Data_Sheet_1_The Influence of Science Technology Engineering Arts Mathematics-Based Psychological Capital Combined With Ideological and Political Education on the Entrepreneurial Performance and Sports Morality of College Teachers and Students.docx

This study aims to alleviate the current tense employment situation and study the entrepreneurial situation of teachers and students in colleges and universities. Firstly, based on the educational concept of Science Technology Engineering Arts Mathematics (STEAM), Ideological and Political Education (IPE) is added to psychological capital to explore the effect of the combination of the two on entrepreneurial performance. An entrepreneurial performance impact model is constructed, and the questionnaire is set. Secondly, the influence of psychological capital combined with IPE on sports morality is explored, and a sports morality questionnaire is designed. Finally, the questionnaire results are analyzed. The results showed that most of the participants in the survey are under the age of 25. The 25- to 29-year-olds are the smallest among those surveyed. The respondents who participated in the survey had the most undergraduate degrees, accounting for 43.4%. The 40 items on entrepreneurial performance this time obey a normal distribution, and the scale has good reliability and validity. The main factor analysis results obtained by principal component analysis include 6 factors. Their total explanatory power exceeds 67%, and the six factors screened out this time are well represented. The model tolerance is between 0.45 and 0.5, and the Variance Inflation Factor (VIF) value is less than 10. The scale does not suffer from multi-collinearity issues. IPE significantly strengthens the effect of psychological capital on entrepreneurial performance. The influences of various sports on sportsmanship, bravery, self-confidence, and self-transcendence are significantly different, and the P value is less than 0.001. The difference in aggressiveness is less than 0.01, indicating that it is very significant. Different sports have significant differences in the cultivation of sports morality, and the P value is less than 0.05. The differences in self-discipline are also significant, and there are extremely significant differences in compliance with rules, and the P value here is less than 0.001. There are no significant differences in sporting qualities. IPE combined with psychological capital has a significant impact on entrepreneurial performance. These contents provide references for the entrepreneurship education of teachers and students in colleges and universities. The contribution lies in expanding the research on psychological capital in entrepreneurial performance and laying a foundation for the combination of psychological capital and IPE.</p

JBD866911_supplementary_appendix - A note on the cutoff values of alternative fit indices to evaluate measurement invariance for ESEM models

JBD866911_supplementary_appendix for A note on the cutoff values of alternative fit indices to evaluate measurement invariance for ESEM models by Ying Jin in International Journal of Behavioral Development</p

Toward Optimal Variance Reduction in Online Controlled Experiments

We study optimal variance reduction solutions for count and ratio metrics in online controlled experiments. Our methods apply flexible machine learning tools to incorporate covariates that are independent from the treatment but have predictive power for the outcomes, and employ the cross-fitting technique to remove the bias in complex machine learning models. We establish CLT-type asymptotic inference based on our estimators under mild convergence conditions. Our procedures are optimal (efficient) for the corresponding targets as long as the machine learning estimators are consistent, without any requirement for their convergence rates. In complement to the general optimal procedure, we also derive a linear adjustment method for ratio metrics as a special case that is computationally efficient and can flexibly incorporate any pretreatment covariates. We evaluate the proposed variance reduction procedures with comprehensive simulation studies and provide practical suggestions regarding commonly adopted assumptions in computing ratio metrics. When tested on real online experiment data from LinkedIn, the proposed optimal procedure for ratio metrics can reduce up to 80% of variance compared to the standard difference-in-mean estimator and also further reduce up to 30% of variance compared to the CUPED approach by going beyond linearity and incorporating a large number of extra covariates.</p

USJ770115_Supplementary_material – Supplemental material for Economic impacts of alternative greenspace configurations in fast growing cities: The case of Greater Beijing

<p>Supplemental material, USJ770115_Supplementary_material for Economic impacts of alternative greenspace configurations in fast growing cities: The case of Greater Beijing by Mingfei Ma, Ying Jin in Urban Studies</p

Efficient Synthesis of Methylene <i>exo</i>-Glycals: Another Use of Glycosylthiomethyl Chlorides

A new approach to the synthesis of methylene exo-glycals is described. Oxidation of glycosylthiolmethyl chloride (GTM-Cl) with mCPBA afforded the corresponding glycosylchloromethyl sulfone in almost quantitative yield, which underwent KOtBu-induced Ramberg−Bäcklund rearrangement to furnish the desired methylene exo-glycal in excellent yield

Spectroscopic Study on Water Diffusion in Poly(l-lactide)−Poly(ethylene glycol) Diblock Copolymer Film

Diffusion of water in a phase-separated poly(l-lactide)-b-poly(ethylene glycol) (PLLA−PEG) copolymer with both blocks crystallizable was investigated using time-resolved ATR-FTIR with deuterated water and 2D correlation analysis. Water molecules of three different states were identified in the copolymer matrix, and their formation sequence was determined. Perturbation of water on the copolymer structure was revealed. While the amorphous PLLA chains were not affected, upon water penetration, conformation distribution of crystalline PLLA chains was altered, which can be reversed upon removal of the water, and the PEG crystallinity in the copolymer was gradually destroyed and the process was not reversible. For the double amorphous PLLA−PEG film, water first associated with the more hydrophilic PEG chains and then interacted with the PLLA segments. For the double crystalline film, however, crystalline PLLA segments were first perturbed by the water before the crystalline PEG was affected. Finally, the water diffusion coefficient for the PLLA−PEG copolymer was measured and compared with that of the PLLA and PEG homopolymers

Long non-coding RNA RGMB-AS1 represses nasopharyngeal carcinoma progression via binding to forkhead box A1

Long non-coding RNA RGMB-AS1 (RGMB antisense RNA 1) plays a crucial role in tumor progression. However, its underlying mechanism in nasopharyngeal carcinoma (NPC) remains unclear. In this study, we analyzed the clinical significance of lncRNA RGMB-AS1 as a possible potential marker in NPC, and investigated the effect and mechanism of lncRNA RGMB-AS1 on proliferation, migration and epithelial mesenchymal transformation (EMT) of NPC by directly binding Forkhead box A1 (FOXA1) in vitro and in vivo. In conclusion, LncRNA RGMB-AS1 inhibits malignant behaviors and EMT by regulating FOXA1, and lncRNA RGMB-AS1 may be an important indicator of clinical prognosis.</p

Thioketal-Based Electrochemical Sensor Reveals Biphasic Effects of l‑DOPA on Neuroinflammation

Neuroinflammation is linked closely to neurodegenerative diseases, with reactive oxygen species (ROS) exacerbating neuronal damage. Traditional electrochemical sensors show promise in targeting cellular ROS to understand their role in neuropathogenesis and assess therapies. Nevertheless, these sensors face challenges in mitigating the ROS oxidation overpotential. We herein introduce an ROS oxidation-independent nucleic acid sensor for in situ ROS analysis and therapeutic assessment. The sensor comprises ionizable and thioketal (TK)-based lipids with methylene blue-tagged nucleic acids on a glass carbon electrode. ROS exposure triggers cleavage within the sensor’s thioketal moiety, detaching the nucleic acid from the electrode and yielding quantifiable results via square-wave voltammetry. Importantly, the sensor’s low potential window minimizes interference, ensuring precise ROS measurements with high selectivity. Using this sensor, we unveil levodopa’s dose-dependent biphasic effect on neuroinflammation: low doses alleviate oxidative stress, while high doses exacerbate it. The TK-based sensor offers a promising methodology for investigating neuroinflammation’s pathogenesis and screening potential treatments, advancing neurodegenerative disease research

Data_Sheet_1_Roles of Endothelial Motilin Receptor and Its Signal Transduction Pathway in Motilin-Induced Left Gastric Artery Relaxation in Dogs.pdf

Background: Motilin increases left gastric artery (LGA) blood flow in dogs via the endothelial motilin receptor (MLNR). This article investigates the signaling pathways of endothelial MLNR.Methods: Motilin-induced relaxation of LGA rings was assessed using wire myography. Nitric oxide (NO), and cyclic guanosine monophosphate (cGMP) levels were measured using an NO assay kit and cGMP ELISA kit, respectively.Results: Motilin concentration-dependently (EC50=9.1±1.2×10−8M) relaxed LGA rings precontracted with U46619 (thromboxane A2 receptor agonist). GM-109 (MLNR antagonist) significantly inhibited motilin-induced LGA relaxation and the production of NO and cGMP. N-ethylmaleimide (NEM; G-protein antagonist), U73122 [phospholipase C (PLC) inhibitor], and 2-aminoethyl diphenylborinate [2-APB; inositol trisphosphate (IP3) blocker] partially or completely blocked vasorelaxation. In contrast, chelerythrine [protein kinase C (PKC) inhibitor] and H89 [protein kinase A (PKA) inhibitor] had no such effect. Low-calcium or calcium-free Krebs solutions also reduced vasorelaxation. N-nitro-L-arginine methyl ester [L-NAME; nitric oxide synthase (NOS) inhibitor] and ODQ [soluble guanylyl cyclase (sGC) inhibitor] completely abolished vasodilation and synthesis of NO and cGMP. Indomethacin (cyclooxygenase inhibitor), 18α-glycyrrhetinic acid [18α-GA; myoendothelial gap junction (MEGJ) inhibitor], and K+ channel inhibition through high K+ concentrations or tetraethylammonium (TEA-Cl; KCa channel blocker) partially decreased vasorelaxation, whereas glibenclamide (KATP channel blocker) had no such effect.Conclusion: The current study suggests that motilin-induced LGA relaxation is dependent on endothelial MLNR through the G protein-PLC-IP3 pathway and Ca2+ influx. The NOS-NO-sGC-cGMP pathway, prostacyclin, MEGJ, and K+ channels (especially KCa) are involved in endothelial-dependent relaxation of vascular smooth muscle (VSM) cells.</p

3D Orientation Imaging of Polymer Chains with Polarization-Controlled Coherent Raman Microscopy

Despite the ubiquity of three-dimensional (3D) anisotropic materials, their 3D molecular alignment cannot be measured using conventional two-dimensional (2D) polarization imaging. Here, we present images of the 3D angles of molecular orientations with submicrometer spatial resolution acquired through polarization-controlled coherent anti-Stokes Raman scattering microscopy. The hyperspectral Raman data of a polyethylene (PE) film were converted into images, showing the polymer chains’ 3D angles and order parameters. The 3D orientation images of PE chains in ring-banded spherulites show that the azimuthal angles of the chains are perpendicular to the crystal growth direction, while the out-of-plane angles display limited-range oscillations synchronous with ring banding. The prevailing crystal growth model of fully twisting lamellae is inconsistent with the observed restricted oscillations of the out-of-plane direction, which are unobservable through conventional 2D projected imaging. This high-resolution, label-free, quantitative imaging of 3D molecular orientation can become a standard measurement tool for the microscopic structures of complex synthetic and biological materials