Enhanced Actuation Strains of Rubber Composites by Combined Covalent and Noncovalent Modification of TiO₂ Nanoparticles

TiO2 nanoparticles were functionalized by combined covalent and noncovalent modification and subsequently used to enhance actuated strains of acrylonitrile–butadiene rubber (NBR) composites. The TiO2 nanoparticles were first modified by noncovalent deposition of poly­(catechol/polyamine) (PCPA) and subsequently functionalized with γ-(2,3-epoxypropoxy)-propytrimethoxysilane (GPTMS) to form TiO2–PCPA–GPTMS nanoparticles. The PCPA deposition preserved the original surface characteristics of the TiO2 nanoparticles, whereas the epoxy groups of GPTMS provided strong interfacial interaction with the polar rubber. The modified TiO2–PCPA–GPTMS nanoparticles enhanced mechanical, dielectric, and electromechanical properties of NBR composites. Thus, the composite filled with 10 phr TiO2–PCPA–GPTMS showed an approximate actuated strain of 11% under an electric filed of 47 kV/mm, which was about 230% of pure NBR in this study (4.8%). Compared with dopamine modification, the method described herein is cheaper and requires shorter reaction times, and it may have potential applications in industry

Table1_Pharmacokinetics, metabolite profiling, safety and tolerability of YZJ-4729 tartrate, a novel G protein-biased μ-opioid receptor agonist, in healthy Chinese subjects.DOCX

Objective: YZJ-4729 is a novel G protein-biased μ-opioid receptor agonist for the treatment of acute pain in adult patients who require intravenous opioid analgesic therapy. The aim of this study was to assess the pharmacokinetics, metabolite profiling, safety and tolerability of YZJ-4729 in healthy Chinese subjects following the single intravenous doses ranged from 0.2 mg to 6 mg.Methods: This single-center, randomized, double-blind, placebo-controlled clinical study was conducted in 54 healthy male and female Chinese subjects after single ascending doses of YZJ-4729 tartrate (0.2, 0.5, 1.5, 3, 4.5, and 6 mg). Subjects in each cohort were assigned randomly to receive a single intravenous dose of YZJ-4729 tartrate injection or placebo at a ratio of 4:1. Pharmacokinetic characteristics, metabolite profiling, safety and tolerability profiles of the study drug were evaluated.Results: Overall, YZJ-4729 was safe and well tolerated in healthy Chinese subjects. The study drug reached peak plasma concentrations nearly at the end of the infusion. After administration, YZJ-4729 was eliminated rapidly with a terminal elimination half-life of 0.862–2.50 h, and excreted little in human excreta. The maximum drug concentration and area under the plasma concentration-time curve increased with dose escalation across the entire dose range. YZJ-4729 experienced extensive metabolism in human body. A total of 19 metabolites were identified and the characteristic metabolic pathways involved hydroxylation, ketone formation, N-dealkylation and glucuronide conjugation. Metabolite M10 was the most abundant circulating metabolite, and represented over 10% of total drug-related systemic exposure. Further PK and safety evaluation of M10 was necessary.Conclusion: The clinical study results laid a foundation for the further clinical studies of YZJ-4729 in patients.Clinical Trial Registration:http://www.chinadrugtrials.org.cn, identifier CTR20222574.</p

Self-Healing and Elastic Triboelectric Nanogenerators for Muscle Motion Monitoring and Photothermal Treatment

Owing to wearing and unpredictable damage, the working lifetime of triboelectric nanogenerators (TENGs) is largely limited. In this work, we prepared a single-electrode multifunctional TENG (MF-TENG) that exhibits fast self-healing, human health monitoring capability, and photothermal properties. The device consists of a thin self-healing poly­(vinyl alcohol)-based hydrogel sandwiched between two self-healing silicone elastomer films. The MF-TENG exhibits a short-circuit current, short-circuit transfer charge, and open-circuit voltage of 7.98 μA, 78.34 nC, and 38.57 V, respectively. Furthermore, owing to the repairable networks of the dynamic imine bonds in the charged layer and the borate ester bonds in the electrodes, the prepared device could recover its original state after mechanical damage within 10 min at room temperature. The MF-TENG can be attached to different human joints for self-powered monitoring of personal health information. Additionally, the MF-TENG under near-infrared laser irradiation can provide a photothermal therapy for assisting the recovery of human joints motion. It is envisaged that the proposed MF-TENG can be applied to the fields of wearable electronics and health-monitoring devices

Self-Healing and Elastic Triboelectric Nanogenerators for Muscle Motion Monitoring and Photothermal Treatment

Owing to wearing and unpredictable damage, the working lifetime of triboelectric nanogenerators (TENGs) is largely limited. In this work, we prepared a single-electrode multifunctional TENG (MF-TENG) that exhibits fast self-healing, human health monitoring capability, and photothermal properties. The device consists of a thin self-healing poly­(vinyl alcohol)-based hydrogel sandwiched between two self-healing silicone elastomer films. The MF-TENG exhibits a short-circuit current, short-circuit transfer charge, and open-circuit voltage of 7.98 μA, 78.34 nC, and 38.57 V, respectively. Furthermore, owing to the repairable networks of the dynamic imine bonds in the charged layer and the borate ester bonds in the electrodes, the prepared device could recover its original state after mechanical damage within 10 min at room temperature. The MF-TENG can be attached to different human joints for self-powered monitoring of personal health information. Additionally, the MF-TENG under near-infrared laser irradiation can provide a photothermal therapy for assisting the recovery of human joints motion. It is envisaged that the proposed MF-TENG can be applied to the fields of wearable electronics and health-monitoring devices

Datasheet1_Clinical efficacy of PD-1 inhibitor combined with radiotherapy in a multi-drug resistant patient with liver metastasis from gastric cancer.docx

A 54-year-old male was diagnosed with extensive liver metastasis and small nodule metastasis in the lungs from gastric adenocarcinoma [Her-2 (−)]. The patient achieved significant partial response (PR) after chemotherapy combined with anti-angiogenesis therapy but developed progressive disease (PD) after 5 months. Then, the chemotherapeutic and anti-angiogenic drugs were replaced. Meanwhile, the delivery route of some chemotherapeutic drugs was changed, and some chemotherapeutic drugs were given via transcatheter arterial chemoembolization (TACE) to achieve PR, and PD developed after 3 months of remission maintenance. During chemotherapy combined with anti-angiogenesis, the application of programmed cell death-1 (PD-1) inhibitor achieved PR again and maintained for 5 months before disease progression. The progression of the lesions in the left lobe of the liver and the hepatic hilar lymph nodes was significant. Hence, chemotherapy was terminated and gamma stereotactic body radiation therapy (SBRT) was performed on left lobe lesions and hilar lymph nodes. The lesions both inside and outside the radiation field regressed significantly, reaching PR and abscopal effects. The immune-related adverse events (irAEs) occurred, including erythema and black and luster hair. The abscopal effects of lesion reduction in the radiation field and the enhancement of the immune function stimulated by radiation are a highlight of the combination of radiation and immunotherapy. In the end, the patient died of gastrointestinal failure, with overall survival of 18 months.</p

Self-Healing and Elastic Triboelectric Nanogenerators for Muscle Motion Monitoring and Photothermal Treatment

Owing to wearing and unpredictable damage, the working lifetime of triboelectric nanogenerators (TENGs) is largely limited. In this work, we prepared a single-electrode multifunctional TENG (MF-TENG) that exhibits fast self-healing, human health monitoring capability, and photothermal properties. The device consists of a thin self-healing poly­(vinyl alcohol)-based hydrogel sandwiched between two self-healing silicone elastomer films. The MF-TENG exhibits a short-circuit current, short-circuit transfer charge, and open-circuit voltage of 7.98 μA, 78.34 nC, and 38.57 V, respectively. Furthermore, owing to the repairable networks of the dynamic imine bonds in the charged layer and the borate ester bonds in the electrodes, the prepared device could recover its original state after mechanical damage within 10 min at room temperature. The MF-TENG can be attached to different human joints for self-powered monitoring of personal health information. Additionally, the MF-TENG under near-infrared laser irradiation can provide a photothermal therapy for assisting the recovery of human joints motion. It is envisaged that the proposed MF-TENG can be applied to the fields of wearable electronics and health-monitoring devices

Self-Healing and Elastic Triboelectric Nanogenerators for Muscle Motion Monitoring and Photothermal Treatment

Owing to wearing and unpredictable damage, the working lifetime of triboelectric nanogenerators (TENGs) is largely limited. In this work, we prepared a single-electrode multifunctional TENG (MF-TENG) that exhibits fast self-healing, human health monitoring capability, and photothermal properties. The device consists of a thin self-healing poly­(vinyl alcohol)-based hydrogel sandwiched between two self-healing silicone elastomer films. The MF-TENG exhibits a short-circuit current, short-circuit transfer charge, and open-circuit voltage of 7.98 μA, 78.34 nC, and 38.57 V, respectively. Furthermore, owing to the repairable networks of the dynamic imine bonds in the charged layer and the borate ester bonds in the electrodes, the prepared device could recover its original state after mechanical damage within 10 min at room temperature. The MF-TENG can be attached to different human joints for self-powered monitoring of personal health information. Additionally, the MF-TENG under near-infrared laser irradiation can provide a photothermal therapy for assisting the recovery of human joints motion. It is envisaged that the proposed MF-TENG can be applied to the fields of wearable electronics and health-monitoring devices

Pure-Phase, Large-Grained Wide-Band-Gap Perovskite Films for High-Efficiency, Four-Terminal Perovskite/Silicon Tandem Solar Cells

High-quality, stable perovskite films with a wide band gap between 1.65 and 1.80 eV are highly suitable for efficient and cost-competitive silicon-based tandem solar cells. Herein, we demonstrate that the combined strategies of the Pb(SCN)2 additive and air annealing can enable the Cs0.22FA0.78Pb(I0.85Br0.15)3 films with a wide band gap of 1.65 eV and favored properties including pure composition, high crystallinity, micro-sized grains, and reduced defects. With these desired films, the average efficiencies of semitransparent perovskite solar cells (PSCs) are boosted from (18.13 ± 0.31) to (20.35 ± 0.28)%. Further, the semitransparent PSC is used to assemble the four-terminal perovskite/TOPCon tandem solar cell. Benefiting from its excellent performance and preferred optical properties, the obtained tandem solar cell yields a milestone efficiency of 30.32%