Additional file 5 of Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis

Additional file 5. Results of LASSO selection

Additional file 7 of Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis

Additional file 7. Critical R scripts

Additional file 3 of Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis

Additional file 3. Results of comparison analysis among normal tissues and three Gleason score tumors

Additional file 1 of Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis

Additional file 1. Results of pan-cancer sites

Additional file 6 of Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis

Additional file 6. AUCs of model using all 8 biomarkers, PSA and age

Additional file 4 of Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis

Additional file 4. Results of comparison analysis between PRAD and other urinary samples

Additional file 2 of Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis

Additional file 2. Results of comparison analysis among five Gleason score tumors

Table_1_Antibody Response to SARS-CoV-2 in the First Batch of COVID-19 Patients in China by a Self-Developed Rapid IgM-IgG Test.docx

It has been over two years since the COVID-19 pandemic began and it is still an unprecedented global challenge. Here, we aim to characterize the antibody profile from a large batch of early COVID-19 cases in China, from January – March 2020. More than 1,000 serum samples from participants in Hubei and Zhejiang province were collected. A series of serum samples were also collected along the disease course from 70 patients in Shanghai and Chongqing for longitudinal analysis. The serologic assay (ALLtest) we developed was confirmed to have high sensitivity (92.58% - 97.55%) and high specificity (92.14% - 96.28%) for the detection of SARS-CoV-2 nucleocapsid-specific antibodies. Confirmed cases found in the Hubei Provincial Center for Disease Control and Prevention (HBCDC), showed a significantly (p = 0.0018) higher positive rate from the ALLtest than RNA test. Then, we further identified the disease course, age, sex, and symptoms that were correlating factors with our ALLtest results. In summary, we confirmed the high reliability of our ALLtest and its important role in COVID-19 diagnosis. The correlating factors we identified will require special attention during future clinical application.</p