Overcharging: The Crucial Role of Excluded Volume

In this Letter we investigate the mechanism for overcharging of a single spherical colloid in the presence of aqueous salts within the framework of the primitive model by molecular dynamics (MD) simulations as well as integral-equation theory. We find that the occurrence and strength of overcharging strongly depends on the salt-ion size, and the available volume in the fluid. To understand the role of the excluded volume of the microions, we first consider an uncharged system. For a fixed bulk concentration we find that upon increasing the fluid particle size one strongly increases the local concentration nearby the colloidal surface and that the particles become laterally ordered. For a charged system the first surface layer is built up predominantly by strongly correlated counterions. We argue that this a key mechanism to produce overcharging with a low electrostatic coupling, and as a more practical consequence, to account for charge inversion with monovalent aqueous salt ions.Comment: 7 pages, 3 figs (4 EPS files). To appear in Europhysics Letter

Hydrogen Embrittlement of Aluminum: the Crucial Role of Vacancies

We report first-principles calculations which demonstrate that vacancies can combine with hydrogen impurities in bulk aluminum and play a crucial role in the embrittlement of this prototypical ductile solid. Our studies of hydrogen-induced vacancy superabundant formation and vacancy clusterization in aluminum lead to the conclusion that a large number of H atoms (up to twelve) can be trapped at a single vacancy, which over-compensates the energy cost to form the defect. In the presence of trapped H atoms, three nearest-neighbor single vacancies which normally would repel each other, aggregate to form a trivacancy on the slip plane of Al, acting as embryos for microvoids and cracks and resulting in ductile rupture along the these planes.Comment: To appear in Phys. Rev. Let

Crucial Role of Quantum Entanglement in Bulk Properties of Solids

We demonstrate that the magnetic susceptibility of strongly alternating antiferromagnetic spin-1/2 chains is an entanglement witness. Specifically, magnetic susceptibility of copper nitrate (CN) measured in 1963 (Berger et al., Phys. Rev. 132, 1057 (1963)) cannot be described without presence of entanglement. A detailed analysis of the spin correlations in CN as obtained from neutron scattering experiments (Xu et al., Phys. Rev. Lett. 84, 4465 (2000)) provides microscopic support for this interpretation. We present a quantitative analysis resulting in the critical temperature of 5K in both, completely independent, experiments below which entanglement exists.Comment: 4 pages, 2 figure

Macroion adsorption: The crucial role of excluded volume and coions

The adsorption of charged colloids (macroions) onto an oppositely charged planar substrate is investigated theoretically. Taking properly into account the finite size of the macroions, unusual behaviors are reported. It is found that the role of the coions (the little salt-ions carrying the same sign of charge as that of the substrate) is crucial to understand the mechanisms involved in the process of macroion adsorption. In particular, the coions can accumulate near the substrate's surface and lead to a counter-intuitive {\it surface charge amplification}.Comment: 11 pages - 4 figures. To appear in JC

Iron metabolism in trypanosomatids, and its crucial role in infection.

Iron is almost ubiquitous in living organisms due to the utility of its redox chemistry. It is also dangerous as it can catalyse the formation of reactive free radicals - a classical double-edged sword. In this review, we examine the uptake and usage of iron by trypanosomatids and discuss how modulation of host iron metabolism plays an important role in the protective response. Trypanosomatids require iron for crucial processes including DNA replication, antioxidant defence, mitochondrial respiration, synthesis of the modified base J and, in African trypanosomes, the alternative oxidase. The source of iron varies between species. Bloodstream-form African trypanosomes acquire iron from their host by uptake of transferrin, and Leishmania amazonensis expresses a ZIP family cation transporter in the plasma membrane. In other trypanosomatids, iron uptake has been poorly characterized. Iron-withholding responses by the host can be a major determinant of disease outcome. Their role in trypanosomatid infections is becoming apparent. For example, the cytosolic sequestration properties of NRAMP1, confer resistance against leishmaniasis. Conversely, cytoplasmic sequestration of iron may be favourable rather than detrimental to Trypanosoma cruzi. The central role of iron in both parasite metabolism and the host response is attracting interest as a possible point of therapeutic intervention

The crucial role of surface magnetic fields for the solar dynamo

Sunspots and the plethora of other phenomena occuring in the course of the 11-year cycle of solar activity are a consequence of the emergence of magnetic flux at the solar surface. The observed orientations of bipolar sunspot groups imply that they originate from toroidal (azimuthally orientated) magnetic flux in the convective envelope of the Sun. We show that the net toroidal magnetic flux generated by differential rotation within a hemisphere of the convection zone is determined by the emerged magnetic flux at the solar surface and thus can be calculated from the observed magnetic field distribution. The main source of the toroidal flux is the roughly dipolar surface magnetic field at the polar caps, which peaks around the minima of the activity cycle.Comment: This manuscript has been accepted for publication in Science. This version has not undergone final editing. Please refer to the complete version of record at http://www.sciencemag.org/. The manuscript may not be reproduced or used in any manner that does not fall within the fair use provisions of the Copyright Act without the prior, written permission of AAA