Flowchart of the selection of study participants.

*Methotrexate, sulfasalazine, hydroxychloroquine, leflunomide, tacrolimus, bucillamine, mizoribine, cyclosporine, infliximab, etanercept, adalimumab, golimumab, abatacept, tocilizumab, rituximab, and tofacitinib. **Systemic connective tissue disorders (International Classification of Diseases 10th revision [ICD-10] code: M30-M36), ankylosing spondylitis (ICD-10 code: M45), psoriatic and enteropathic arthropathies (ICD-10 code: M07), or juvenile arthritis (ICD-10 code: M08). RA, rheumatoid arthritis; DMARD, disease-modifying anti-rheumatic drug.</p

Comparison of mortality between the RA and control groups.

Comparison of mortality between the RA and control groups.</p

Comparison of rate, type, and distribution of disability between the RA and control groups.

Comparison of rate, type, and distribution of disability between the RA and control groups.</p

Health expenditure per capita for the rheumatoid arthritis (RA) and control group.

For interpretation, 1 US dollar is equal to 1100 Korean dollars. (A) Total health care costs. (B) Amount of out-of-pocket payment.</p

Sociodemographic characteristics of the RA and control groups.

Sociodemographic characteristics of the RA and control groups.</p

Uptake of LDL from each group into macrophages was visualized by fluorospectroscopy to detect NBD-cholesterol.

<p>CM, control male; RAM, rheumatoid arthritis male; CF, control female; RAF, rheumatoid arthritis female.</p

HDL₃ associated cholesteryl ester transfer protein (CETP) activity (A) and paraoxonase (PON) activity (B).

CM, control male; RAM, rheumatoid arthritis male; CF, control female; RAF, rheumatoid arthritis female.</p

Three-dimensional finite element analysis of combined loading of skirted foundations on non-homogeneous clay

Combined loading of shallow foundations is particularly relevant in offshore engineering as wind and wave loading cause significant lateral and moment forces to the foundations of offshore structures. Research to date has addressed either combined loading of strip footings on non-homogeneous soils (e.g. Bransby &amp; Randolph, 1998) or of circular footings on homogeneous soils (e.g. Taiebat &amp; Carter, 2000). The present paper contributes towards this database by presenting the results of three-dimensional finite element analyses, which have addressed the issues of combined loading, soil strength non-homogeneity and three-dimensional foundation geometry integrated in single analyses. Attention is focused on the effect of the degree of strength non homogeneity on the size and shape of the failure loci under combined vertical, moment and horizontal loading.</p

Representative photo of negatively-stained HDL₂ from RA patients and controls (electron microscopy).

All micrographs are shown at a magnification of 40,000×. The scale bar corresponds to 100 nm. Graphs show measured particle size and number from designated area. CM, control male; RAM, rheumatoid arthritis male; CF, control female; RAF, rheumatoid arthritis female.</p

Glycation extent of HDL based on fluorescence determination (A) and electrophoretic profiles of HDL as visualized by Coomassie Brilliant Blue staining (B).

<p>CM, control male; RAM, rheumatoid arthritis male; CF, control female; RAF, rheumatoid arthritis female.</p