Supp Table 2: Revisiting Ediacaran to early Cambrian depositional history of the western North China: Did it remain passive until mid-Paleozoic?

Supplementary Table 2. In-situ Lu-Hf isotope data of detrital zircons with U-Pb ages of c. 1600–500 Ma from Ediacaran and Cambrian sandstones from the western North China Block

Supp Figure 1: Revisiting Ediacaran to early Cambrian depositional history of the western North China: Did it remain passive until mid-Paleozoic?

Appendix Figure 1. Representative photomicrographs (cross-polarized light) for sampled selected for detrital zircon U-Pb analyses. Sample locations are shown in Figure 2. (a) Sample S002 from the Hangqikou Formation at the Huating Section. (b) Sample QLSLQ from the Luoqan Formation at the Qinglongshan Section. (c) Sample YSX-1 from the Luoqan Formation at the Yinshixia Section. (d) Sample QLSHW from the Suyukou Formation at the Qinglongshan Section. (e) Sample YSX-3 from the Suyukou Formation at the Yinshixia Section. (f) Sample SYSX-7 from the Mantou Formation at the Yinshixia Section. Qtz, quartz grain; Kfs, K-feldspar; Lv, Volcanic lithic fragement; Ls, Sedimentary lithic fragment

Supp Table 1: Revisiting Ediacaran to early Cambrian depositional history of the western North China: Did it remain passive until mid-Paleozoic?

Supplementary Table 1. Laser ablation inductively coupled plasma spectrometry (LA-ICP-MS) data for detrital zircons of Statherian and Cambrian sandstones from the western North China Block

Supp Table 2: Revisiting Ediacaran to early Cambrian depositional history of the western North China: Did it remain passive until mid-Paleozoic?

Supplementary Table 2. In-situ Lu-Hf isotope data of detrital zircons with U-Pb ages of c. 1600–500 Ma from Ediacaran and Cambrian sandstones from the western North China Block

Supp Table 1: Revisiting Ediacaran to early Cambrian depositional history of the western North China: Did it remain passive until mid-Paleozoic?

Supplementary Table 1. Laser ablation inductively coupled plasma spectrometry (LA-ICP-MS) data for detrital zircons of Statherian and Cambrian sandstones from the western North China Block

Supp Figure 2: Revisiting Ediacaran to early Cambrian depositional history of the western North China: Did it remain passive until mid-Paleozoic?

Appendix Figure 2. Representative cathodoluminescence images of analyzed zircons from Statherian to Cambrian samples from the western North China Block, with red circles showing analytical spots and yellow and white numbers displaying corresponding U-Pb ages and Th/U ratios, respectively. (a) S002, (b) QLSLQ, (c) YSX-1, (d) QLSHW, (e) YSX-3, (f) SYSX-7

Miocene lamprophyre and felsic volcanics in the outer zone of SW Japan: arc building through multiple sources in an active convergent margin

Subduction-related magmatism is a significant contributor to arc building and continental growth. In the active convergent margin of the SW Japan arc, voluminous volcanic rocks and mafic dykes formed through subduction and back-arc rifting during Miocene. In this study, we investigate a suite of felsic volcanic rocks (rhyolite and dacite) and lamprophyres from central Shikoku Island, which occur in the north-central part of the Chichibu belt and Sanbagawa belt in the Outer zone of the SW Japan arc. Whole-rock geochemistry results show that the rhyolite and dacite samples are peraluminous, belong to the high-K calc-alkaline series, show LREE and LILE enrichment, HREE and HFSE depletion that suggest arc volcanic affinity. The lamprophyre samples belong to alkali lamprophyre, show LREE and HFSE enrichments, and display OIB (oceanic island basalt)-like geochemical features. The 206Pb/238U weighted mean ages of the zircons from the rhyolite and dacite samples range from 14.39 ± 0.21 Ma to 13.92 ± 0.30 Ma, whereas the lamprophyre shows 206Pb/238U weighted mean age of 12.21 ± 0.35 Ma. Zircon Lu-Hf isotope data suggest that the rhyolite and dacite were derived from the remelting of the arc crustal rocks and that the lamprophyre was derived from depleted mantle sources and was contaminated by crustal materials. The felsic volcanic rocks (rhyolite and dacite) can be correlated to Miocene (15.5 Ma to 13.5 Ma) magmatism in the Outer Zone of the SW Japan arc. The formation of lamprophyre dykes in the SW Japan arc may be related to the subhorizontal mantle flows beneath the SW Japan arc associated with the opening of the Japan Sea back-arc basin or asthenosphere upwelling through the slab-tear of the Philippine Sea Plate beneath the SW Japan arc. Our study shows that the SW Japan Arc was built by multiple magmatism from diverse sources in an active convergent margin.</p

Late Triassic magmatic rocks in the southern East Kunlun Orogenic Belt, northern Tibetan Plateau: Petrogenesis and tectonic implications

The East Kunlun Orogenic Belt (E-KOB) documents successive subduction and accretion processes of the Paleo-Tethyan Ocean. However, the tectonic regime of the E-KOB at the late orogenic stage remains ambiguous. This study presents new results of whole-rock geochemistry and zircon U-Pb-Hf isotopes of the Xidatan pluton in the southern E-KOB. Detailed investigation reveals that the pluton is composed of quartz monzodiorite, host monzogranite, and igneous microgranular enclaves (IMEs). Zircon U-Pb dating results suggest that they are coeval magmatic rocks emplaced at ca. 206–203 Ma. Geochemical studies reveal that the quartz monzodiorite and IMEs share a common magma source, evidenced by consistent compositions of major elements, congruently enriched LREEs and LILEs, and consistently moderately depleted HFSEs and HREEs. Enriched to slightly juvenile zircon Hf isotopes (εHf(t) = −4.24 to +0.49) indicate that the primitive magmas of the quartz monzodiorite and IMEs involve the addition of mantle-derived magmas. The quartz monzodiorite and IMEs have identical ages, and consistent isotope features with the host monzogranite, together with the observation of ingestion of xenocrysts from host felsic rocks into the IMEs indicating that they were produced through the mixing of the mantle-derived mafic magmas and host felsic magmas. In contrast, The host monzogranite has moderately high SiO2 and Na2O+K2O, but low Fe2O3T and MgO contents. It shows crust-like trace element patterns such as strong enrichments in LREEs and LILEs, but remarkable depletions in HREEs. Along with enriched zircon Hf isotopes (εHf(t) = −3.51 to −0.25), the host monzogranite was most likely to have originated from partial melting of lower crustal mafic rocks induced by underplated mantle-derived magmas. Considering abundant Late Triassic igneous rocks across the E-KOB, these new data provide further evidence that the Late Triassic magmatism in the E-KOB may be related to the delamination of thickened orogenic root under an extensional setting.</p

A novel frameshift mutation of <i>SMPX</i> causes a rare form of X-linked nonsyndromic hearing loss in a Chinese family

<div><p>X-linked hearing impairment is the rarest form of genetic hearing loss (HL) and represents only a minor fraction of all cases. The aim of this study was to investigate the cause of X-linked inherited sensorineural HL in a four-generation Chinese family. A novel duplication variant (c.217dupA, p.Ile73Asnfs*5) in <i>SMPX</i> was identified by whole-exome sequencing. The frameshift mutation predicted to result in the premature truncation of the SMPX protein was co-segregated with the HL phenotype and was absent in 295 normal controls. Subpopulation screening of the coding exons and flanking introns of <i>SMPX</i> was further performed for 338 Chinese patients with nonsydromic HL by Sanger sequencing, and another two potential causative substitutions (c.238C>A and c.55A>G) in <i>SMPX</i> were identified in additional sporadic cases of congenital deafness. Collectively, this study is the first to report the role of <i>SMPX</i> in Chinese population and identify a novel frameshift mutation in <i>SMPX</i> that causes not only nonsyndromic late-onset progressive HL, but also congenital hearing impairment. Our findings extend the mutation and phenotypic spectrum of the <i>SMPX</i> gene.</p></div

Schematic physical and genetic map of the <i>SMPX</i> gene (NM_014332.2, NP_055147, OMIM: 300066) and three variations found in family LD-101 and two additional sporadic cases.

<p>(A): Schematic physical and genetic maps of <i>SMPX</i>, located in the Xp21.12 chromosomal region (red bar). (B): Structure of the <i>SMPX</i> gene (5 exons) showing five known mutations (above the bar, black) and the identified variations in this study (below the bar, orange and red). (C): Sequencing chromatograms of <i>SMPX</i> showing the missense mutation c. 217dupA in exon 4 in the Chinese family. Electropherograms of a respective heterozygous female carrier (II-1) and two hemizygous male (IV-1 and IV-3) are shown in comparison to a reference sequence. The duplicated nucleotide is indicated by a red box. (D): Two identified variations likely responsible for the hearing loss phenotype in two <i>GJB2</i>-negative individuals (HL053 and M9450). The mutated nucleotide is indicated by red arrows. (E): Conservation analysis shows that Asn19Asp and Leu80Ile are highly conserved across human (Q9UHP9), mouse (Q9DC77), rat (Q925F0), pig (Q0MUU2), bovine (Q3ZBD4) and orangutan (Q5RB90).</p