V1 responses to spatially uniform colors.

<p><b>A</b>, A conventional activation map in response to a red stimulus. <b>B–D</b>, The SVM-derived activation maps in response to red, green, and blue stimuli, respectively. <b>E</b>, The SVM-derived activation map from trials without color stimulation (gray screen). <b>F</b>, The patches responding significantly to the majority of the tested colors. Scale bar, 0.5 mm.</p

Identification of response patches in V1.

<p>The first column from the left shows a part of the activation maps associated with different stimulus colors. The three vertical dots stand for six more maps that are not shown due to space limitation. A threshold derived from the control map was used to identify the individual response regions in each activation map. These response regions are shown as the white patches in the second column from the left. The individual response regions elicited by various stimuli were combined to form the composite response patches, as shown in the third column from the left. The rightmost column shows the kind of composite response patches that were analyzed in the current study. Each of these patches meets both of the following criteria: 1) it encompasses individual response regions that are associated with five or more stimulus colors; 2) it doesn't extend to the map borders.</p

Two-way clustering of V1 responses to color.

<p><b>A–B</b>, I_pn as a function of R_LM and R_Y, respectively, averaged across all response patches. The sign of I_pn indicates the cluster that a response was assigned to, and the value indicates the consistency of the assignment across the response patches. <b>C</b>, The distribution of response patches with different number of outliers (N_d) according to the R_LM-based clustering (black) or R_Y-based clustering (striped).</p

Visual stimuli and temporal order of experiments.

<p><b>A</b>, CIE 1931-xy coordinates of the stimulus colors. R, red; O, Orange; Y, Yellow; L, Lime; G, green; A, aqua; B, blue; P, purple; K, pink; W, gray. <b>B</b>: Temporal sequence of stimulus presentation and data acquisition. Each tick mark indicates the time at which a cortical image was acquired. Adapted from ref <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0024994#pone.0024994-Xiao1" target="_blank">[18]</a> with permission.</p

Two-way categorization and cone contrasts of the color chips used in the World Color Survey (WCS).

<p><b>A–B</b>, I_wc as a function of R_LM and R_Y respectively. The sign of I_wc indicates the category that a chip was assigned to. The value of I_wc reflects the consistency of the categorization across the WCS database. R_LM and R_Y denote the L−M and (L+M)-S cone contrast, respectively. <b>C</b>, Scatter plot of R_LM<i>versus</i> R_Y. The chips in different categories are represented by symbols of different colors (red <i>vs</i>. black).</p

Clinical characteristics of patients.

<p><i>Abbreviations</i>: WHO = World Health Organization; RT =  radiotherapy; ICT =  Induction chemotherapy.</p><p>CCRT =  concurrent chemoradiotherapy, ACT = adjuvant chemotherapy.</p

Survival rate by T-category in 375 patients: (A) local relapse-free survival, (B) distant metastasis-free survival, and (C) overall survival.

<p>Group A: T3 without MRI-detected cranial nerve involvement; Group B: T3 with MRI-detected cranial nerve involvement.</p

72-year-old man with nasopharyngeal carcinoma with cranial nerve invasion: (A) enhanced axial T1-weighted image with fat suppression shows the effacement of the left gasserian ganglion (short arrow); (B) axial PD weighted imaging shows the normal right gasserian ganglion (long arrow).

<p>72-year-old man with nasopharyngeal carcinoma with cranial nerve invasion: (A) enhanced axial T1-weighted image with fat suppression shows the effacement of the left gasserian ganglion (short arrow); (B) axial PD weighted imaging shows the normal right gasserian ganglion (long arrow).</p

39-year-old woman with nasopharyngeal carcinoma with cranial nerve invasion: (A) enhanced coronal T1-weighted image with fat suppression shows the enlarged left foramen ovale with abnormal enhancement (short arrow); (B) the enhanced axial T1-weighted image with fat suppression shows the enlargement and abnormal enhancement of cranial nerve V3 (long arrow).

<p>39-year-old woman with nasopharyngeal carcinoma with cranial nerve invasion: (A) enhanced coronal T1-weighted image with fat suppression shows the enlarged left foramen ovale with abnormal enhancement (short arrow); (B) the enhanced axial T1-weighted image with fat suppression shows the enlargement and abnormal enhancement of cranial nerve V3 (long arrow).</p

Incidence and survival in patients with and without MRI-detected CNI.

<p>Abbreviations: MRI  =  magnetic resonance imaging; CNI  =  cranial nerve involvement; LRFS  =  local relapse-free survival; DMFS  =  distant metastasis-free survival; OS =  overall survival.</p><p>*P Value was calculated using Cox proportional hazards model after adjusted for T and N classification.</p