1,216,250 research outputs found

    A novel mode of capping protein-regulation by Twinfilin

    Get PDF
    Cellular actin assembly is controlled at the barbed ends of actin filaments, where capping protein (CP) limits polymerization. Twinfilin is a conserved in vivo binding partner of CP, yet the significance of this interaction has remained a mystery. Here, we discover that the C-terminal tail of Twinfilin harbors a CP-interacting (CPI) motif, identifying it as a novel CPI-motif protein. Twinfilin and the CPI-motif protein CARMIL have overlapping binding sites on CP. Further, Twinfilin binds competitively with CARMIL to CP, protecting CP from barbed-end displacement by CARMIL. Twinfilin also accelerates dissociation of the CP inhibitor V-1, restoring CP to an active capping state. Knockdowns of Twinfilin and CP each cause similar defects in cell morphology, and elevated Twinfilin expression rescues defects caused by CARMIL hyperactivity. Together, these observations define Twinfilin as the first \u27pro-capping\u27 ligand of CP and lead us to propose important revisions to our understanding of the CP regulatory cycle

    Enhanced longitudinal mode spacing in blue-violet InGaN semiconductor laser

    Full text link
    A novel explanation of observed enhanced longitudinal mode spacing in InGaN semiconductor lasers has been proposed. It has been demonstrated that e-h plasma oscillations, which can exist in the laser active layer at certain driving conditions, are responsible for mode clustering effect. The resonant excitation of the plasma oscillations occurs due to longitudinal mode beating. The separation of mode clusters is typically by an order of magnitude larger that the individual mode spacing.Comment: 3 pages, 2 figure

    Observation of Leggett's collective mode in a multi-band MgB2 superconductor

    Full text link
    We report observation of Leggett's collective mode in a multi-band MgB2 superconductor with T_c=39K arising from the fluctuations in the relative phase between two superconducting condensates. The novel mode is observed by Raman spectroscopy at 9.4 meV in the fully symmetric scattering channel. The observed mode frequency is consistent with theoretical considerations based on the first principle computations.Comment: Accepted for PR

    THz Repetition Frequency Mode-Locked Laser Using Novel Sampled Gratings

    Get PDF
    Conventional sampled grating distributed-Bragg-gratings (C-SGDBRs) are widely used in tunable DBR lasers [1], and more recently have been used to precisely control the wavelength spacing in arrays of DBR lasers for use in WDM systems [2], and as the reflectors in THz repetition frequency (Fr) semiconductor mode locked lasers (SMLLs) [3]. However, the effective coupling coefficient, κ, of a C-SGDBR (Fig. 1(a)) is necessarily reduced substantially from that of a uniform grating because much of the sampled grating period has no grating. Here, for the first time, we apply a combination of π-phase shifted gratings, previously demonstrated in fiber lasers [4], with the C-SGDBR technique to THz repetition frequency SMLLs. Using a single electron beam lithography (EBL) step we have demonstrated a 620 GHz side-wall SGDBR MLL with an increased effective κ

    Charge response function and a novel plasmon mode in graphene

    Full text link
    Polarizability of non-interacting 2D Dirac electrons has a 1/\sqrt{qv-\omega} singularity at the boundary of electron-hole excitations. The screening of this singularity by long-range electron-electron interactions is usually treated within the random phase approximation. The latter is exact only in the limit of N -> infinity, where N is the ``color'' degeneracy. We find that the ladder-type vertex corrections become crucial close to the threshold as the ratio of the n-th order ladder term to the same order RPA contribution is (\ln|qv-\omega|)^n/N^n$. We perform analytical summation of the infinite series of ladder diagrams which describe excitonic effect. Beyond the threshold, qv>\omega, the real part of the polarization operator is found to be positive leading to the appearance of a strong and narrow plasmon resonance.Comment: 4 pages, 3 figures,typos correcte
    • …
    corecore