516,313 research outputs found

    Side Effects of Google

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    Throughout history, humans and technology have developed simultaneously. The internet is one of the most modern examples of this phenomenon and researchers have noticed that as the internet becomes increasingly available, humans rely on it more. As a result, people seem to retain less information, and what they do remember is often false or misleading. This article examines the impact the internet has had on memory, education, and healthcare

    Checkpoint inhibitors: What gastroenterologists need to know.

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    Checkpoint inhibitors are increasingly being used in clinical practice. They can cause various gastrointestinal, hepatic and pancreatic side effects. As these side effects can be serious, appropriate management is essential. The different checkpoint inhibitors with their mechanisms of action and indications, as well as evaluation and management of gastrointestinal, hepatic and pancreatic side effects, are discussed in this article

    Mining Frequency of Drug Side Effects Over a Large Twitter Dataset Using Apache Spark

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    Despite clinical trials by pharmaceutical companies as well as current FDA reporting systems, there are still drug side effects that have not been caught. To find a larger sample of reports, a possible way is to mine online social media. With its current widespread use, social media such as Twitter has given rise to massive amounts of data, which can be used as reports for drug side effects. To process these large datasets, Apache Spark has become popular for fast, distributed batch processing. In this work, we have improved on previous pipelines in sentimental analysis-based mining, processing, and extracting tweets with drug-caused side effects. We have also added a new ensemble classifier using a combination of sentiment analysis features to increase the accuracy of identifying drug-caused side effects. In addition, the frequency count for the side effects is also provided. Furthermore, we have also implemented the same pipeline in Apache Spark to improve the speed of processing of tweets by 2.5 times, as well as to support the process of large tweet datasets. As the frequency count of drug side effects opens a wide door for further analysis, we present a preliminary study on this issue, including the side effects of simultaneously using two drugs, and the potential danger of using less-common combination of drugs. We believe the pipeline design and the results present in this work would have great implication on studying drug side effects and on big data analysis in general

    Patient-Reported Side Effects of Intradetrusor Botulinum Toxin Type A for Idiopathic Overactive Bladder Syndrome

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    Objective: The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB). Patients and Methods: Botulinum toxin A injection was performed in 56 patients with idiopathic OAB. Patients were followed up for 6 months concerning side effects and patients' satisfaction. Results: Different types of side effects were assessed such as dry mouth (19.6%), arm weakness (8.9%), eyelid weakness (8.9%), leg weakness (7.1%), torso weakness (5.4%), impaired vision (5.4%) and dysphagia (5.4%). In all cases, symptoms were mild and transient. Urological complications such as gross hematuria (17.9%), acute urinary retention (8.9%) and acute urinary tract infection (7.1%) were noticed. In all cases, acute urinary retention was transient and treated with temporary intermittent self-catheterization. There was no statistically significant correlation between dosage and observed side effects. Patients' satisfaction rate was high (71.4%). Conclusion: Intradetrusor injection of botulinum toxin was associated with a high rate of neurourological side effects. In general, side effects were transient, mild and did not require special treatment. Copyright (C) 2010 S. Karger AG, Base

    Side Effects and the Structure of Deliberation

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    There is a puzzle about the very possibility of foreseen but unintended side effects, and solving this puzzle requires us to revise our basic picture of the structure of practical deliberation. The puzzle is that, while it seems that we can rationally foresee, but not intend, bringing about foreseen side effects, it also seems that we rationally must decide to bring about foreseen side effects and that we intend to do whatever we decide to do. I propose solving this puzzle by rejecting the idea that we intend to do whatever we decide to do. My solution involves taking account of the underappreciated role that qualified intentions play in deliberation. I also argue that this solution fares better than those that instead reject the idea that we rationally must decide to bring about foreseen side effects, for these solutions are committed to rejecting the even more compelling idea that decisions rationally serve as the conclusions of practical deliberation
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