Homochiral Silver-Based Coordination Polymers Exhibiting Temperature-Dependent Photoluminescence Behavior

Homochiral coordination polymers based on zigzag or helical polymers are assembled from a semiflexible fluorescent bipyridyl ligand and linear coordinated Ag^I ions; they exhibit unusual temperature-dependent photoluminescence behavior, including multistep changes in energy and intensity upon cooling

Homochiral Silver-Based Coordination Polymers Exhibiting Temperature-Dependent Photoluminescence Behavior

Homochiral coordination polymers based on zigzag or helical polymers are assembled from a semiflexible fluorescent bipyridyl ligand and linear coordinated Ag^I ions; they exhibit unusual temperature-dependent photoluminescence behavior, including multistep changes in energy and intensity upon cooling

Porous and Robust Lanthanide Metal-Organoboron Frameworks as Water Tolerant Lewis Acid Catalysts

Porous and robust 12-connected metal–organic frameworks (MOFs) were constructed by linking tetranuclear lanthanide (Ln) carbonate clusters with organoboron-derived tricarboxylate bridging ligands. The high-connectivity Ln-MOFs feature remarkable thermal and hydrolytic stability and a large number of isolated Lewis acid B­(III) and Ln­(III) sites on the pore surfaces. The Nd-MOF assisted with sodium dodecylsulfate was found to be highly effective, recyclable, and reusable heterogeneous catalyst for the carbonyl allylation reaction, the Diels–Alder reaction, and the Strecker-type reaction in water. The transformations were cocatalyzed by Nd­(III) and B­(III) Lewis acids, with activities much higher than those of the individual organoboron and lanthanide counterparts and their mixture. This work highlights the potential of generating highly efficient water-tolerant solid catalysts via heterogenization of different weak and/or mild Lewis acids in confined spaces of robust MOFs

Porous and Robust Lanthanide Metal-Organoboron Frameworks as Water Tolerant Lewis Acid Catalysts

Porous and robust 12-connected metal–organic frameworks (MOFs) were constructed by linking tetranuclear lanthanide (Ln) carbonate clusters with organoboron-derived tricarboxylate bridging ligands. The high-connectivity Ln-MOFs feature remarkable thermal and hydrolytic stability and a large number of isolated Lewis acid B­(III) and Ln­(III) sites on the pore surfaces. The Nd-MOF assisted with sodium dodecylsulfate was found to be highly effective, recyclable, and reusable heterogeneous catalyst for the carbonyl allylation reaction, the Diels–Alder reaction, and the Strecker-type reaction in water. The transformations were cocatalyzed by Nd­(III) and B­(III) Lewis acids, with activities much higher than those of the individual organoboron and lanthanide counterparts and their mixture. This work highlights the potential of generating highly efficient water-tolerant solid catalysts via heterogenization of different weak and/or mild Lewis acids in confined spaces of robust MOFs

A Homochiral Metal–Organic Framework as an Effective Asymmetric Catalyst for Cyanohydrin Synthesis

A homochiral metal–organic framework (MOF) of an enantiopure 2,2′-dihydroxy-1,1′-biphenyl ligand was constructed. After exchanging one proton of the dihydroxyl group for Li­(I) ions, the framework is shown to be a highly efficient and recyclable heterogeneous catalyst for asymmetric cyanation of aldehydes with up to >99% ee. Compared with the homogeneous counterpart, the MOF catalyst exhibits significantly enhanced catalytic activity and enantioselectivity, especially at a low catalyst/substrate ratio, due to that the rigid framework could stabilize the catalytically active monolithium salt of biphenol against its free transformation to catalytically inactive and/or less active assemblies in reactions. The synthetic utility of the cyanation was demonstrated in the synthesis of (<i>S</i>)-bufuralol (a nonselective β-adrenoceptor blocking agent) with 98% ee

Image_1_Case report: Temozolomide induced hypermutation: an indicator associated with immunotherapy response in patient with gliomas.jpeg

BackgroundTemozolomide (TMZ) is a key component in the treatment of gliomas. Hypermutation induced by TMZ can be encountered in routine clinical practice, and its significance is progressively gaining recognition. However, the relationship between TMZ-induced hypermutation and the immunologic response remains controversial.Case presentationWe present the case of a 38-year-old male patient who underwent five surgeries for glioma. Initially diagnosed with IDH-mutant astrocytoma (WHO grade 2) during the first two surgeries, the disease progressed to grade 4 in subsequent interventions. Prior to the fourth surgery, the patient received 3 cycles of standard TMZ chemotherapy and 9 cycles of dose-dense TMZ regimens. Genomic and immunologic analyses of the tumor tissue obtained during the fourth surgery revealed a relatively favorable immune microenvironment, as indicated by an immunophenoscore of 5, suggesting potential benefits from immunotherapy. Consequently, the patient underwent low-dose irradiation combined with immunoadjuvant treatment. After completing 4 cycles of immunotherapy, the tumor significantly shrank, resulting in a partial response. However, after a 6-month duration of response, the patient experienced disease progression. Subsequent analysis of the tumor tissue obtained during the fifth surgery revealed the occurrence of hypermutation, with mutation signature analysis attributing TMZ treatment as the primary cause. Unfortunately, the patient succumbed shortly thereafter, with a survival period of 126 months.ConclusionPatients subjected to a prolonged regimen of TMZ treatment may exhibit heightened vulnerability to hypermutation. This hypermutation induced by TMZ holds the potential to function as an indicator associated with unfavorable response to immunotherapy in gliomas.</p

Table_1_Case report: Temozolomide induced hypermutation: an indicator associated with immunotherapy response in patient with gliomas.docx

BackgroundTemozolomide (TMZ) is a key component in the treatment of gliomas. Hypermutation induced by TMZ can be encountered in routine clinical practice, and its significance is progressively gaining recognition. However, the relationship between TMZ-induced hypermutation and the immunologic response remains controversial.Case presentationWe present the case of a 38-year-old male patient who underwent five surgeries for glioma. Initially diagnosed with IDH-mutant astrocytoma (WHO grade 2) during the first two surgeries, the disease progressed to grade 4 in subsequent interventions. Prior to the fourth surgery, the patient received 3 cycles of standard TMZ chemotherapy and 9 cycles of dose-dense TMZ regimens. Genomic and immunologic analyses of the tumor tissue obtained during the fourth surgery revealed a relatively favorable immune microenvironment, as indicated by an immunophenoscore of 5, suggesting potential benefits from immunotherapy. Consequently, the patient underwent low-dose irradiation combined with immunoadjuvant treatment. After completing 4 cycles of immunotherapy, the tumor significantly shrank, resulting in a partial response. However, after a 6-month duration of response, the patient experienced disease progression. Subsequent analysis of the tumor tissue obtained during the fifth surgery revealed the occurrence of hypermutation, with mutation signature analysis attributing TMZ treatment as the primary cause. Unfortunately, the patient succumbed shortly thereafter, with a survival period of 126 months.ConclusionPatients subjected to a prolonged regimen of TMZ treatment may exhibit heightened vulnerability to hypermutation. This hypermutation induced by TMZ holds the potential to function as an indicator associated with unfavorable response to immunotherapy in gliomas.</p

A Novel and Versatile Strategy to Prepare Metal–Organic Molecular Precursor Solutions and Its Application in Cu(In,Ga)(S,Se)₂ Solar Cells

A novel and versatile metal–organic molecular precursor-based solution approach and the fabrication of high efficiency Cu­(In,Ga)­(S,Se)₂ solar cells are presented. Many types of metal oxides, hydroxides, and acetylacetonates (acac), such as Cu₂O, ZnO, SnO, Sb₂O₃, MnO, PbO, In­(OH)₃, Cd­(OH)₂, Ga­(acac)₃, and so forth, can be easily dissolved in butyldithiocarbamic acid, forming thermally degradable metal–organic molecular precursor solutions. By developing a simple and green ethanol solution-processed route and tuning the chemical composition of the Cu­(In,Ga)­(S,Se)₂ thin film, as-fabricated solar cells exhibit an average power conversion efficiency up to 8.8%

Chiral Metal–Organic Framework Decorated with TEMPO Radicals for Sequential Oxidation/Asymmetric Cyanation Catalysis

A chiral porous metal–organic framework (MOF) decorated with radicals has been successfully constructed by cocrystallizing achiral (2,2,6,6-tetramethylpiperidin-1-yl)­oxyl (TEMPO)-substituted tricarboxylate and enantiopure VO­(salen)-derived dipyridine ligands. The chiral MOF can function as an efficient heterogeneous catalyst for the sequential alcohol oxidation/asymmetric cyanation of aldehyde reactions with enhanced activity and enantioselectivity compared to the homogeneous counterpart