Data_Sheet_1_The use of Xuanbai Chengqi decoction on monkeypox disease through the estrone-target AR interaction.docx

IntroductionAfter COVID-19, there was an outbreak of a new infectious disease caused by monkeypox virus. So far, no specific drug has been found to treat it. Xuanbai Chengqi decoction (XBCQD) has shown effects against a variety of viruses in China.MethodsWe searched for the active compounds and potential targets for XBCQD from multiple open databases and literature. Monkeypox related targets were searched out from the OMIM and GeneCards databases. After determining the assumed targets of XBCQD for monkeypox treatment, we built the PPI network and used R for GO enrichment and KEGG pathway analysis. The interactions between the active compounds and the hub targets were investigated by molecular docking and molecular dynamics (MD) simulations.ResultsIn total, 5 active compounds and 10 hub targets of XBCQD were screened out. GO enrichment and KEGG analysis demonstrated that XBCQD plays a therapeutic role in monkeypox mainly by regulating signaling pathways related to viral infection and inflammatory response. The main active compound estrone binding to target AR was confirmed to be the best therapy choice for monkeypox.DiscussionThis study systematically explored the interactions between the bioactive compounds of XBCQD and the monkeypox-specific XBCQD targets using network pharmacological methods, bioinformatics analyses and molecular simulations, suggesting that XBCQD could have a beneficial therapeutic effect on monkeypox by reducing the inflammatory damage and viral replication via multiple pathways. The use of XBCQD on monkeypox disease was confirmed to be best worked through the estrone-target AR interaction. Our work could provide evidence and guidance for further research on the treatment of monkeypox disease.</p

Summary of the studies that examined the prognostic value of PD-L1 in SGC.

Summary of the studies that examined the prognostic value of PD-L1 in SGC.</p

sj-pdf-1-imr-10.1177_03000605211069202 - Supplemental material for Gastric adenocarcinoma with germ cell tumor components: a rare case report

Supplemental material, sj-pdf-1-imr-10.1177_03000605211069202 for Gastric adenocarcinoma with germ cell tumor components: a rare case report by Xu Han, Shu Wang, Hongyu He, Yao Sun and Jiannan Li in Journal of International Medical Research</p

Clinicopathological features of included studies.

(XLSX)</p

Data_Sheet_1_How Well Are Socioeconomic Factors Associated With Improved Outcomes for Infants Diagnosed With Early Childhood Developmental Delay? An Observational Study.docx

PurposeEarly childhood developmental delay remains problematic worldwide in terms of weight and the five domains of child development, including gross motor, fine motor, cognition, language, and social domains. Based on the World Health Organization (WHO) guideline and the theoretical domain framework, this study identified five key socioeconomic factors, such as parenting time during hospitalization, parental educational level, medical spending, distance to hospital, and medical insurance coverage, to describe how these five factors are associated with improved outcomes of developmental quotient (DQ) values and the weight of infants in a tertiary hospital.MethodsIn this prospective observational study, clinical and socioeconomic data were collected. Clinical data included the weight and DQ values of infants and other data relevant to the birth of infants. A National Developmental Scale was used to observe infants in five domains and calculate the DQ values of infants. These five domains include gross motor, fine motor, cognition, language, and social domains. Parenting time during hospitalizations was observed by a research nurse. Other socioeconomic factors were reported by parents and verified with system information.ResultsA total of 75 infants' parents were approached, of which 60 were recruited. The age of infants ranged from 75 to 274 days at the first admission. Increments of their weight and DQ values improved from −0.5 to 2.5 kg and from −13 to 63, respectively. More than half of the parents (54.1%) were at the level of minimum secondary education although the results were not statistically significant. However, there was a positive correlation between weight improvement and parenting time during hospitalization (r(58) = 0.258, p ConclusionParenting time during hospitalization, medical spending, distance to hospital, and medical insurance coverage are important factors for early childhood developmental delay in relation to possible hospital intervention and improved accessibility to health services for families in rural areas. Therefore, changes in the current medical scheme are needed because a universal medical subsidy among regions will reduce the financial burden of families and provide families with more access to the necessary health services that their children need.</p

The Projection of NL and Lung Cancer Genomic Profiles onto the Genomic Mouse Lung Development Frameworks Constructed from Three Different Mouse Gene Subsets

<div><p>In all cases, genomic PC1 of mouse lung development is positively correlated with lung development time. Mouse lung sample placements (blue circles) are nearly contiguous as a function of their stage of development. The separation between the human lung cancer subtypes in this mouse genomic development framework is defined by a class differentiation measure (see <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0030232#st2" target="_blank">Methods</a>). <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0030232#st003" target="_blank">Table S3</a> gives the score_pca values for the top-union algorithm for these gene set size parameters. Mouse, mouse lung development stages. </p> <p>(A) Human lung samples projected onto the mouse lung development genomic framework (genomic PC1 and PC3) of all 3,590 genes.</p> <p>(B) Same as (A), but for the mouse development framework constructed from the subset of 1,148 significantly differentially expressed genes in the human lung cancer subtypes.</p> <p>(C) Same as (B), but for the mouse development framework constructed from a further subset of 596 genes of the 1,148.</p></div

Fig 5 -

Forest plot for the association between programmed cell death ligand 1 (PD-L1) expression and (A) the progression-free survival (PFS); and (B) the disease-specific survival (DSS) of salivary gland carcinoma (SGC) patients. HR, hazard ratio; CI: confidence interval.</p

Risk of bias assessment using the Quality In Prognosis Studies (QUIPS) tool.

Risk of bias assessment using the Quality In Prognosis Studies (QUIPS) tool.</p

PRISMA checklist.

(DOCX)</p

sj-docx-1-nms-10.1177_14614448211050928 – Supplemental material for Evolution of the plandemic communication network among serial participants on Twitter

Supplemental material, sj-docx-1-nms-10.1177_14614448211050928 for Evolution of the plandemic communication network among serial participants on Twitter by Yu Xu, Yao Sun, Loni Hagen, Mihir Patel and Mary Falling in New Media & Society</p