latter case, the overall performance of the approach is associated with the accuracy of the model and the information that is used to define it. Although both approaches are widely used, data-driven algorithms are preferred in most cases because they afford the ability to analyze data acquired from sensors and to provide a real-time solution for decision making; however, these approaches involve high-performance processors due to the high computational cost. As a contribution to the researchers working with data-driven algorithms and applications, this work presents a brief review of data-driven algorithms for damage identification in structural health-monitoring applications. This review covers damage detection, localization, classification, extension, and prognosis, as well as the development of smart structures. The literature is systematically reviewed according to the natural steps of a structural health-monitoring system. This review also includes information on the types of sensors used as well as on the development of data-driven algorithms for damage identification.Peer ReviewedPostprint (published version

Efficient Two-Step Approach for Automatic Number Plate Detection

intelligent transportation systems are rapidly growing mainly due to active development of novel hardware and software solutions. In the paper a problem of automatical number plate detection is considered. An efficient two-step approach based on plate candidates extraction with further classification by neural network is proposed. Stroke width transform and contours detection techniques are utilized for the image preprocessing and extraction of regions of interest. Different local feature sets are used for the final number plate extraction step. Efficiency of the developed method is tested with real datasets