8 research outputs found

    Estimated continuous annual BCSM rates and hazard ratio of BCSM in certain subpopulations.

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    <p>(A) Patients were age<40 with ER negative and node positive diseases. (B) Patients were age≥60 with ER positive and node negative diseases.</p

    Filtration process.

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    <p>We identified 228209 female patients (20 and 84 yrs) diagnosed stages I to III unilateral invasive breast cancer between January 1, 1990, and December 31, 2005, through Surveillance, Epidemiology, and End Results (SEER) Program (<a href="http://www.seer.cancer.gov/" target="_blank">www.seer.cancer.gov</a>) SEER*Stat Database: Incidence—SEER 18 Regs Research Data released April 2015, based on the November 2014 submission.</p

    Annual BCSM rates and hazard ratio of BCSM in the total population and different subgroups.

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    <p>Annual BCSM rates and hazard ratio of BCSM in the total population and different subgroups.</p

    Fully Packaged Carbon Nanotube Supercapacitors by Direct Ink Writing on Flexible Substrates

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    The ability to print fully packaged integrated energy storage components (e.g., supercapacitors) is of critical importance for practical applications of printed electronics. Due to the limited variety of printable materials, most studies on printed supercapacitors focus on printing the electrode materials but rarely the full-packaged cell. This work presents for the first time the printing of a fully packaged single-wall carbon nanotube-based supercapacitor with direct ink writing (DIW) technology. Enabled by the developed ink formula, DIW setup, and cell architecture, the whole printing process is mask free, transfer free, and alignment free with precise and repeatable control on the spatial distribution of all constituent materials. Studies on cell design show that a wider electrode pattern and narrower gap distance between electrodes lead to higher specific capacitance. The as-printed fully packaged supercapacitors have energy and power performances that are among the best in recently reported planar carbon-based supercapacitors that are only partially printed or nonprinted

    Two-Photon Polymerization of Butterfly Wing Scale Inspired Surfaces with Anisotropic Wettability

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    Wings of Morph aega butterflies are natural surfaces that exhibit anisotropic liquid wettability. The direction-dependent arrangement of the wing scales creates orientation-turnable microstructures with two distinct contact modes for liquid droplets. Enabled by recent developments in additive manufacturing, such natural surface designs coupled with hydrophobicity play a crucial role in applications such as self-cleaning, anti-icing, and fluidic manipulation. However, the interplay among resolution, architecture, and performance of bioinspired structures is barely achieved. Herein, inspired by the wing scales of the Morpho aega butterfly, full-scale synthetic surfaces with anisotropic wettability fabricated by two-photon polymerization are reported. The quality of the artificial butterfly scale is improved by optimizing the laser scanning strategy and the objective lens movement path. The corresponding contact angles of water on the fabricated architecture with various design parameters are measured, and the anisotropic fluidic wettability is investigated. Results demonstrate that tuning the geometrical parameters and spatial arrangement of the artificial wing scales enables anisotropic behaviors of the droplet’s motion. The measured results also indicate a reverse phenomenon of the fabricated surfaces in contrast to their natural counterparts, possibly attributed to the significant difference in equilibrium wettability between the fabricated microstructures and the natural Morpho aega surface. These findings are utilized to design next-generation fluid-controllable interfaces for manipulating liquid mobility on synthetic surfaces

    Fabrication, Rheological, and Compositional Characterization of Thermoresponsive Hydrogel from Cornea

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    Fabricating thermoresponsive hydrogels from decellularized tissues is a trending and promising approach to develop novel biomaterials for tissue engineering and therapeutic purposes. There are differences in the characteristics of the produced hydrogels related to the source tissue as well as the decellularization and solubilization protocols used. Detailed characterization of the hydrogels will support the efforts to optimize their application as biomaterials for tissue engineering and therapeutics. Here, we describe an optimized method for fabricating an in situ thermoresponsive hydrogel from decellularized porcine cornea extracellular matrix (COMatrix), and provide a detailed characterization of its structure, thermoresponsive rheological behavior (heat-induced sol-gel transition), as well as exploring its protein composition using proteomics. COMatrix forms a transparent gel (10-min time to gelation) after in situ curing with heat, characterized by alteration in light absorbance and rheological indexes. The rheological characterization of heat-formed COMatrix gel shows similar behavior to common biomaterials utilized in tissue engineering. The fibrillar structure of COMatrix gel was observed by scanning electron microscopy showing that the density of fibers attenuates in lower concentrations. Mass spectrometry-based proteomic analysis revealed that COMatrix hydrogel is rich in proteins with known regenerative properties such as lumican, keratocan, and laminins in addition to structural collagen proteins (Data is available via ProteomeXchange with identifier PXD020606). COMatrix hydrogel is a naturally driven biomaterial with favorable biomechanical properties and protein content with potential application as a therapeutic biomaterial in ocular regeneration and tissue engineering. Impact statement Fabrication and application of decellularized porcine corneal extracellular matrix is an emerging approach for corneal tissue engineering and regeneration. There are several protocols for decellularization of porcine cornea with various efficiencies. Here, we are presenting an optimized protocol for decellularization of porcine cornea followed by fabrication of a thermoresponsive hydrogel from the decellularized cornea matrix. Moreover, the fabricated hydrogel was rheologically and compositionally characterized as crucial features to be employed for further application of this hydrogel in corneal tissue engineering and regeneration