Additional file 1 of Assessing Epstein–Barr virus in gastric cancer: clinicopathological features and prognostic implications

Additional file1. Relationship between EBV infection and clinicopathologic characteristics

Additional file 3 of Assessing Epstein–Barr virus in gastric cancer: clinicopathological features and prognostic implications

Additional file3. Analysis of univariate and multivariate factors affecting the disease-free survival of patients

Additional file 2 of Assessing Epstein–Barr virus in gastric cancer: clinicopathological features and prognostic implications

Additional file2. Univariate and multivariate analysis of overall survival-related factors

Integrated scalable metalens array for optical addressing

The scalability of optical addressing is one of the key challenges for the large-scale trapped-ion quantum computing (QC). Metasurfaces is a promising solution due to excellent optical performance, integration, and miniaturization. Here, we propose and numerically demonstrate a design of integrated scalable metalens array (ISMA) working in the UV 350nm range for optical addressing. These ISMAs can focus the collimated individual addressing beams array into diffraction-limited spots array, featuring crosstalk below 0.82%, focusing efficiency as high as 36.90%. For various applications, the x-polarized, polarization-insensitive and right-handed circularly polarized ISMA are designed. The design proposed in this paper can also find applications in optical trapping

MgO-Based Granular Sorbent Pelletized by Using Ordered Mesoporous Silica as Binder for Low-Temperature CO₂ Capture

Cyclic CO2 adsorption by using MgO as a sorbent at low temperatures is considered a promising route for postcombustion CO2 capture. However, most MgO-based sorbents are in the form of fine powder and cannot be used in a fluidized bed reactor, and at the same time, suffer from a rapid loss in CO2 uptake capacity due to the decrease of surface area aroused by pore shrinking and grain sintering. In this study, mesoporous silicas with highly ordered pore structures have been used as binders, for the first time, to fabricate MgO-based sorbent pellets via a simple and scalable extrusion–spheronization approach. The obtained MgO-based pellets exhibit high porosity attributed to the nature of the mesoporous binder, leading to a significantly increased stability and CO2 uptake capacity. Especially for the low-concentration CO2 that is comparable to the flue gas from a coal-fired power plant, the results show that the ordered mesoporous silica binder provides a remarkable promotion effect and excellent stability in the capture performance. The CO2 uptake capacity of the best-performing sorbent, 20-KIT-6–100, displays a small decline of 6.86% (from 1.02 mmol of CO2/g in the first cycle to 0.95 mmol of CO2/g in the 10th cycle). It is envisaged that mesoporous materials hold great potential to be used as binders in reinforcing the metal oxide-based sorbents for flue-gas CO2 capture in practical applications

Anisotropic Silk-Inspired Nerve Conduit with Peptides Improved the Microenvironment for Long-Distance Peripheral Nerve Regeneration

A lack of effective bioactivity to create a desirable microenvironment for peripheral nerve regeneration has been challenging in successful treatment of long-distance injuries using nerve guidance conduits (NGCs) clinically. Herein, we developed a silk-inspired phototriggered gelation system combining dual therapeutic cues of anisotropic topography and adhesive ligands for improving peripheral nerve regeneration. Importantly, enhanced cell recruitment and myelination of Schwann cells were successfully achieved by the Arg-Gly-Asp (RGD)-peptide-immobilized hydrogel scaffolds to promote axon growth. Moreover, as the orientated growth of Schwann cells and rapid axon growth were facilitated by aligned grooved micropatterns, this multifunctional bioactive system provides remarkable nerve regeneration with function recovery for long-distance nerve injury. Therefore, this bioengineered silk-inspired nerve guidance conduit delivers a platform for desirable peripheral nerve repair

Ultrasensitive Fingertip-Contacted Pressure Sensors To Enable Continuous Measurement of Epidermal Pulse Waves on Ubiquitous Object Surfaces

The fingertip-pulse waveform carries abundant information regarding human physiological condition that is fundamental for directly extracting physiological parameters. Making the surfaces of ordinary objects that are often in contact with fingertips, such as tables and computers, capable of perceiving dynamic epidermal pulse signals has great significance for accurately assessing health conditions without restrictions on time and place. Here, we demonstrate the materials and design of a nanohemispherical pressure sensor that can be attached to ubiquitous objects’ surfaces to monitor fingertip pulse. The portable sensor achieved an ultrasensitivity of 49.8 mV/Pa, a prominent response time of less than 6 ms, and long-term durability of more than 4 months. As demonstrated, the sensor is utilized to measure subtle fingertip-pulse waves and extract characteristic points of the waveform on the surface of keyboards, mobile phones, and human skin. Given the superior performance of the sensor, a real-time, wireless arteriosclerosis monitoring system is developed. By analyzing the characteristic parameters of the pulse waveforms measured from 54 volunteer participants, the antidiastole of arteriosclerosis could be instructively diagnosed. The sensor proposed in this work is expected to be a competitive alternative to current complicated medical equipment and to be extensively applied in wireless cardiovascular monitoring systems

Ultrasensitive Fingertip-Contacted Pressure Sensors To Enable Continuous Measurement of Epidermal Pulse Waves on Ubiquitous Object Surfaces

The fingertip-pulse waveform carries abundant information regarding human physiological condition that is fundamental for directly extracting physiological parameters. Making the surfaces of ordinary objects that are often in contact with fingertips, such as tables and computers, capable of perceiving dynamic epidermal pulse signals has great significance for accurately assessing health conditions without restrictions on time and place. Here, we demonstrate the materials and design of a nanohemispherical pressure sensor that can be attached to ubiquitous objects’ surfaces to monitor fingertip pulse. The portable sensor achieved an ultrasensitivity of 49.8 mV/Pa, a prominent response time of less than 6 ms, and long-term durability of more than 4 months. As demonstrated, the sensor is utilized to measure subtle fingertip-pulse waves and extract characteristic points of the waveform on the surface of keyboards, mobile phones, and human skin. Given the superior performance of the sensor, a real-time, wireless arteriosclerosis monitoring system is developed. By analyzing the characteristic parameters of the pulse waveforms measured from 54 volunteer participants, the antidiastole of arteriosclerosis could be instructively diagnosed. The sensor proposed in this work is expected to be a competitive alternative to current complicated medical equipment and to be extensively applied in wireless cardiovascular monitoring systems

<b>The Anti-inflammatory Potential of a Strain of Probiotic</b> Bifidobacterium pseudocatenulatum <b>G7:</b> <i><b>In Vitro</b></i> <b>and</b> <i><b>In Vivo</b></i> <b>Evidence</b>

The genus Bifidobacterium has been widely used in functional foods for health promotion due to its beneficial effects on human health, especially in the gastrointestinal tract (GIT). In this study, we characterize the anti-inflammatory potential of the probiotic strain Bifidobacterium pseudocatenulatum G7, isolated from a healthy male adult. G7 secretion inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Moreover, oral administration of bacteria G7 alleviated the severity of colonic inflammation in dextran sulfate sodium (DSS)-treated colitis mice, which was evidenced by a decreased disease activity index (DAI) and enhanced structural integrity of the colon. The 16S rRNA gene sequencing result illustrated that the G7 alleviated DSS-induced gut microbiota dysbiosis, accompanied by the modulated bile acids and short-chain fatty acid (SCFA) levels. Overall, our results demonstrated the potential anti-inflammatory effects of Bifidobacterium pseudocatenulatum G7 on both in vitro and in vivo models, which provided a solid foundation for further development of a novel anti-inflammatory probiotic

Ultrasensitive Fingertip-Contacted Pressure Sensors To Enable Continuous Measurement of Epidermal Pulse Waves on Ubiquitous Object Surfaces

The fingertip-pulse waveform carries abundant information regarding human physiological condition that is fundamental for directly extracting physiological parameters. Making the surfaces of ordinary objects that are often in contact with fingertips, such as tables and computers, capable of perceiving dynamic epidermal pulse signals has great significance for accurately assessing health conditions without restrictions on time and place. Here, we demonstrate the materials and design of a nanohemispherical pressure sensor that can be attached to ubiquitous objects’ surfaces to monitor fingertip pulse. The portable sensor achieved an ultrasensitivity of 49.8 mV/Pa, a prominent response time of less than 6 ms, and long-term durability of more than 4 months. As demonstrated, the sensor is utilized to measure subtle fingertip-pulse waves and extract characteristic points of the waveform on the surface of keyboards, mobile phones, and human skin. Given the superior performance of the sensor, a real-time, wireless arteriosclerosis monitoring system is developed. By analyzing the characteristic parameters of the pulse waveforms measured from 54 volunteer participants, the antidiastole of arteriosclerosis could be instructively diagnosed. The sensor proposed in this work is expected to be a competitive alternative to current complicated medical equipment and to be extensively applied in wireless cardiovascular monitoring systems