Arvensic acids K and L, components of resin glycoside fraction from <i>Convolvulus arvensis</i>

Alkaline hydrolysis of the resin glycoside fraction of the whole plants of Convolvulus arvensis gave two new glycosidic acids, named arvensic acids K and L (1 and 2). Their structures were characterized on the basis of spectroscopic data as well as chemical evidence. They possessed a same pentasaccharide chain, composed of one D-fucose, three D-glucose and one L-rhamnose units. The aglycone of compound 1 was identified to be rarely existing 11S-hydroxyheptadecanoic acid, while compound 2 possessed 11S-hydroxyhexadecanoic acid as the aglycone. Their cytotoxic and anti-migration activities were also evaluated.</p

Achieving Colorful Ultralong-Lifetime Room-Temperature Phosphorescence Based on Benzocarbazole Derivatives through Resonance Energy Transfer

It is of practical significance to develop polymer-based room-temperature phosphorescence (RTP) materials with ultralong lifetime and multicolor afterglow. Herein, the benzocarbazole derivatives were selected and combined with a poly­(vinyl alcohol) (PVA) matrix by a coassembly strategy. Owing to the hydrogen-bonding interactions between benzocarbazole derivatives and the PVA matrix, the nonradiative transition and the quenching of triplet excitons are effectively inhibited. Therefore, the maximum phosphorescence emission lifetime of 2202.17 ms from ABfCz-PVA and the maximum phosphorescence quantum efficiency of 34.97% from ABtCz-PVA were obtained, respectively. In addition, commercially available dye molecules were selected to construct phosphorescent resonance energy transfer (PRET) systems for energy acceptors, enabling full-color afterglow emission in blue, green, yellow, red, and even white. Based on the characteristics of prepared RTP materials, multifunctional applications to flexibility, information encryption, and erasable drawing were deeply explored

Photo-Switchable Oxygen Vacancy as the Dynamic Active Site in the Photocatalytic NO Oxidation Reaction

Identifying the dynamic structural changes of the active sites in a catalytic reaction under realistic working conditions is a great challenge. In this work, we demonstrate that in situ electron paramagnetic resonance (EPR) technology is an important technique for the electronic-level recognition of the dynamic evolution of active sites over a defective BiOCl catalyst during the gas–solid photocatalytic reaction. The formation and recovery of photoexcited oxygen vacancies (PE-OVs) with or without UV light irradiation are experimentally verified, and these vacancies can be defined as photoswitchable OVs. The photoexcited dynamic OVs could function as genuine active sites to activate the O2 molecules via directional single-electron transfer from px or pz of Bi 6p to π2py* of the O2 molecules. In situ FT-IR spectra elucidate that the dynamic PE-OVs were available to promote the conversion of reaction intermediates to the final product. Thus, PE-OVs are identified as dynamic active sites for photocatalysis reactions, challenging the common view of the static OVs as active sites. This work provides an innovative concept of dynamic defects as real active sites for catalysis reactions

Additional file 1 of The identification of liver metastasis- and prognosis-associated genes in pancreatic ductal adenocarcinoma

Additional file 1: Figure S1. SPARC and TPM1 expression analysis in PADC based on GEPIA. Figure S2. The correlation of SPARC and TPM1 expression and clinicopathological parameters using the UALCAN database. Figure S3. Compared the expression of SPARC and TPM1 between metastasis and non-metastasis PDAC patients in TCGA dataset. Table S1. Information on the Microarray datasets. Table S2. Clinicopathological characteristics of the patients with PDAC. Table S3. The corrections of SPARC and TPM1 and tumor stage, lymphnode metastases and tumor grade

Additional file 1 of Childhood modifiable risk factors and later life chronic kidney disease: a systematic review

Supplementary Material

Image_2_Spontaneous pregnancy after tracking ovulation during menstruation: A case report of a woman with premature ovarian insufficiency and repeated failure of in vitro fertilization.JPEG

The diagnosis of premature ovarian insufficiency (POI) is devastating in women of reproductive age because of the small chance of spontaneous pregnancy. Here, we report a very rare case with POI and repeated failure of in vitro fertilization (IVF) where the final result was natural fertilization following guidance to have sexual intercourse during menstruation as ovulation was monitored. Estradiol valerate was used to increase the thickness of the endometrium and stop the menstrual bleeding. There was a serum level of 208.44 IU/L of human chorionic gonadotropin (HCG) 14 days after the ovulation. Later, a series of transvaginal ultrasounds also indicated a normal-appearing intra-uterine pregnancy. A healthy baby girl was delivered at term by means of cesarean section. Our report suggested that although the chance of spontaneous pregnancy is relatively low in patients with POI with repeated IVF failures, as long as ovulation does occur, even if it happens during menstruation, natural pregnancy is still worth trying with a series of proper and personalized treatments.</p

An innovative approach to manufacturing flexible decorative wood veneer using EVA film as adhesive and reinforcing materials

In order to solve the problems of easy cracking and poor flexibility of decorative wood veneer, a simple and efficient approach to manufacturing flexible decorative wood veneer was proposed. Ethylene-vinyl acetate (EVA) film was used as adhesive and reinforcing material for developing EVA film reinforced decorative wood veneer (EVA-RDV). The results showed that EVA film and Manchurian Ash decorative wood veneer could be well composited at 110 °C without special treatment. The flexibility was maintained at 4 ∼ 6 mm and the transverse tensile strength was 0.99 MPa, which was 412.5% higher than that of the original decorative veneer (DV). It was found that EVA film had better adaptability of veneer moisture content (MC). The cavity proportion was kept within 5%, and the flexibility was little affected. The surface bonding strength was maintained at a stable state of 0.8 ∼ 1 MPa (higher than the standard 0.4 MPa). Only 100 °C was needed to complete the surface decoration, and the optimal surface bonding strength reached 1.17 MPa. The water resistance of all decorative veneered Medium Density Fiberboards (MDF) met the requirements of indoor use in GB/T 15104-2006.</p

Optimizing the Chemical Recognition Process of a Fluorescent Chemosensor for α‑Ketoglutarate

α-Ketoglutarate (α-KA) can convert to 2-hydroxyglutarate (2-HG), which is confirmed to be associated with many diseases, especially with acute myeloid leukemia (AML). In this paper, a novel reaction-based chemosensor DT based on the typical Schiff-base reaction was designed for sensing the biomarker of α-KA, in which a diazanyl group as the recognition group was linked with a benzothiadiazole unit as the fluorophore moiety. Considering the typical Schiff-base reaction to generate hydrazones suffering from slow kinetics, particularly under neutral conditions, a series of parallel experiments was conducted for optimizing the chemical recognition process, including varying the solvent, reaction temperature, reactant concentration, and reaction rate. The optimum condition was established as a pH value, temperature, α-KA concentration, and response time of 5.7, 30 °C, 100 μM, and 20 min, respectively. Notably, in contrast with the initial 6.3-fold fluorescence enhancement, the remarkable 75-fold fluorescence enhancement ((<i>I</i> – <i>I</i>₀)/<i>I</i>₀ at 560 nm) was observed by optimizing the chemical recognition process of DT and α-KA. Finally, DT was carried out for the chemical recognition processing of α-KA in serum. We demonstrated that DT is selective for α-KA over other potential biologically interferences with similar structures and thus is suitable for detecting α-KA in serum. On the basis of the optimized chemical recognition process, DT shows high potential application for sensing α-KA with remarkable fluorescence enhancement. This work provided a potential method that is quick and convenient for sensing biomarker α-KA in serum. It is worth noting that without complicated pretreatment, utilizing a novel reaction-based fluorescent chemosensor may establish a new promising platform for clinical diagnosis biomarker

Frustrated Lewis Pair Sites Boosting CO₂ Photoreduction on Cs₂CuBr₄ Perovskite Quantum Dots

Lead (Pb) halide perovskite quantum dots (PQDs) are promising candidates for the photochemical reduction of CO2. However, the intrinsically weak adsorption and activation toward inert CO2 molecules have seriously hindered their practical application. This study reports alternative Cs2CuBr4 PQDs for gas–solid phase photocatalytic CO2 reduction under simulated solar irradiation. Cs2CuBr4 PQDs exhibited CO2 photoreduction performance with CH4 and CO yields of 74.81 and 148.98 μmol g–1, respectively. In situ diffuse reflectance infrared Fourier transform spectra and density functional theory calculations cooperatively revealed the synergistic strengthening of microelectronic polarization in Cs2CuBr4 PQDs induced by surface-frustrated Lewis pair-like properties and intrinsic Cu d-band properties facilitated robust CO2 adsorption and activation. This study demonstrated the potential of Cs2CuBr4 PQDs as a platform for highly efficient CO2 photoreduction and provided a distinct concept for CO2 adsorption and activation based on the catalytic mechanism of Cu-based PQDs