Mutational signatures in colon cancer.

ObjectiveRecently, many tumor sequencing studies have inferred and reported on mutational signatures, short nucleotide patterns at which particular somatic base substitutions appear more often. A number of signatures reflect biological processes in the patient and factors associated with cancer risk. Our goal is to infer mutational signatures appearing in colon cancer, a cancer for which environmental risk factors vary by cancer subtype, and compare the signatures to those in adult stem cells from normal colon. We also compare the mutational signatures to others in the literature.ResultsWe apply a probabilistic mutation signature model to somatic mutations previously reported for six adult normal colon stem cells and 431 colon adenocarcinomas. We infer six mutational signatures in colon cancer, four being specific to tumors with hypermutation. Just two signatures explained the majority of mutations in the small number of normal aging colon samples. All six signatures are independently identified in a series of 295 Chinese colorectal cancers

4 Signatures

This study is accomplished to assist the readers of the graphic novel project that is created to understand more about the elements in the graphic novel 4 Signatures. The purpose of this graphic novel is to educate people about the psychological aspects, what cause it and the results, and to support those who have similar psychological problem.Using the theory of Revenge and Child Abuse, this graphic novel will show the story and the attitudes of the main character cause by psychological problems. The awful result whether it is emotional, verbal, or physical done toward other people by the character helps the readers to understand more of what to do to someone with similar psychological problem and to avoid such psychological problems

Numerical study on signatures of atmospheric convective cells in radar images of the ocean

Current and wind variations at the ocean surface can give rise to a modulation of the sea surface roughness and thus become visible in radar images. The discrimination between radar signatures of oceanic and atmospheric phenomena can be quite difficult, since signatures of different origin can have very similar shapes and magnitudes and are often superimposed upon each other. In this work we employ a numerical radar imaging model for an investigation of typical properties of radar signatures of atmospheric convective cells and of theoretical differences between such atmospherically induced radar signatures and those of oceanic phenomena. We show that main characteristics of observed multifrequency/multipolarization radar signatures of atmospheric convective cells over the Gulf Stream are reproduced quite well by the proposed model. This encourages us to vary wind and radar parameters systematically in order to get a general overview of the dependency of atmospherically induced radar signatures on these parameters. Finally, we compare typical characteristics of radar signatures of atmospheric and oceanic phenomena, and we present simulated radar images of a scenario of superimposed atmospheric convective cells and oceanic internal waves. We show that the proposed model supports the experimental finding that radar signatures of oceanic phenomena are stronger at horizontal (HH) than at vertical (VV) polarization, while atmospherically induced radar signatures are better visible at VV polarization

Multilepton Signatures of the Higgs Boson through its Production in Association with a Top-quark Pair

We consider the possible production of the Higgs Boson in association with a top-quark pair and its subsequent decay into a tau-lepton pair or a W-boson pair. This process can give rise to many signatures of the Higgs boson. These signatures can have electrons, muons, tau jets, bottom jets and/or light flavour jets. We analyze the viability of some of these signatures. We will look at those signatures where the background is minimal. In particular, we explore the viability of the signatures "isolated 4 electron/muon" and "isolated 3 electron/muon + a jet" The jet can be due to a light flavour quark/gluon, a bottom quark, or a tau lepton. Of all these signatures, we find that "isolated 3 electron/muon + a tau jet", with an extra bottom jet, can be an excellent signature of this mode of the Higgs boson production. We show that this signature may be visible within a year, once the Large Hadron Collider (LHC) restarts. Some of the other signatures would also be observable after the LHC accumulates sufficient luminosity.Comment: 11 pages, 1 Figur