Sensitivity analyses: Effect of different research characteristics on POCD or POD with ApoE4 carriers.

Sensitivity analyses: Effect of different research characteristics on POCD or POD with ApoE4 carriers.</p

Trial sequential analysis of the incidence of POCD or POD^a.

Trial sequential analysis of the incidence of POCD or PODa.</p

Sensitivity analyses: Effect of different research characteristics on POCD or POD with ApoE4 carriers.

Sensitivity analyses: Effect of different research characteristics on POCD or POD with ApoE4 carriers.</p

Details of thirty-three full-text studies excluded.

Details of thirty-three full-text studies excluded.</p

Characteristics of included studies.

The aim of systematic review and meta-analysis was to investigate whether APOE4 was associated with postoperative neurologic dysfunction occurrence in short- or medium-term among surgical patients and to study the potential genetic association among these two entities. We searched electronic databases for reserch studies to evaluate the association of APOE4 with postoperative delirium (POD) or short- and medium term postoperative cognitive dysfunction (POCD). Twenty-two trials (16 prospective and six retrospective) with 6734 patients were included. APOE4 alleles was shown significantly associated with POCD within 1 week (odds ratio, OR, 1.89, 95% confidence interval, CI, 1.36 to 2.6278, p </div

Search strategy for all electronic databases.

The aim of systematic review and meta-analysis was to investigate whether APOE4 was associated with postoperative neurologic dysfunction occurrence in short- or medium-term among surgical patients and to study the potential genetic association among these two entities. We searched electronic databases for reserch studies to evaluate the association of APOE4 with postoperative delirium (POD) or short- and medium term postoperative cognitive dysfunction (POCD). Twenty-two trials (16 prospective and six retrospective) with 6734 patients were included. APOE4 alleles was shown significantly associated with POCD within 1 week (odds ratio, OR, 1.89, 95% confidence interval, CI, 1.36 to 2.6278, p </div

A forest plot showing a comparison of intracuff lidocaine (alkalinized and non-alkalinized) used and the control groups, as well as the incidence of POST at 24 h.

<p>A forest plot showing a comparison of intracuff lidocaine (alkalinized and non-alkalinized) used and the control groups, as well as the incidence of POST at 24 h.</p

A flowchart showing the selection of the randomized controlled trials for our meta-analysis.

<p>A flowchart showing the selection of the randomized controlled trials for our meta-analysis.</p

Flow diagram showing study selection process.

The aim of systematic review and meta-analysis was to investigate whether APOE4 was associated with postoperative neurologic dysfunction occurrence in short- or medium-term among surgical patients and to study the potential genetic association among these two entities. We searched electronic databases for reserch studies to evaluate the association of APOE4 with postoperative delirium (POD) or short- and medium term postoperative cognitive dysfunction (POCD). Twenty-two trials (16 prospective and six retrospective) with 6734 patients were included. APOE4 alleles was shown significantly associated with POCD within 1 week (odds ratio, OR, 1.89, 95% confidence interval, CI, 1.36 to 2.6278, p </div

The effect of intracuff lidocaine (alkalinized and non-alkalinized) used on the POST pain score at 1 h.

<p>The effect of intracuff lidocaine (alkalinized and non-alkalinized) used on the POST pain score at 1 h.</p