1,097,401 research outputs found
Aurora, What Causes the Northern Lights?
This color brochure answers common questions about the aurora, including its cause and explanations of its colors, shapes, and location. It lists resources for further study. Educational levels: Informal education
Spatial modelling of wetness for the Antarctic Dry Valleys
This paper describes a method used to model relative wetness for part of the Antarctic Dry Valleys using Geographic Information Systems (GIS) and remote sensing. The model produces a relative index of liquid water availability using variables that influence the volume and distribution of water. Remote sensing using Moderate Resolution Imaging Spectroradiometer (MODIS) images collected over four years is used to calculate an average index of snow cover and this is combined with other water sources such as glaciers and lakes. This water source model is then used to weight a hydrological flow accumulation model that uses slope derived from Light Detection and Ranging (LIDAR) elevation data. The resulting wetness index is validated using three-dimensional visualization and a comparison with a high-resolution Advanced Land Observing Satellite image that shows drainage channels. This research demonstrates that it is possible to produce a wetness model of Antarctica using data that are becoming widely available
Are polar rings indeed polar?
We have considered polar ring galaxy candidates, the images of which can be
found in the SDSS. The sample of 78 galaxies includes the most reliable
candidates from the SPRC and PRC catalogs, some of which already have kinematic
confirmations. We analyze the distributions of studied objects by the angle
between the polar ring and the central disk, and by the optical diameter of the
outer ring structures. In the vast majority of cases, the outer structures lie
in the plane close to polar (within 10-20 deg) which indicates the stability of
the corresponding orbits in the gravitational potential of the halo. Moderately
inclined outer structures are observed only in about 6% of objects which
probably indicates their short lifetime. In such an unstable configuration, the
polar ring would often cross the disk of the galaxy, being smaller than it in
the diameter. We show that the inner polar structures and outer large-scale
polar rings form a single family in the distribution of diameters normalized to
the optical size of the galaxy. At the same time, this distribution is bimodal,
as the number of objects with d_ring= (0.4-0.7)*d_disk is negligible. Such a
shape of size distribution is most likely due to the fact that the stability of
polar orbits in the inner regions of galaxies is maintained by the bulge or the
bar, while in the outer regions it is provided by the spheroidal (or triaxial)
halo.Comment: Corrected version accepted in Astrophysical Bulletin, 8 pages, 5 EPS
figure
EarlyR: A Robust Gene Expression Signature for Predicting Outcomes of Estrogen Receptor–Positive Breast Cancer
Introduction
Early stage estrogen receptor (ER)-positive breast cancer may be treated with chemotherapy in addition to hormone therapy. Currently available molecular signatures assess the risk of recurrence and the benefit of chemotherapy; however, these tests may have large intermediate risk groups, limiting their usefulness.
Methods
The EarlyR prognostic score was developed using integrative analysis of microarray data sets and formalin-fixed, paraffin-embedded–based quantitative real-time PCR assay and validated in Affymetrix data sets and METABRIC cohort using Cox proportional hazards models and Kaplan-Meier survival analysis. Concordance index was used to measure the probability of prognostic score agreement with outcome.
Results
The EarlyR score and categorical risk strata (EarlyR-Low, EarlyR-Int, EarlyR-High) derived from expression of ESPL1, MKI67, SPAG5, PLK1 and PGR was prognostic of 8-year distant recurrence-free interval in Affymetrix (categorical P = 3.5 × 10−14; continuous P = 8.8 × 10−15) and METABRIC (categorical P < 2.2 × 10−16; continuous P < 10−16) data sets of ER+ breast cancer. Similar results were observed for the breast cancer–free interval end point. At most 13% of patients were intermediate risk and at least 66% patients were low risk in both ER+ cohorts. The EarlyR score was significantly prognostic (distant recurrence-free interval; P < .001) in both lymph node–negative and lymph node–positive patients and was independent from clinical factors. EarlyR and surrogates of current molecular signatures were comparable in prognostic significance by concordance index.
Conclusion
The 5-gene EarlyR score is a robust prognostic assay that identified significantly fewer patients as intermediate risk and more as low risk than currently available assays. Further validation of the assay in clinical trial–derived cohorts is ongoing
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Sin resume
A combinatorial characterisation of embedded polar spaces
Some classical polar spaces admit polar spaces of the same rank as embedded
polar spaces (often arisen as the intersection of the polar space with a
non-tangent hyperplane). In this article we look at sets of generators that
behave combinatorially as the set of generators of such an embedded polar
space, and we prove that they are the set of generators of an embedded polar
space
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