Level of Serum Uric Acid in Pre-eclamptic and Normal Pregnant Women

Objective: The objective of study was to find out serum uric acid level in normal andpreeclamptic pregnant women of third trimester visiting outpatient department of obstetrics and gynecology of Bahawal Victoria Hospital, Bahawalpur. Methodology: It was a cross sectional descriptive study conducted form July 2018 to June 2019. All primigravida women of age 18-35 years in third trimester of singleton pregnancy attending in Obstetrics and Gynecology Outpatient Department of Bahawal Victoria Hospital in study duration were included in the study. Statistical analysis was performed by using SPSS version 14. Chi-square test was performed to find the statistical difference regarding uric acid distribution between groups and ‘p' value <0.05 was considered as a lowest level of significance. Results: Out of total 1212 women 84.6% were normal and 15.4% had preeclampsia. In our study out of 187 preeclamptic women, 63.6% had raised serum uric acid level and out of 268 normal pregnant women uric acid level was raised in only 39.5%. Results were found statistically significant. Conclusion: Results of our study suggest that serum uric acid level in pregnant women can be used as a useful and inexpensive marker in prediction of preeclampsia and preventive measures can be taken accordingly

Relationship between platelet count and platelet width distribution and serum uric acid 1 concentrations in patients with untreated essential hypertension

Hematological parameters have emerged as independent determinants of high serum concentrations of uric-acid and predictive-factors in the evaluation of the total cardiovascular-risk in patients with essential-hypertensive. Here we have investigated the possible relationships between hematological-factors and serum uric-acid levels in hypertensive-patients recruited as part of Mashhad-Stroke and Heart-Atherosclerotic-Disorders cohort study. Two-thousand three-hundred and thirty four hypertensive individuals were recruited from this cohort and these were divided into two groups; those with either high or low serum uric acid concentrations. Demographic, biochemical and hematological characteristics of population were evaluated in all the subjects. Logistic-regression-analysis was performed to determine the association of hematological-parameters with hypertension. Of the 2334 hypertensive-subjects, 290 cases had low uric-acid, and 2044 had high serum uric acid concentrations. Compared with the low uric acid group, the patients with high serum uric acid, had higher values for several hematological parameters, whilst platelet counts (PLT) were lower. Multiple linear regression analysis showed that PLT and serum hs-CRP were correlated with serum uric acid level. Stepwise multiple logistic regression model confirmed that PDW and gender were independent determinant of a high serum uric acid. PDW and PLT appear to be independently associated with serum uric acid level in patients with hypertension

Uric acid and hypertension: Does uric acid lick the joints and bites the heart?

Background: Uric acid a metabolic end product of purine degradation is implicated in gout as aetiology. Its increased levels have also been associated with hypertension, cardiovascular morbidity and mortality. Few studies have been conducted, especially in India to elucidate association of uric acid with prehypertension. Aims: This study intends to assess the association of serum uric acid levels with blood pressure in normotensive, prehypertensive and hypertensive population. It also intends to check whether there is an incremental rise of serum uric acid with increasing blood pressure. Material and methods: Two hundred outpatients who met inclusion and exclusion criteria and consented formed study population. Blood pressure of each participant was measured followed by venipuncture to collect venous blood for measurement of serum uric acid. Participants were categorised into 4 groups as Normal, Prehypertension, Hypertension –Stage 1, Hypertension Stage -2 as per Joint National Committee 7 classification. Data was analysed to know levels of serum uric acid among the four categories and to verify association of uric acid with blood pressure. Results and Conclusions: Stepwise increase in serum uric acid levels was observed along with increasing blood pressure. Strong positive linear correlation was observed between serum uric acid levels and mean blood pressure (Pearson’s correlation coefficient r = 0.74; p< 0.0001). Uric acid was associated (r = 0.442) with blood pressure in prehypertension population. Serum uric acid levels are associated with prehypertension and hypertension and are independent and strong predictors of cardiovascular mortality

Study on Serum Uric Acid levels in Essential Hypertension

BACKGROUND AND OBJECTIVES: Hypertension is one of the leading causes of death and disability among adults all over the world. It remains the major risk factor for coronary, cerebral and peripheral vascular disease. Essential hypertension comprises more than 90% of hypertension. Hypertension is an emerging health problem in India. Raised serum uric acid has been reported to be associated with an increased risk of coronary heart disease and is commonly encountered with essential hypertension, even untreated hypertension, and type 2 diabetes, which are in turn associated with coronary heart disease. In our study, an attempt has been made to study the prevalence of elevated uricacid levels in essential hypertension and the correlation between elevated uric acid levels and hypertensive target organ damage. METHODS AND RESULTS: In this Hospital based study for the CORRELATION OF SERUM URIC ACID LEVELS IN ESSENTIAL HYPERTENSION 300 patients who attended the out-patient and in-patient at the Institute of Internal Medicine, Madras Medical College, Chennai were evaluated for Serum Uric Acid levels of which 150 were cases and 100 Were controls. The method of Caraway was used for the estimation of creatinine based on Jaffe’s reaction. INTERPRETATION: The mean age for cases in this study is 52.74 years. The mean serum uric acid level in male is 5.5+1.26 while in female it is 5.4+1.15. They have shown that the serum UA level was more in males when related to females. In this study, serum uric acid does not correlate with Body Mass Index. The average serum UA level in hypertensive with BMI 25 are 5.38 mg/dl and 5.4 mg/dl and the difference is not statistically significant. The serum uric acid level is significantly higher in hypertensives when compared to normotensives. The average serum uric acid level in cases is 5.44mg/dl while in the control it is 3.96mg/dl. In this study, 87% of hypertensives has serum uric acid level >4mg/dl, while in controls 47% of subjects have serum uric acid level >4mg/dl. There is no significant correlation between diabetes and serum uric acid level in this study. Smoking which is also a cardiovascular risk factor does not significantly influence serum uric acid level in this study. Serum uric acid levels are significantly and independently related to increased risk of cardio-vascular mortlity. In our study coronary arterial disease is seen in 44 hypertensive individuals. The mean serum uric acid level in cases with CAD is 6+1.17.There is significant difference noticed among the cases with and without CAD. CONCLUSION: In conclusion, we decided that there can be a direct relation between hypertension and hyperuricemia based on the results of our study. Hyperuricemia is found in 15.5% of hypertensives while none of the normotensives had hyperuricemia. Serum uric acid level is significantly elevated in cases with coronary artery disease. Serum uric acid is significantly elevated in essential hypertension. There is no correlation between serum uric acid with age, sex, BMI, diabetes and smoking

Antiepileptic drugs reduce serum uric acid

Uric acid examination in 554 epileptic out-patients under long-term anticonvulsant medication revealed significantly lower serum concentrations compared to a group of normal controls. In patients taking enzyme-inducing drugs, uric acid levels were found to be lower than in those under valproate sodium. In addition, uric acid concentrations showed a negative correlation with duration of therapy in epileptic males. At this time, we can only speculate on the mechanism involved in the reduction of uric acid by enzyme-inducing anticonvulsants as well as on the possible implication of this finding in the treatment of hyperuricemia

The serum uric acid concentration is not causally linked to diabetic nephropathy in type 1 diabetes

Previous studies have shown a relationship between uric acid concentration and progression of renal disease. Here we studied causality between the serum uric acid concentration and progression of diabetic nephropathy in 3895 individuals with type 1 diabetes in the FinnDiane Study. The renal status was assessed with the urinary albumin excretion rate and estimated glomerular filtration rate (eGFR) at baseline and at the end of the follow-up. Based on previous genomewide association studies on serum uric acid concentration, 23 single nucleotide polymorphisms (SNPs) with good imputation quality were selected for the SNP score. This score was used to assess the causality between serum uric acid and renal complications using a Mendelian randomization approach. At baseline, the serum uric acid concentration was higher with worsening renal status. In multivariable Cox regression analyses, baseline serum uric acid concentration was not independently associated with progression of diabetic nephropathy over a mean follow-up of 7 years. However, over the same period, baseline serum uric acid was independently associated with the decline in eGFR. In the cross-sectional logistic regression analyses, the SNP score was associated with the serum uric acid concentration. Nevertheless, the Mendelian randomization showed no causality between uric acid and diabetic nephropathy, eGFR categories, or eGFR as a continuous variable. Thus, our results suggest that the serum uric acid concentration is not causally related to diabetic nephropathy but is a downstream marker of kidney damage.Peer reviewe

Serum uric acid as a prognostic indicator in acute ischemic stroke

Background: Association between serum uric acid (SUA) and the outcome of acute ischemic stroke is debated and needs to be evaluated. The present study was conducted to study the serum uric acid concentration as an indicator of   outcome among acute ischaemic stroke and to determine the role of serum uric acid as a risk factor for acute ischemic stroke.Methods: An observational study where 50 patients who presented within 48 hours of onset of stroke admitted to medical wards of government general Hospital Guntur were selected for the study.Results: Out of 50 patients included for the study, 6 belonged to the age group of 30-40 years. Majority were male (66%) and 44.5% of the males and 76.5% of females showed raised serum uric acid levels. 25 out of 50 patients were diabetic (i.e. 50%) Among them 16 had serum uric acid >6 mg% (ie.64%), 56% of the patients were hypertensive and among them 71% were found to have uric acid levels greater than 6mgs%, 38 out of 50 patients had bad outcome, with elevated uric acid levels found 30 among them. In the present study, BMI and outcome of Stroke were significantly associated with Serum Uric acid levels.Conclusions: Serum uric acid levels can be used as a prognostic indicator as a marker for increased risk of stroke. Elevated serum urate concentration may stratify risk of death after acute stroke

Association of serum uric acid with proteinuria in type 2 diabetic patients

Background: Various findings suggest that uric acid is an inflammatory factor and may have a role in endothelial dysfunction and act as a mediator of diabetic nephropathy. The objective of this study was to evaluate the relationships between serum uric acid level and level of proteinuria in type 2 diabetic (T2D) patients. Materials and Methods: A cross-sectional analytical study was conducted in 60 patients with T2D without a history of gout. None was treated with allopurinol. Venous blood samples were obtained in fasting state for determinations of serum creatinine, uric acid, and hemoglobin A(1c) (HbA(1c)) (reference range 3.8-5.5%); 24-h urine proteinuria was also measured. Results: Mean age of the patients was 57 +/- 8.3 years. Mean +/- standard error (SE) of serum creatinine was 0.98 +/- 0.028 mg/dL, mean +/- SE of serum uric acid was 4.5 +/- 0.15 mg/dL, and mean +/- SE of proteinuria was 388 +/- 28.7 mg/day (median = 303.5 mg/day). There was no significant difference in serum uric acid, HbA(1c), and creatinine level between males and females (P > 0.05). There was a significant positive association between body mass index (BMI) and serum uric acid levels (r = 0.428, P = 0.001). After adjustment for weight, a significant positive association of serum uric acid with level of proteinuria was seen (r = 0.47, P < 0.001). Conclusion: Serum uric acid had a significant positive association with diabetic nephropathy. It might be hypothesized that serum uric acid plays a role in diabetic nephropathy in T2D

Association between Serum Uric Acid Levels and Diabetes Mellitus

Serum uric acid has been shown to be associated with cardiovascular disease, hypertension, and chronic kidney disease in previous studies. However, few studies have examined the association between serum uric acid and diabetes mellitus and their findings are not consistent. Therefore, we examined the association between serum uric acid levels and diabetes mellitus in participants from the third National Health and Nutrition Examination Survey (n = 18, 825, 52.5% women). Serum uric acid levels were categorized into quartiles. Diabetes mellitus was defined as fasting glucose ≥126 mg/dL, nonfasting glucose ≥200 mg/dL, or use of oral hypoglycemic medication or insulin (n = 395). In multivariable logistic regression models, we found that higher serum uric acid levels were inversely associated with diabetes mellitus after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, body mass index, hypertension, and serum cholesterol. Compared to quartile 1 of serum uric acid, the odds ratio (95% confidence interval) of diabetes mellitus was 0.48 (0.35–0.66; P trend <0.0001). The results were consistent in subgroup analysis by gender and hypertension status. Higher serum uric acid levels were inversely associated with diabetes mellitus in a representative sample of US adults