Flexible Cathode Enabled by Ultralong Na₂V₆O₁₆·3H₂O Nanowire for High Rate and Durable Aqueous Zinc Ion Batteries

Aqueous zinc ion batteries (ZIBs) have garnered increasing attention owing to their safe aqueous electrolyte and suitable energy and power density. However, the development of appropriate cathode materials for commercialization remains a challenge. Herein, we report a flexible binder-free film cathode composed of hydrated sodium vanadate nanowires and carbon nanotubes (NaVO/CNT). The as-prepared film cathode exhibits a remarkably high rate performance, delivering a capacity of 402 mAh g–1 at 0.1 A g–1 and 284 mAh g–1 at 6 A g–1. Furthermore, excellent long-term stability is achieved with a retention rate of 90.04% after 5000 cycles at 4 A g–1. This cathode demonstrates outstanding performance compared with those of other sodium vanadate-based cathodes in aqueous ZIBs. Additionally, the co(de)insertion mechanism of H+ and Zn2+ ions is verified

All-Optical Modulation of a Graphene-Cladded Silicon Photonic Crystal Cavity

The combination of graphene and a silicon photonic crystal cavity provides an ideal structure for realizing sensitive all-optical modulation. In this paper, an all-optical tuning of a graphene-cladded photonic crystal cavity is demonstrated. A 3.5 nm resonance wavelength shift and a 20% quality factor change are observed as a 1064 nm continuous-wave control laser is focused on the cavity. The resonance wavelength shift is nearly 2 times that realized with electrical modulation and can be further improved with increasing laser power. Meanwhile, it is found that the laser power to reach the saturation absorption state of graphene is nearly 2 orders of magnitude lower than that for monolayer graphene on silica. The experimental results are attributed to optically induced transparency and hot carrier effects. This study opens up a promising way to construct a sensitive all-optical modulator, which is a necessary device in an all-optical integrated circuit, by using a graphene-cladded photonic crystal cavity

Table_1_Identification of Hub Genes Associated With the Development of Stomach Adenocarcinoma by Integrated Bioinformatics Analysis.docx

ObjectiveThis study was conducted in order to gain a better understanding of the molecular mechanisms of stomach adenocarcinoma (STAD), which is necessary to predict the prognosis of STAD and develop novel gene therapy strategies.MethodsIn this study, the gene expression profile of GSE118916 in the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas Program (TCGA) was used to explore the differential co-expression genes of STAD and normal tissues.ResultsA total of 407 STAD samples were collected, consisting of 375 from stomach adenocarcinoma tissues and 32 from normal tissues, as well as RNA-seq count data for 19,600 genes. Forty-two differentially expressed genes were screened by weighted gene co-expression network analysis (WGCNA) and differentially expressed gene analysis. According to the functional annotation analysis of the clusterProfiler R package, these genes were analyzed for GO function enrichment, digestion (biological process), tube bottom material membrane (cell component), and oxidoreductase activity (molecular function). The KEGG pathway was enriched in gastric acid secretion and chemical carcinogenesis. In addition, Cytoscape’s cytoHubba plug-in was used to identify seven hub genes (EWSR1, ESR1, CLTC, PCMT1, TP53, HUWE1, and HDAC1) in a protein–protein interaction (PPI) network consisting of 7 nodes and 11 edges. Compared with normal tissues, CLTC and TP53 genes were upregulated in stomach adenocarcinoma (P ConclusionIn summary, we believe that the identified hub genes were related to the occurrence of stomach adenocarcinoma, especially the expression of ESR1, HDAC1, and CLTC genes, which are related to the prognosis and overall survival of patients and may become the potential for the future diagnosis and treatment of STAD.</p

Effects of seed crystal concentration, pH, and stirring rate on ammonium sulfate crystallization under the action of ammonium nitrate

In order to explore the effect of ammonium nitrate on the crystallization of ammonium sulfate mother liquor, this paper selected crystal seed, pH and stirring rate as the influencing factors, and studied the changes of average particle size, morphology and phase structure of ammonium sulfate crystals under the action of ammonium nitrate. When the seed crystal concentration was 1%–2%, the solute growth of the mixed solution could effectively reduce the supersaturation during the evaporation process, and the crystal growth did not generate new crystal nuclei, interfering with the crystallization process. A pH value of 4–5 promotes solvent/crystal surface interaction and crystal surface growth, which is beneficial for obtaining high-quality crystals. At a stirring rate of 200–300 r/min, the nucleation rate and secondary nucleation were improved, which is conducive to solid–liquid separation.</p

Additional file 1 of Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain

Additional file 1: Fig. S1. CRS leads to a decrease in claudin-5 expression in the (a) hippocampus; (b) prefrontal cortex (PFC) and (c) nucleus accumbens (Nac). Data are expressed as mean ± SD, Student’s t-test, *p < 0.05 compared with control. Fig. S2. CRS increases the accumulation of CD4+IL17A+ T cells in the dorsal striatum. Representative confocal images of CD4+IL17A+ T cells in the (a) DLS and (b) DMS; Cell counting of CD4+IL17A+ cells in the (c) DLS and (d) DMS. Scale bar, 20 μm. Data are expressed as mean ± SD, Student’s t-test, **p < 0.01 and ***p < 0.001 compared with control. Fig. S3. The gating strategy to identify Th17 cells. CD4+IL17A+ cells were selected from CD3+ T cells and gating with IL-17A staining and FMO control. Fig. S4. SR1001 prevents CRS-induced morphological changes in glial cells. SR1001 prevents CRS-induced morphological changes in (a) astrocytes and (b) microglia near the BBB in the DLS and DMS; (c) and (d) Quantification of morphological changes in astrocytes and microglia. Scale bar, 20 μm. Data are expressed as mean ± SD, Student’s t-test

MOESM1 of Self-nanoemulsifying system improves oral absorption and enhances anti-acute myeloid leukemia activity of berberine

Additional file 1: Figure S1. Effect of a series of berberine and cytarabine solutions on the Jurkat cell line at (A) 24 h and (B) 48 h. The data are expressed as the mean ± S.D. (n = 3); ***P < 0.001, **P < 0.01, and *P < 0.01. Vs: compare with 10 μg/mL berberine. Figure S2. Effect of a series of berberine and cytarabine solutions on the HL-60 cell line at (A) 24 h and (B) 48 h. The data are expressed as the mean ± S.D. (n = 3); ***P < 0.001, **P < 0.01, and *P < 0.01. Vs: compare with 10 μg/mL berberine

Angiogenic Microspheres for the Treatment of a Thin Endometrium

The poor vascular development of an endometrium is the key cause of a thin endometrium due to the vascular endothelial growth factor (VEGF) decreasing in the glandular epithelium. Hence, inducing angiogenesis is an effective strategy for thin endometrium treatment in clinic. Herein, we developed a novel angiogenic hydrogel microsphere based on methacrylated hyaluronic acid (HAMA) loaded with VEGF for the treatment of a thin endometrium by a microfluidic electrospray technique. The generated HAMA microspheres with uniform size, porous structure, and satisfactory biocompatibility increased the drug-loading ability and controlled the drug-release rate by adjusting the hydrogel concentration. Besides, the HAMA microspheres loaded with VEGF showed satisfactory biocompatibility and promoted blood vessel formation in vitro. More importantly, the combination of HA and VEGF promoted new blood vessels and endometrial regeneration of a thin endometrium in vivo. Therefore, the combination of HA and VEGF would be conducive to the development of a drug-delivery microsphere with excellent biocompatibility and therapeutic effect for thin endometrium treatment and other biomedical applications

Spring-Like Pseudoelectroelasticity of Monocrystalline Cu₂S Nanowire

Prediction from the dual-phase nature of superionic conductorsboth solid and liquid-likeis that mobile ions in the material may experience reversible extraction–reinsertion by an external electric field. However, this type of pseudoelectroelasticity has not been confirmed in situ, and no details on the microscopic mechanism are known. Here, we in situ monitor the pseudoelectroelasticity of monocrystalline Cu2S nanowires (NWs) using transmission electron microscopy (TEM). Specifically, we reveal the atomic scale details including phase transformation, migration and redox reactions of Cu+ ions, nucleation, growth, as well as spontaneous shrinking of Cu protrusion. Caterpillar-diffusion-dominated deformation is confirmed by the high-resolution transmission electron microscopy (HRTEM) observation and ab initio calculation, which can be driven by either an external electric field or chemical potential difference. The observed spring-like behavior was creatively adopted for electric nanoactuators. Our findings are crucial to elucidate the mechanism of pseudoelectroelasticity and could potentially stimulate in-depth research into electrochemical and nanoelectromechanical systems

The route of deriving Ixabepilone (approved in 2009) from natural product epothilone B.

<p>The route of deriving Ixabepilone (approved in 2009) from natural product epothilone B.</p