Controlling Metal Clusters in Breathing Metal–Organic Framework Nanostructures for Boosting Visible-Light-Induced ·OH Radical Formation

In recent years, traces of pharmaceuticals with high environmental risks have been reported in water cycles. Conventional wastewater treatment processes are largely ineffective in eliminating these micropollutants. Advanced wastewater treatment processes have great potential to achieve high removal rates. Thus, metal cluster (Fe-oxo, Al-oxo, and Cr-oxo)-induced ROS formation via heterogeneous catalysts was explored in an antibiotic degradation process. In this study, we synthesized a series of MIL-53 with one-dimensional photo-induced mixed-valence metal chains containing three selected clusters. Results show that the advanced oxidation performance is highly metal-dependent. Fe-oxo and Cr-oxo can significantly promote the photo-Fenton process. Also, Al-oxo can serve as a promising heterogeneous Fenton-like catalyst. Systematical characterizations of these materials were given including UV–vis DRS, Tauc’s plot, and transient photocurrent analysis. Fe/Cr-based metal–organic frameworks convey obvious visible-light photo-Fenton performance by excellent light absorption properties and high ROS production ability with an averaged separated metal atom center. The Al-based one can promote acetaminophen degradation by the formation and decomposition of H2O–H2O2 substitution coordinated to an Al atom. All these isostructural materials can promote the acetaminophen degradation process effectively by boosting ·OH production

Formal Gold- and Rhodium-Catalyzed Regiodivergent C–H Alkynylation of 2‑Pyridones

Formal regiodivergent C–H alkynylation of 2-pyridones bearing different <i>N</i>-substituents has been realized under Au­(I) and Rh­(III) catalysis using a hypervalent iodine alkyne reagent. When catalyzed by Au­(I), the alkynylation occurred at the most electron-rich 5-position via an electrophilic alkynylation pathway. The selectivity was switched to the 6-position under assistance of an <i>N</i>-chelation group when a Rh­(III) catalyst was employed. A rhodacylic complex has been isolated as a key intermediate

sj-pdf-1-opp-10.1177_10781552221127698 - Supplemental material for Comparison of permeabilities of eight different types of cytotoxic drugs to five gloves with different materials by LC-MS/MS methods to reduce occupational exposure of medical personnel

Supplemental material, sj-pdf-1-opp-10.1177_10781552221127698 for Comparison of permeabilities of eight different types of cytotoxic drugs to five gloves with different materials by LC-MS/MS methods to reduce occupational exposure of medical personnel by Hailong Zhou, Yunyun Li and Fan Xu in Journal of Oncology Pharmacy Practice</p

Access to Quaternary Stereogenic Centers via Rhodium(III)-Catalyzed Annulations between 2‑Phenylindoles and Ketenes

Rh­(III)-catalyzed C–H activation of arenes and mild oxidative [4 + 2] annulative coupling with ketenes have been realized. The uniquely high reactivity of the C(3) of 2-phenylindoles was successfully utilized to facilitate the reductive elimination process, leading to efficient synthesis of cyclic products with a quaternary carbon stereocenter

Rh(III)-Catalyzed C–C/C–N Coupling of Imidates with α‑Diazo Imidamide: Synthesis of Isoquinoline-Fused Indoles

Imidate esters and diazo compounds have been established as bifunctional substrates for the construction of biologically active fused heterocycles via rhodium-catalyzed C–H activation and C–C/C–N coupling. This reaction occurs under mild conditions with high efficiency, step economy, and low catalyst loading

Rh(III)-Catalyzed C–C/C–N Coupling of Imidates with α‑Diazo Imidamide: Synthesis of Isoquinoline-Fused Indoles

Imidate esters and diazo compounds have been established as bifunctional substrates for the construction of biologically active fused heterocycles via rhodium-catalyzed C–H activation and C–C/C–N coupling. This reaction occurs under mild conditions with high efficiency, step economy, and low catalyst loading

Access to Structurally Diverse Quinoline-Fused Heterocycles via Rhodium(III)-Catalyzed C–C/C–N Coupling of Bifunctional Substrates

Rhodium­(III)-catalyzed C–H activation of heteroarenes and functionalization with bifunctional substrates such as anthranils allows facile construction of quinoline-fused heterocycles under redox-neutral conditions. The couplings feature broad substrate scope and provide step-economical access to two classes of quinoline-fused condensed heterocycles

DataSheet_1_A comparative study of genotyping and antimicrobial resistance between carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii isolates at a tertiary pediatric hospital in China.pdf

BackgroundCarbapenem-resistant Klebsiella pneumoniae (CRKP) clinical isolations have rapidly increased in pediatric patients. To investigate a possible health care-associated infections of CRKP in a tertiary pediatric hospital, the circulating clones and carbapenem-resistant pattern between CRKP and carbapenem-resistant Acinetobacter baumannii (CRAB) isolates were compared to classify their epidemiological characteristics. The results will help to identify the epidemic pattern of the CRKP transmission in the hospital.MethodsNinety-six CRKP and forty-eight CRAB isolates were collected in Kunming Children’s Hospital from 2019 through 2022. These isolates were genotyped using repetitive extragenic palindromic-PCR (REP-PCR). Carbapenemase phenotypic and genetic characterization were investigated using a disk diffusion test and singleplex PCR, respectively. In addition, these characteristics of the two pathogens were compared.ResultsThe rates of CRKP and CRAB ranged from 15.8% to 37.0% at the hospital. Forty-nine and sixteen REP genotypes were identified among the 96 and 48 CRKP and CRAB isolates tested, respectively. The CRKP isolates showed more genetic diversity than the CRAB isolates. Of the 96 CRKP isolates, 69 (72%) produced Class B carbapenemases. However, all 48 CRAB isolates produced Class D carbapenemase or extended-spectrum β-lactamases (ESBL) combined with the downregulation of membrane pore proteins. Furthermore, the carbapenemase genes blaKPC, blaIMP, and blaNDM were detected in CRKP isolates. However, CRAB isolates were all positive for the blaVIM, blaOXA-23, and blaOXA-51 genes.ConclusionsThese CRKP isolates exhibited different biological and genetic characteristics with dynamic changes, suggesting widespread communities. Continuous epidemiological surveillance and multicenter research should be carried out to strengthen the prevention and control of infections.</p

Acute psychosocial stress weakens the sense of agency in healthy adults

The sense of agency (SoA) refers to the feeling of being in control of one’s actions and the subsequent consequence of these actions. Emotional context seems to alter the strength of sense of agency. The present study explored the influence of acute psychosocial stress on the SoA by means of the Trier Social Stress Test (TSST). Self-assessment manikin (SAM) and objective physiological indicators (e.g. heart rate, electrodermal activity, and salivary cortisol levels) were utilized to evaluate the effect of the TSST. We also employed the temporal binding effect as an implicit assessment of the participant’s SoA. The results indicated that the stress level of the experimental group after TSST was significantly higher than the control group, whilst the temporal binding scores of the experimental group decreased after TSST manipulation. In short, acute psychosocial stress with intense emotional arousal weakened the sense of agency.</p