Photoalkylation/-arylation of <i>ortho</i>-Diketones with Unactivated Organic Halides

A new method for conducting a reductive alkylation/arylation of 1,2-diketones using visible light and unactivated organic halides is presented in this article. This technique does not require a photocatalyst and employs Et3N, a tertiary amine, as a promoter. This amine aids in generating a ketyl radical and an α-aminoalkyl radical, which engages in a C–X bond activation via a halogen atom transfer process (XAT). This approach’s success hinges on utilizing Et3N as the promoter. This article’s mild and straightforward protocol allows for significantly expanding organic halide substrates, including primary, secondary, and aromatic organic halides and various functional groups

Oxidative Recyclization of 1<i>H</i>‑Indoles for Synthesis of 2‑Indolylbenzoxazinones via Cleavage of the C2–C3 Bond with AIBN under Air

A novel and concise method for the oxidation of unprotected indole derivatives to synthesize 2-indolylbenzoxazinones in the presence of AIBN under open air has been successfully demonstrated. This metal-free reaction is both atom- and step-efficient and is applicable to a broad scope of substrates. This new methodology provides a facile pathway for oxidative C2–C3 bond cleavage and recyclization of 1<i>H</i>-indoles