Percentages of the types of alternative splice sites.

<p>The splice sites include GT-AG, GC-AG, GG-AG, GT-GG, and the others (a) in human cancer (b) and normal tissues. (c) Percentage distribution of the splice sites in five types of cancer and normal tissues (brain, breast, lung, liver, and prostate).</p

A schematic representation of cancer-specific alternative gene splicing.

<p>(a) Brain cancer (gene ACYl), (b) breast cancer (SRP19), (c) liver cancer (CDK5), (d) lung cancer (CDKN1A), and (e) prostate cancer (SMS). Cancer-specific isoforms are showed on the bottom in each panel. The biological processes of these transcripts (GO process) are indicated on the right. Deleted domains are shown with blue arrows. Arrows with a right angle indicate the start codon, ATG.</p

Oncogenes and tumor suppressors with cancer-specific AS events.

<p>Oncogenes and tumor suppressors with cancer-specific AS events.</p

Numbers of libraries and ESTs in normal tissues.

<p>Numbers of libraries and ESTs in normal tissues.</p

The frequencies (percentages) of the five types of cancer- and normal tissue-specific alternative splicing.

<p>(a) 16 types of human cancer and 17 normal tissues, (b) the average values between tumors and normal tissues. The five colors indicate the five types of tissue-specific alternative splicing: cassette alternative exon, alternative 5′ splice site, alternative 3′ splice site, intron retention, and mutually exclusive alternative exons. Yellowish regions indicate over 30% of the frequencies.</p

Numbers of cancer-specific AS transcripts and their genes.

<p>Numbers of cancer-specific AS transcripts and their genes.</p

Numbers of normal tissue-specific AS transcripts and their genes.

<p>Numbers of normal tissue-specific AS transcripts and their genes.</p

Numbers of libraries and ESTs in cancers.

<p>Numbers of libraries and ESTs in cancers.</p

A database of cancer- and normal tissue-specific alternative splicing.

<p>An example page set from the database shows the details of an adrenal cancer gene, FDPS. The information includes the specific alternative splicing of both cancer and normal tissues, gene ID, gene structure, splicing sites, chromosome localization, DNA and protein sequences linked with the NCBI website, and GO process, function, and subcellular localization.</p

Biological processes of alternatively spliced transcripts specific to cancer.

<p>The five cancer types are brain, breast, liver, lung, and prostate cancer. The numbers indicate the percentages for each process in the cancer. The GO process classification is based on the PANTHER (<a href="http://www.pantherdb.org/tools/genexAnalysis.jsp" target="_blank">http://www.pantherdb.org/tools/genexAnalysis.jsp</a>).</p