Comparison of incidence and hazard ratio of peptic ulcer disease stratified by sex, age and comorbidity between patients with and without early-onset cataract.

Comparison of incidence and hazard ratio of peptic ulcer disease stratified by sex, age and comorbidity between patients with and without early-onset cataract.</p

Cummulative incidence of peptic ulcer compared between patients with and without EOC.

Patients with EOC had a higher cumulative incidence of peptic ulcer than those without EOC.</p

Demographic characteristics and comorbidities of patients with and without early-onset cataract.

Demographic characteristics and comorbidities of patients with and without early-onset cataract.</p

Incidence of depression and anxiety, blepharitis cohort to non-blepharitis cohort rate ratio and Cox model measured hazards ratio by comorbidity.

<p>Rate^#, incidence rate, per 1,000 person-years; IRR*, incidence rate ratio.</p><p>Adjusted HR^†: adjusted for age, sex, diabetes, hyperlipidemia, hypertension, coronary artery disease and stroke.</p><p>*p<0.05.</p><p>**p<0.01.</p

DataSheet_1_Association between immune checkpoint inhibitor medication and uveitis: a population-based cohort study utilizing TriNetX database.pdf

ObjectiveTo explore the associations between the use of immune checkpoint inhibitors (ICIs) and the risk of developing uveitis among cancer patients.MethodsCancer patients who received ICI therapy and a comparison group of cancer patients who did not receive ICI therapy were retrospectively recruited from the TriNetX electronic heath-record registry. The outcome of interest was the development of new-onset uveitis. Propensity score matching based on a 1:1 ratio was conducted in order to reduce bias. Multi-variate cox proportional hazard models and Kaplan Meier method were also utilized to assess for the risk of uveitis among cancer patients who received ICI therapy.Results71931 cancer patients (54.7% male; 76.5% white; mean age at index 63.6 ± 12.2 years) who received ICI treatment (ICI group) and 71931 cancer patients (54.7% male; 77% white; mean age at index 63.5 ± 12.4 years) who never received ICI (comparison group) were recruited. Associated Kaplan-Meier curves showed significantly increased uveitis risk among the ICI group for all follow-up years (pConclusionA significantly increased risk for uveitis diseases was found among the ICI group from the first year of follow-up. Increased awareness should be promoted on the occurrence of uveitis among cancer patients receiving ICI therapy.</p

Incidence rates by sex, age and cohort, and blepharitis cohort to non-blepharitis cohort rate ratios and Cox model measured hazard ratios.

<p>PY, person-years; Rate^#, incidence per 1,000 person-years; IRR*, incidence rate ratio.</p><p>Adjusted HR^†: adjusted for age, sex, diabetes, hyperlipidemia, hypertension, coronary artery disease and stroke.</p><p>*p<0.05.</p><p>**p<0.01.</p

Blepharitis cohort to non-blepharitis cohort incidence rate ratio of anxiety and depression by quartile of follow-up years.

<p>Blepharitis cohort to non-blepharitis cohort incidence rate ratio of anxiety and depression by quartile of follow-up years.</p

Demographic characteristics and comorbidities in blepharitis cohort and non-blepharitis cohort.

<p>&:Chi-square test; t-test used to test means.</p

Comparison of non-blepharitis and blepharitis cohorts.

Comparison of non-blepharitis and blepharitis cohorts.</p

The cumulative incidence curves of ischemic stroke estimated by cause-specific Cox proportional hazard regression model.

The cumulative incidence curves of ischemic stroke estimated by cause-specific Cox proportional hazard regression model.</p