Novel a‐Si:H TFT pixel circuit for electrically stable top‐anode light‐emitting AMOLEDs

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/92120/1/1.2770853.pd

Evaluation formulas for a conditional Feynman integral over Wiener paths in abstract Wiener space

summary:In this paper, we introduce a simple formula for conditional Wiener integrals over $C_0(\mathbb{B})$, the space of abstract Wiener space valued continuous functions. Using this formula, we establish various formulas for a conditional Wiener integral and a conditional Feynman integral of functionals on $C_0(\mathbb{B})$ in certain classes which correspond to the classes of functionals on the classical Wiener space introduced by Cameron and Storvick. We also evaluate the conditional Wiener integral and conditional Feynman integral for functionals of the form $$\exp \biggl \lbrace \int _0^T \theta (s, x(s))\mathrm{d}\eta (s) \biggr \rbrace$$ which are of interest in Feynman integration theories and quantum mechanics

Speech Processing Research Program

Contains an introduction and reports on five research projects.National Science Foundation FellowshipNational Science Foundation Grant MIP 87-14969U.S. Navy - Office of Naval Research Contract N00014-89-J-1489U.S. Air Force - Electronic Systems Division Contract F19628-89-K-0041National Science Foundation Fellowshi

Toxicological Study on MUNOPHIL, Water Extract of Panax ginseng and Hericium erinaceum in Rats

AbstractObjectiveAs data on the safety profile of Panax ginseng and Hericium erinaceum is lacking, the safety of these two compounds was examined in a series of toxicological studies.Materials and MethodsMUNOPHIL, the water extract mixture of Panax ginseng and Hericium erinaceum was tested in an oral subchronic 28-day toxicity study in rats at doses of 1250, 2500 and 5000 mg/kg/day.ResultsIn repeated dose toxicity studies, no mortality was observed when varying doses of the extracts were administered once daily for a period of 28 days. There were no significant differences in body weight, absolute and relative organ weights between controls and treated rats of both sexes. Hematological analysis showed no differences in most parameters examined. In the biochemistry parameter analysis, no significant change occurred. Pathologically, neither gross abnormalities nor his-topathological changes were observed. Therefore, MUNOPHIL appears to be safe and non-toxic in these studies and a no-observed adverse effect level in rats was established at 5000 mg/kg/day.ConclusionThe data could provide satisfactory preclinical evidence of safety to launch clinical trials on standardized formulation of plant extracts

Cell type–dependent variation in paracrine potency determines therapeutic efficacy against neonatal hyperoxic lung injury

AbstractBackground aimsThe aim of this study was to determine the optimal cell type for transplantation to protect against neonatal hyperoxic lung injury. To this end, the in vitro and in vivo therapeutic efficacies and paracrine potencies of human umbilical cord blood–derived mesenchymal stromal cells (HUMs), human adipose tissue–derived mesenchymal stromal cells (HAMs) and human umbilical cord blood mononuclear cells (HMNs) were compared.MethodsHyperoxic injury was induced in vitro in A549 cells by challenge with H2O2. Alternatively, hyperoxic injury was induced in newborn Sprague-Dawley rats in vivo by exposure to hyperoxia (90% oxygen) for 14 days. HUMs, HAMs or HMNs (5 × 105 cells) were given intratracheally at postnatal day 5.ResultsHyperoxia-induced increases in in vitro cell death and in vivo impaired alveolarization were significantly attenuated in both the HUM and HAM groups but not in the HMN group. Hyperoxia impaired angiogenesis, increased the cell death and pulmonary macrophages and elevated inflammatory cytokine levels. These effects were significantly decreased in the HUM group but not in the HAM or HMN groups. The levels of human vascular endothelial growth factor and hepatocyte growth factor produced by donor cells were highest in HUM group, followed by HAM group and then HMN group.ConclusionsHUMs exhibited the best therapeutic efficacy and paracrine potency than HAMs or HMNs in protecting against neonatal hyperoxic lung injury. These cell type-dependent variations in therapeutic efficacy might be associated or mediated with the paracrine potency of the transplanted donor cells

Advanced Telecommunications and Signal Processing Program

Contains an introduction, and reports on seven research projects.Advanced Telecommunications Research ProgramAT&T FellowshipINTEL FellowshipU.S. Navy - Office of Naval Research NDSEG Graduate FellowshipMaryland Procurement Office Contract MDA904-93-C-418

Detection Probability of a Low-Mass Planet for Triple Lens Events: Implication of Properties of Binary-Lens Superposition

In view of the assumption that any planetary system is likely to be composed of more than one planet, and the multiple planet system with a large mass planet has more chance of detailed follow-up observations, the multiple planet system may be an efficient way to search for sub-Jovian planets. We compare the magnification pattern of the triple lens system with that of a best-fitted binary system composed of a star and a Jovian mass planet, and check the probability in detecting the low-mass secondary planet whose signature will be superposed on that of the primary Jovian mass planet. Detection probabilities of the low-mass planet in the triple lens system are quite similar to the probability in detecting such a low-mass planet in a binary system with a star and only a low-mass planet, which shows that the signature of a low-mass planet can be effectively detected even when it is concurrent with the signature of the more massive planet, implying that the binary superposition approximation works over a relatively broad range of planet mass ratio and separations, and the inaccuracies thereof do not significantly affect the detection probability of the lower mass secondary planet. Since the signature of the Jovian mass planet will be larger and lasts longer, thereby warranting more intensive follow-up observations, the actual detection rate of the low-mass planet in a triple system with a Jovian mass can be significantly higher than that in a binary system with a low-mass planet only. We conclude that it may be worthwhile to develop an efficient algorithm to search for `super-Earth' planets in the paradigm of the triple lens model for high-magnification microlensing events.Comment: 10 pages, 5 figures, accepted by MNRA

The Importance of Binary Gravitational Microlensing Events Through High-Magnification Channel

We estimate the detection efficiency of binary gravitational lensing events through the channel of high-magnification events. From this estimation, we find that binaries in the separations ranges of 0.1 < s < 10, 0.2 < s < 5, and 0.3 < s < 3 can be detected with ~ 100% efficiency for events with magnifications higher than A=100, 50, and 10, respectively, where s represents the projected separation between the lens components normalized by the Einstein radius. We also find that the range of high efficiency covers nearly the whole mass-ratio range of stellar companions. Due to the high efficiency in wide ranges of parameter space, we point out that majority of binary-lens events will be detected through the high-magnification channel in lensing surveys that focus on high-magnification events for efficient detections of microlensing planets. In addition to the high efficiency, the simplicity of the efficiency estimation makes the sample of these binaries useful in the statistical studies of the distributions of binary companions as functions of mass ratio and separation. We also discuss other importance of these events.Comment: 5 pages, 1 figure, 1 tabl

Early prediction of molecular remission by monitoring BCR-ABL transcript levels in patients achieving a complete cytogenetic response after imatinib therapy for posttransplantation chronic myelogenous leukemia relapse

Imatinib induces a high complete cytogenetic response (CCR) rate in relapsed chronic myelogenous leukemia. By analyzing minimal residual disease (MRD) under the levels of CCR, we tried to assess the molecular response after imatinib therapy. By using real-time quantitative reverse transcriptase-polymerase chain reaction (Q-RT-PCR), MRD was evaluated in 23 patients (3 in cytogenetic relapse, 6 in chronic phase, 9 in accelerated phase, and 5 in blast crisis) who were treated with standard-dose imatinib for relapsed chronic myelogenous leukemia after allogeneic stem cell transplantation. With a median therapy time of 399 days (range, 35–817 days), 19 (83%) patients achieved a CCR. Meanwhile, 11 (58%) of them achieved a molecular remission (MR), which was associated with improved survival. The Q-RT-PCR data were compared according to the best response (MR, n = 11; CCR, n = 8) in the patients achieving a CCR. The BCR-ABL/ABL ratios were similar in 2 groups at 3 months but were significantly different at 6 months (median, 0.0000012 for MR and 0.00022 for CCR; P = .003). The probability of a subsequent MR was significantly higher in patients with a lower BCR-ABL/ABL ratio at 6 months (100% for <0.0001 versus 33% for ≥0.0001; P = .006) or a greater reduction in the level between 3 and 6 months (log-reduction ≥1.0;, 100%; <1.0, 17%; P = .003). Q-RT-PCR is a reliable method for monitoring MRD: the early trends in the BCR-ABL/ABL ratio may be clinically useful in discriminating patients who will achieve an MR from those who will remain in CCR

Advanced Telecommunications and Signal Processing Program

Contains an introduction and reports on eleven research projects.Advanced Telecommunications Research Progra