Additional file 6 of Gene expression analysis reveals the tipping points during infant brain development for human and chimpanzee

Additional file 6. Detailed DNB genes and DEGs IPA analysis summary and network analysis results

Additional file 2 of Gene expression analysis reveals the tipping points during infant brain development for human and chimpanzee

Additional file 2. Detecting the tipping points for the infant brain development of human and chimpanzee. Detecting the tipping points for two data sets, human (a, b, c, d) and chimpanzee (e, f, g, h). The infant human contain 13 samples (age range from 0 to 0.9 years old). The infant chimpanzee contains 9 samples (age range from 0 to 6.3 years old). Subfigures a and e represent the composite index (see Methods, CI in Eq.(1)), Subfigures b and f represent the mean SDs in the DNB of human and chimpanzee (see Methods, SD in Eq.(1)), Subfigures c and g represent PCCs in the DNB (see Methods, PCCd in Eq.(1)), Subfigures d and h are the PCCs between the DNB and other molecules (see Methods, PCCo in Eq.(1)).The results of the figure show the effectiveness of the DNB model by using our data sets and 3 and 1 month are the tipping points of two species

Additional file 3 of Gene expression analysis reveals the tipping points during infant brain development for human and chimpanzee

Additional file 3. 371 DNBs of human and 132 DNBs of chimpanzee. There are one gene which are overlaps of two parts DNBs

Additional file 1 of Gene expression analysis reveals the tipping points during infant brain development for human and chimpanzee

Additional file 1. Hierarchical cluster analysis of normalized DPLEC datasets (Human, Chimpanzee, Monkey), based on 17,429 expressed genes. The red represents human, the blue represents chimpanzee and the yellow represents macaque

Additional file 5 of Gene expression analysis reveals the tipping points during infant brain development for human and chimpanzee

Additional file 5. Sample Characteristics

Additional file 4 of Gene expression analysis reveals the tipping points during infant brain development for human and chimpanzee

Additional file 4. The DEGs of human and chimpanzee around the tipping point. The overlap genes between DNBs and DEGs of two species

S1 File -

BackgroundAttention Deficit Hyperactivity Disorder (ADHD) is increasingly recognized as a major problem for children and their families in China. However, its influence on parental mental health has been seldom explored.ObjectiveTo examine the prevalence of attention deficit hyperactivity disorder in a community sample of children aged 6–13 years, and the extent to which it impacts parental mental health.MethodCross-sectional study of primary school pupils (number = 2497) in Deyang, Sichuan Province, South-West China. We used standardized instruments to identify children with ADHD symptoms and parent depression.ResultsThe prevalence of ADHD was 9.8%. Factors associated with the likelihood of ADHD, included family environment(P = 0.003), time spent with children(P = 0.01), parenting style(P = 0.01), and parental relationship, pupils self-harm and lower academic ability (P = 0.001). After controlling for other factors, having a child with ADHD increased the likelihood of parents’ depression (OR = 4.35, CI = 2.68~7.07), additional factors included parent relationship.ConclusionsADHD may be a common disorder among Chinese children, the symptoms of which may increase the likelihood of parent depression. There is a need for greater detection of ADHD in schools, acknowledgement of the challenges the disorder creates for academic success and family wellbeing, and psychoeducational tools for supporting parents of children with ADHD.</div

Additional file 1: of The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation

Figure S1. CD200R1 interacted with CD200. Cells were harvested as described in “Materials and Methods” and immunoprecipitation (IP) was performed to detect CD200-CD200R1 interaction at a molecular level. BV2 cells were transfected with FLAG-WT or FLAG-N44Q and co-cultured with neurons. Proteins in the cell lysates and immunoprecipitated proteins were subsequently analyzed by western blotting analysis. Data showed that CD200 bind more CD200R1 with WT than CD200R1 with N44Q. (TIF 279 kb

Pupil ADHD and family context factors (X²).

BackgroundAttention Deficit Hyperactivity Disorder (ADHD) is increasingly recognized as a major problem for children and their families in China. However, its influence on parental mental health has been seldom explored.ObjectiveTo examine the prevalence of attention deficit hyperactivity disorder in a community sample of children aged 6–13 years, and the extent to which it impacts parental mental health.MethodCross-sectional study of primary school pupils (number = 2497) in Deyang, Sichuan Province, South-West China. We used standardized instruments to identify children with ADHD symptoms and parent depression.ResultsThe prevalence of ADHD was 9.8%. Factors associated with the likelihood of ADHD, included family environment(P = 0.003), time spent with children(P = 0.01), parenting style(P = 0.01), and parental relationship, pupils self-harm and lower academic ability (P = 0.001). After controlling for other factors, having a child with ADHD increased the likelihood of parents’ depression (OR = 4.35, CI = 2.68~7.07), additional factors included parent relationship.ConclusionsADHD may be a common disorder among Chinese children, the symptoms of which may increase the likelihood of parent depression. There is a need for greater detection of ADHD in schools, acknowledgement of the challenges the disorder creates for academic success and family wellbeing, and psychoeducational tools for supporting parents of children with ADHD.</div

Trace Metal Ions in Hair from Frequent Hair Dyers in China and the Associated Effects on Photo-oxidative Damage

Human hairs are subject to oxidative modification when exposed to sunlight. In the present study, samples of human hair from Chinese volunteers that included frequent hair dyers and non-dyers were analyzed for metal ions such as iron, copper, magnesium, aluminum, zinc and lead. The generation of hydroxyl radicals during UVA (315–400 nm) photoageing was quantified and oxidative damages characterized by proteomic and SEM analysis. It was concluded that high levels of metal ions, particularly those derived from iron and copper, identified in the dyed hairs are associated with enhanced photoformation of hydroxyl radicals and resultant photooxidative damage of the hair. Reactive oxygen species, including hydroxyl radicals, generated via an electron transfer mechanism with hair photosensitizers react with hair proteins. Proteomic analysis of hair samples from frequent hair dyers, regardless of age and gender, showed an almost 1.6 fold increase in the protein oxidative modification levels compared to the undyed samples. As a result, a more pronounced physical damage including fragmentation and cross-linkage of cuticle scales was observed on the surface of dyed hair samples during the photoageing. This work is aimed at better understanding the role of metal ions in dyed hairs and their possible role in photosensitizing hair proteins. The results from this study are anticipated to contribute to the improved development of hair coloring cosmetics and hair care products