MOESM1 of ZIF-67-Derived CoSe/NC Composites as Anode Materials for Lithium-Ion Batteries

Additional file 1. Figure S1. SEM image of as-synthesized ZIF-67. Figure S2. C 1s spectrum of CoSe/NC. Figure S3. The EDS spectrum of CoSe/NC. Figure S4. CV curves of pure CoSe at 0.2 mV s-1. Table S1. Percentages of elements in CoSe/NC

Additional file 1: of MOF-Derived ZnSe/N-Doped Carbon Composites for Lithium-Ion Batteries with Enhanced Capacity and Cycling Life

Figure S1. SEM images of ZIF-8 at different sizes (a) ZIF-900, (b) ZIF-300, (c) ZIF-40, and (d) the XRD patterns of synthesized ZIF-8 at different sizes and simulated XRD pattern. Figure S2. (a, b) TEM images of ZnSe/NC-900 and ZnSe/NC-40, respectively, (c, d) HRTEM images of ZnSe/NC-900 and ZnSe/NC-40, respectively, (e, f) SAED images of ZnSe/NC-900 and ZnSe/NC-40, respectively. Figure S3. XPS survey spectra of ZnSe/NC-300. Figure S4. (a, b) Nitrogen adsorption-desorption isotherms of ZnSe/NC-900 and ZnSe/NC-40, respectively, (c, d) their pore diameter distribution profiles. Figure S5. The first three cyclic CV cures of (a) pure ZnSe, (b) ZnSe/NC-900, and (c) ZnSe/NC-40 at a scan rate of 0.2 mV/s in the range of 0.01–3.0 V. Figure S6. Galvanostatic discharge/charge voltage profiles of (a) pure ZnSe, (b) ZnSe/NC-900, (c) ZnSe/NC-40 at a current density of 100 mA g−1. Figure S7. EIS spectra of pure ZnSe, ZnSe/NC-900, ZnSe/NC-300, and ZnSe/NC-40 after 100 cycles. Table S1. Comparison of ZnSe/NC composites and other metal selenides as LIB anodes. (DOC 2425 kb

Concentration and size distribution of particulate matter in a new aviary system for laying hens in China

Particulate matter (PM) from poultry production facilities may strongly affect the health of animals and workers in the houses, and PM emitted to the ambient air is an important pollution source to the surrounding areas. Aviary system is considered as a welfare friendly production system for laying hens. However, its air quality is typically worse as compared with conventional cage systems, because of the higher PM concentration of indoor air and other airborne contaminants. Furthermore, PM’s physical property, which has a direct impact on the penetration depth into the lungs of the birds and humans, is largely unknown for the aviary system. Therefore, a systematic method was utilized to investigate the characteristics of particles in the aviary house with large cage aviary unit system (LCAU) in Beijing, China. For the field measurements, three measuring locations were selected with two inside and one outside the house with LCAU to continuously monitor PM concentrations and collect the samples for particle size distribution (PSD) analysis. Results showed that PM2.5, PM10, and total suspended particulate (TSP) concentrations averaged at 0.037 ± 0.025 mg/m3, 0.42 ± 0.10 mg/m3, and 1.92 ± 1.91 mg/m3, respectively. Particle concentrations increased from October to December due to less ventilation as the weather got colder, and were generally affected by stocking density, ventilation rate, birds’ activities, and housing system. Meanwhile, indoor PM2.5 concentration was easily impacted by the ambient air quality. Mass median diameter (MMD) and mass geometric standard deviation (MGSD) of the TSP during the measurement were 18.92 ± 7.08 μm and 3.11 ± 0.31, respectively. Count median diameter (CMD) and count geometric standard deviation (CGSD) were 1.94 ± 0.14 μm and 1.48 ± 0.08, respectively. Results indicated that the aviary system can attain a good indoor condition by suitable system design and environment control strategy. Implications: Indoor PM2.5 concentration of the layer house can be significantly affected by ambient air quality when the air quality index (AQI) was larger than 100. PM2.5 and PM10 concentrations of the layer house with a LCAU system were comparable to the cage system. TSP concentration was higher, and PM size was larger than most of the cage system. System design, larger space volume, and higher ventilation rate were the main influence factors. Good indoor environment of the aviary system can be achieved through the reasonable design of the production system and appropriate environment control strategy.</p

Reaction of Phospholes with Aldimines: A One-Step Synthesis of Chelating, Alpha‑C₂‑Bridged Biphospholes

Phospholes react with aldimines at 170 °C in the presence of mild Lewis acids to give C₂-bridged biphospholes in good yields. The mechanism includes a series of [1,5] shifts of the P-substituents around the phosphole ring, a P–H + aldimine condensation, and the formation of a transient three-membered ring that dimerizes

Reaction of Phospholes with Aldimines: A One-Step Synthesis of Chelating, Alpha‑C₂‑Bridged Biphospholes

Phospholes react with aldimines at 170 °C in the presence of mild Lewis acids to give C₂-bridged biphospholes in good yields. The mechanism includes a series of [1,5] shifts of the P-substituents around the phosphole ring, a P–H + aldimine condensation, and the formation of a transient three-membered ring that dimerizes

Datasheet1_Femoral neck system vs. cannulated screws on treating femoral neck fracture: a meta-analysis and system review.docx

ObjectiveThis meta-analysis aimed to compare the relative safety and efficacy of cannulated compression screw (CCS) and femoral neck system (FNS) in treating patients with femoral neck fractures and to provide evidence-based medical evidence for FNS in treating femoral neck fractures.MethodsPubMed, Embase, Cochrane, and China National Knowledge Infrastructure databases were searched to collect outcomes related to femoral neck fractures treated with FNS and CCS, including time to fracture healing, incidence of non-union, incidence of osteonecrosis of the femoral head, incidence of failure of internal fixation, rate of femoral neck shortening, Harris hip score, Barthel index, operative time, intraoperative blood loss, fluoroscopy frequency, and complications. A meta-analysis was performed using RevManv5.4 (The Cochrane Collaboration) and Stata v14.0 software.ResultsThis analysis included 21 studies involving 1,347 patients. The results showed that FNS was superior to CCS in terms of fracture healing time [mean difference (MD) = −0.75, 95% CI = (−1.04, −0.46), P  0.05], Harris hip score [MD = 3.31, 95% CI = (1.99, 4.63), P ConclusionFNS treatment of femoral neck fracture can shorten the fracture healing time; reduce the incidence and translucent rate of bone non-union, osteonecrosis of the femoral head, and internal fixation failure; reduce intraoperative blood loss and postoperative complications; and improve hip joint function and activity. We are confident in the findings that FNS, an effective and safe procedure for internal fixation of femoral neck fractures, is superior to CCS.</p

Pd/C Catalyzed Carbonylation of Azides in the Presence of Amines

A facile and efficient Pd/C-catalyzed carbonylation of both aliphatic and aromatic azides in the presence of amines is reported. Serving as the widely existed fragments in an array of biological pharmaceuticals, functionalized unsymmetrical ureas were straightforwardly synthesized by using readily available and cheap azides with amines under CO atmosphere, with the extrusion of N₂ as the only byproduct. It was found that not only aryl azides but also benzyl and alkyl azides were suited for this methodology. Another feature of this procedure was the employment of a highly efficient palladium charcoal catalytic system

Presentation1_Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2.ZIP

Introduction: Due to its highly aggressiveness and malignancy, glioblastoma (GBM) urgently requires a safe and effective treatment strategy. Zeylenone, a natural polyoxygenated cyclohexenes compound isolated from Uvaria grandiflora, has exhibited potential biological activities in various human diseases, including tumors.Methods: We designed and synthesized a series of (+)-Zeylenone analogues and evaluated their anti-GBM roles through structural-activity analysis. Cell Counting Kit-8, TUNEL, transwell and flow cytometry were employed for investigating the anticancer effects of CA on GBM cells. Western blotting, molecular docking, qRT-PCR and ChIP assays were performed to reveal the underlying mechanisms by which CA regulates the GBM cell cycle. The nude mouse xenograft model, HE staining, immunohistochemistry and was used to evaluate the anticancer effect of CA in vivo.Results: We identified CA ((1R, 2R, 3S)-3-p-fluorobenzoyl-zeylenone) as having the lowest IC50 value in GBM cells. CA treatment significantly inhibited the malignant behaviors of GBM cells and induced G0/G1 phase arrest in vitro. Furthermore, we validated the molecular mechanism by which CA interferes with EZH2, attenuating the down-regulation of cyclin-dependent kinase inhibitors p27 and p16 by the PRC2 complex. By establishing orthotopic nude mice models, we further validated the inhibitory role of CA on tumorigenesis of GBM cells in vivo and its potential values to synergistically potentiate the anti-tumor effects of EZH2 inhibitors.Conclusion: Overall, this paper elucidated the anti-GBM effects and potential mechanisms of CA, and may provide a therapeutic drug candidate for GBM treatment.</p

Data_Sheet_1_Association Between Pre-operative BUN and Post-operative 30-Day Mortality in Patients Undergoing Craniotomy for Tumors: Data From the ACS NSQIP Database.CSV

ObjectiveThere is limited evidence to clarify the specific relationship between pre-operative blood urea nitrogen (BUN) and post-operative 30-day mortality in patients undergoing craniotomy for tumors. Therefore, we aimed to investigate this relationship in detail.MethodsElectronic medical records of 18,642 patients undergoing craniotomy for tumors in the ACS NSQIP from 2012 to 2015 were subjected to secondary retrospective analysis. The principal exposure was pre-operative BUN. Outcome measures were post-operative 30-day mortality. We used binary logistic regression modeling to evaluate the association between them and conducted a generalized additive model and smooth curve fitting (penalized spline method) to explore the potential relationship and its explicit curve shape. We also conducted sensitivity analyses to ensure the robustness of the results and performed subgroup analyses.ResultsA total of 16,876 patients were included in this analysis. Of these, 47.48% of patients were men. The post-operative 30-day mortality of the included cases was 2.49% (420/16,876), and the mean BUN was 16.874 ± 6.648 mg/dl. After adjusting covariates, the results showed that pre-operative BUN was positively associated with post-operative 30-day mortality (OR = 1.020, 95% CI: 1.004, 1.036). There was also a non-linear relationship between BUN and post-operative 30-day mortality, and the inflection point of the BUN was 9.804. For patients with BUN 9.804 mg/dl, a 1 unit increase in BUN was related to a 2.8% increase in the risk of post-operative 30-day mortality (OR = 1.028, 95% CI: 1.011, 1.045). The sensitivity analysis proved that the results were robust. The subgroup analysis revealed that all listed subgroups did not affect the relationship between pre-operative BUN and post-operative 30-day mortality (P > 0.05).ConclusionOur study demonstrated that pre-operative BUN (mg/dl) has specific linear and non-linear relationships with post-operative 30-day mortality in patients over 18 years of age who underwent craniotomy for tumors. Proper pre-operative management of BUN and maintenance of BUN near the inflection point (9.804 mg/dl) could reduce the risk of post-operative 30-day mortality in these cases.</p