1,054,866 research outputs found

    Funding Era Free Speech Theory: Applying Traditional Speech Protection to the Regulation of Anonymous Cyberspace

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    Abstract Background Blunt trauma is the most frequent mechanism of injury in multiple trauma, commonly resulting from road traffic collisions or falls. Two of the most frequent injuries in patients with multiple trauma are chest trauma and extremity fracture. Several trauma mouse models combine chest trauma and head injury, but no trauma mouse model to date includes the combination of long bone fractures and chest trauma. Outcome is essentially determined by the combination of these injuries. In this study, we attempted to establish a reproducible novel multiple trauma model in mice that combines blunt trauma, major injuries and simple practicability. Methods Ninety-six male C57BL/6 N mice (n = 8/group) were subjected to trauma for isolated femur fracture and a combination of femur fracture and chest injury. Serum samples of mice were obtained by heart puncture at defined time points of 0 h (hour), 6 h, 12 h, 24 h, 3 d (days), and 7 d. Results A tendency toward reduced weight and temperature was observed at 24 h after chest trauma and femur fracture. Blood analyses revealed a decrease in hemoglobin during the first 24 h after trauma. Some animals were killed by heart puncture immediately after chest contusion; these animals showed the most severe lung contusion and hemorrhage. The extent of structural lung injury varied in different mice but was evident in all animals. Representative H&E-stained (Haematoxylin and Eosin-stained) paraffin lung sections of mice with multiple trauma revealed hemorrhage and an inflammatory immune response. Plasma samples of mice with chest trauma and femur fracture showed an up-regulation of IL-1β (Interleukin-1β), IL-6, IL-10, IL-12p70 and TNF-α (Tumor necrosis factor- α) compared with the control group. Mice with femur fracture and chest trauma showed a significant up-regulation of IL-6 compared to group with isolated femur fracture. Conclusions The multiple trauma mouse model comprising chest trauma and femur fracture enables many analogies to clinical cases of multiple trauma in humans and demonstrates associated characteristic clinical and pathophysiological changes. This model is easy to perform, is economical and can be used for further research examining specific immunological questions

    A History of Trauma is Associated with Aggression, Depression, Non-Suicidal Self-Injury Behavior, and Suicide Ideation in First-Episode Psychosis.

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    The association between trauma and psychosis outcomes is well-established, and yet the impact of trauma on comorbid clinical symptoms-such as aggression, non-suicidal self-injury behavior (NSSIB), suicide ideation, and suicide behavior-for those with psychosis is unclear. To effectively treat those with first-episode psychosis (FEP) and a history of trauma, we need to understand the impact of trauma on their whole presentation. FEP participants were recruited from an Early Psychosis Program (N = 187, ages 12-35, 72.2% male). Clinicians gathered history of trauma, aggression, and suicide data, and rated current symptom severity and functioning. Data was coded using clinician rated measures, self-report measures, and retrospective clinical chart review. Regression analyses examined whether trauma was associated with a history of aggression, suicidal ideation, suicide behavior, NSSIB, symptoms, and functioning. Trauma was associated with aggression, aggression severity and type of aggression (aggression towards others). Trauma was also associated with depression severity, suicide ideation, most severe suicide ideation, and NSSIB. Trauma was not associated with suicide behavior, severity of suicide behavior or psychosocial functioning. Integrating trauma treatment into FEP care could reduce rates of depression, aggression, suicide ideation, and NSSIB for those with a history of trauma. To reduce suicide attempt occurrence and improve functioning, more research is needed

    Policy Essay: Fostering the acceptance and inclusion of LGBTQ youth in the child welfare system: Considerations for advancing trauma informed responses for LGBTQ youth in care

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    LGBTQ youth are vulnerable to nearly all forms of childhood maltreatment and trauma and are disproportionately overrepresented in the child welfare system. Many LGBTQ youth in the child welfare system encounter a number of obstacles related to discrimination, rejection, placement instability, and further maltreatment. Despite recent insights and advances in the field of trauma informed care the trauma experiences of LGBTQ youth have largely gone unaddressed in major works and frameworks related to trauma informed care. The following article explores the unique trauma and maltreatment experiences of LGBTQ youth and provides considerations for enhancing and improving practice with LGBTQ youth through the implementation of recent insights in the field of trauma informed care

    Alaska Trauma Registry: Trauma Admissions Involving Firearms, 2009-2014

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    This fact sheet presents data from the Alaska Trauma Registry (ATR) on characteristics of trauma admissions for the period 2009–2014 for injuries for which a firearm was the main mechanism of injury. The Alaska Trauma Registry (ATR) is an active surveillance system that collects data pertaining to hospitalizations of the most seriously injured patients in Alaska.Bureau of Justice Statistics, U.S. Department of JusticeTrauma admissions / Firearms-related admissions / Firearms-related trauma admissions by gender / Firearms-related trauma admissions by age / Injury mechanism / Summary / Note

    Trauma-Informed Care in a School Setting: Occupational Therapy Interventions to Promote Emotional Regulation

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    PICO Question What trauma-informed occupational therapy interventions improve emotional regulation and participation in school-based tasks for students? Objectives Define trauma and note its prevalence among school-aged children Describe principles of Trauma-Informed Care and its importance in a school setting. Describe current research to determine best practice using a Trauma-Informed Care (TIC) approach in schools for OT practitioner

    Eye movement desensitisation and reprocessing for offence-related trauma in a mentally disordered sexual offender

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    Research demonstrates a high incidence of offence-related trauma in mentally disordered offenders convicted of violent and sexual offences. The adaptive information processing (AIP) model offers a theoretical framework for understanding the hypothesised relationship between offence-related trauma and reoffending. Evidence suggests that for a sub-population of offenders presenting with offence-related trauma: (1) therapy may retraumatise them, and (2) unresolved trauma severely blocks the positive benefits of talking therapies. Thus, it is postulated that traumatised violent and sexual offenders may be released into the community when they are still at risk of reoffending. A single case study is presented, which describes the application of eye movement desensitisation and reprocessing (EMDR) for a sexual offender presenting with offence-related trauma, whose offences occurred in the context of serious mental disorder. The identification of offence-related trauma and subsequent resolution of trauma symptomatology are discussed in regard to effective offender rehabilitation. Furthermore, the idiosyncratic nature of offence-related trauma and the application of the standard EMDR protocol for a single traumatic event are considered

    Mothering, substance use disorders and intergenerational trauma transmission : an attachment-based perspective

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    Background: A growing body of research underlines that interpersonal trauma in childhood leads to heightened susceptibility for substance use disorders (SUDs) in later life. Little research has been conducted on parenting experiences of mothers in recovery from substance use, taking into account their own upbringing as a child and the potential aftermath of interpersonal childhood trauma. Methods: Through in-depth qualitative interviews, 23 mothers with SUDs reflected on parenting experiences and parent-child bonding, related to both their children and parents. Interviews were transcribed verbatim and data were analyzed adopting thematic analysis. Results: Throughout the narratives, consequences of trauma on mothers' sense of self and its subsequent impact on parenting arose as salient themes. Five latent mechanisms of intergenerational trauma transmission were identified: 1) early interpersonal childhood trauma experiences in mothers; 2) trauma as a precursor of substance use; 3) substance use as a (self-fooling) enabler of parental functioning; 4) continued substance use impacting parental functioning; and 5) dysfunctional parental functioning and its relational impact upon offspring. Discussion: Findings suggest disruptive attachment can increase the vulnerability for SUDs on the one hand, but can be an expression of underlying trauma on the other, hence serving as a covert mechanism by which trauma can be transmitted across generations. Results indicate the need for preventive, attachment-based and trauma-sensitive interventions targeted at disruptive intergenerational patterns

    Alaska Trauma Registry: Trauma Admissions Involving Alcohol or Illegal Drugs, 2014

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    This fact sheet presents data from the Alaska Trauma Registry (ATR) on numbers of trauma admissions, patient demographics, and the presence of alcohol or illegal drugs in trauma admissions in 2014. The Alaska Trauma Registry (ATR) is an active surveillance system that collects data pertaining to hospitalizations of the most seriously injured patients in Alaska.Bureau of Justice Statistics, U.S. Department of JusticeTrauma admissions / Alcohol-related admissions / Illegal drug-related admissions / Note

    Abdominal trauma in dogs 2. management

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    Trauma represents a big challenge for emergency doctors both in human and veterinary medicine. There have been great advancements in trauma medicine in people and these often provide an inspiration for veterinary surgeons. However, the vast differences in the facilities and finances available in human and veterinary medicine make the approach to trauma in both fields quite different. This article, the second in a two-part series, describes how to manage canine trauma patients. The first part focused on the initial investigation of canine abdominal trauma. Although this article will mention guidelines in people, these should not be automatically applied to dogs, especially when more relevant evidence for this species exists
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