Prophylactic antibiotic regimens in tumour surgery (PARITY): a pilot multicentre randomised controlled trial.

ObjectiveClinical studies of patients with bone sarcomas have been challenged by insufficient numbers at individual centres to draw valid conclusions. Our objective was to assess the feasibility of conducting a definitive multi-centre randomised controlled trial (RCT) to determine whether a five-day regimen of post-operative antibiotics, in comparison to a 24-hour regimen, decreases surgical site infections in patients undergoing endoprosthetic reconstruction for lower extremity primary bone tumours.MethodsWe performed a pilot international multi-centre RCT. We used central randomisation to conceal treatment allocation and sham antibiotics to blind participants, surgeons, and data collectors. We determined feasibility by measuring patient enrolment, completeness of follow-up, and protocol deviations for the antibiotic regimens.ResultsWe screened 96 patients and enrolled 60 participants (44 men and 16 women) across 21 sites from four countries over 24 months (mean 2.13 participants per site per year, standard deviation 2.14). One participant was lost to follow-up and one withdrew consent. Complete data were obtained for 98% of eligible patients at two weeks, 83% at six months, and 73% at one year (the remainder with partial data or pending queries). In total, 18 participants missed at least one dose of antibiotics or placebo post-operatively, but 93% of all post-operative doses were administered per protocol.ConclusionsIt is feasible to conduct a definitive multi-centre RCT of post-operative antibiotic regimens in patients with bone sarcomas, but further expansion of our collaborative network will be critical. We have demonstrated an ability to coordinate in multiple countries, enrol participants, maintain protocol adherence, and minimise losses to follow-up. Cite this article: Bone Joint Res;4:154-162

Cubic interactions of massless bosonic fields in three dimensions II: Parity-odd and Chern-Simons vertices

This work completes the classification of the cubic vertices for arbitrary spin massless bosons in three dimensions started in a previous companion paper by constructing parity-odd vertices. Similarly to the parity-even case, there is a unique parity-odd vertex for any given triple $s_1\geq s_2\geq s_3\geq 2$ of massless bosons if the triangle inequalities are satisfied ($s_1<s_2+s_3$) and none otherwise. These vertices involve two (three) derivatives for odd (even) values of the sum $s_1+s_2+s_3$. A non-trivial relation between parity-even and parity-odd vertices is found. Similarly to the parity-even case, the scalar and Maxwell matter can couple to higher spins through current couplings with higher derivatives. We comment on possible lessons for 2d CFT. We also derive both parity-even and parity-odd vertices with Chern-Simons fields and comment on the analogous classification in two dimensions.Comment: 29 page

Derivation of Dark Matter Parity from Lepton Parity

It is shown that in extensions of the standard model of quarks and leptons where additive lepton number $L$ is broken by two units, so that $Z_2$ lepton parity, i.e. $(-1)^L$ which is either even or odd, remains exactly conserved, there is the possibility of stable dark matter without additional symmetry. This applies to many existing simple models of Majorana neutrino mass with dark matter, including some radiative models. Several well-known examples are discussed. This new insight leads to the construction of a radiative Type II seesaw model of neutrino mass with dark matter where the dominant decay of the doubly charged Higgs boson $\xi^{++}$ is into $W^+W^+$ instead of the expected $l_i^+ l_j^+$ lepton pairs for the well-known tree-level model.Comment: 11 pages, 6 figures, version to appear in PR

Supersymmetric Effects in Parity-Violating Deep Inelastic Electron-Nucleus Scattering

We compute the supersymmetric (SUSY) corrections to the parity-violating, deep inelastic electron-deuteron asymmetry. Working with the Minimal Supersymmetric Standard Model (MSSM) we consider two cases: R parity conserving and R parity-violating. Under these scenarios, we compare the SUSY effects with those entering other parity-violating observables. For both cases of the MSSM, we find that the magnitude of the SUSY corrections can be as large as about 1% and that they are strongly correlated with the effects on other parity-violating observables. A comparison of various low-energy parity-violating observables thus provides a potentially interesting probe of SUSY.Comment: 12 pages, 5 figure

Nearby Doorways, Parity Doublets and Parity Mixing in Compound Nuclear States

We discuss the implications of a doorway state model for parity mixing in compound nuclear states. We argue that in order to explain the tendency of parity violating asymmetries measured in $^{233}$Th to have a common sign, doorways that contribute to parity mixing must be found in the same energy neighbourhood of the measured resonance. The mechanism of parity mixing in this case of nearby doorways is closely related to the intermediate structure observed in nuclear reactions in which compound states are excited. We note that in the region of interest ($^{233}$Th) nuclei exhibit octupole deformations which leads to the existence of nearby parity doublets. These parity doublets are then used as doorways in a model for parity mixing. The contribution of such mechanism is estimated in a simple model.Comment: 11 pages, REVTE

Non-yrast nuclear spectra in a model of coherent quadrupole-octupole motion

A model assuming coherent quadrupole-octupole vibrations and rotations is applied to describe non-yrast energy sequences with alternating parity in several even-even nuclei from different regions, namely $^{152,154}$Sm, $^{154,156,158}$Gd, $^{236}$U and $^{100}$Mo. Within the model scheme the yrast alternating-parity band is composed by the members of the ground-state band and the lowest negative-parity levels with odd angular momenta. The non-yrast alternating-parity sequences unite levels of $\beta$-bands with higher negative-parity levels. The model description reproduces the structure of the considered alternating-parity spectra together with the observed B(E1), B(E2) and B(E3) transition probabilities within and between the different level-sequences. B(E1) and B(E3) reduced probabilities for transitions connecting states with opposite parity in the non-yrast alternating-parity bands are predicted. The implemented study outlines the limits of the considered band-coupling scheme and provides estimations about the collective energy potential which governs the quadrupole-octupole properties of the considered nuclei.Comment: 38 pages, 9 figure