Metabolic pathway network of responsive metabolites in alfalfa leaves infected with <i>P</i>. <i>medicaginis</i>.

The black, red, blue, light blue and crimson full and dotted box indicates that metabolites were detected by GC-MS from the alfalfa leaves, and the dotted box presents significant regulated metabolites in the inoculated leaves compared with the controls (VIP>1.0 and p<0.05). Yellow dotted box indicates that the metabolites were not detected by GC-MS from the alfalfa leaves, but were involved in the corresponding pathway. Green dotted ovals indicates that the metabolic pathway was associated with the regulated metabolites. (VIP, the variable importance for the projection; PEP, phosphoenolpyruvate; TCA cycle, tricarboxylic acid cycle). Red color indicates that the compound was significantly upregulated at later infection stages. Blue color indicates that the compound was significantly downregulated at later infection stages. Light blue color indicates that the compound was significantly downregulated over time. Crimson color indicates that the compound was almost significantly upregulated over time.</p

Heat map of significantly regulated metabolites in the alfalfa leaves between control and inoculated groups.

Metabolite levels in the leaves were shown as log10 ratios of values from infected versus uninfected groups at 2, 4, 6, 8, 12, 16, 20, 24, 26 and 28 days post inoculation (dpi). Yellow color shows upregulated compound levels, and the blue color indicates downregulated levels. Level of compounds in the inoculated leaves was significantly lower (SL) or significantly higher (SH) than in the control leaves. Inositol 1,3,4,5,6- is inositol 1,3,4,5,6-pentakisphosphate. Data were evaluated by student’s t test and p<0.05 has significant difference.</p

Data for: Numerical analysis of dynamic heating modulation during rapid cooling of fuel layer in an indirect-drive cryogenic target

This file contains all the research data for this revised manuscript

Multivariate statistical analysis of control samples and infected samples.

Principal component analysis (PCA) score plot for the inoculated samples (green) and control samples (blue) collected at 2, 4, 6, 8, 12, 16, 20, 24, 26 and 28 days, PC1 is 35.3% and PC2 is 17.2% (a); Orthogonal partial least-squares discriminant analysis (OPLS-DA) score plot (1+4 components), R2X(cum) = 0.739, R2Y(cum) = 1.000, Q2 = 0.817), R2X(cum) and R2Y(cum) are the cumulative modelled variations in the X and Y matrices, respectively, and Q2 value is a prediction error (b); Validation plots of the orthogonal partial least-squares discriminant analysis (POLS-DA) models acquired through 200 permutation tests for the control vs. inoculated groups. T [1] = scores for predictive component 1, to [1] = scores for orthogonal component 1. The ellipse shows the 95% confidence interval using Hotelling T2 statistics. R and Q were obtained after OPLS-DA permutation tests (n = 200), R2 intercept was 0.861, Q2 intercept was -0.933 (c).</p

Fold change values from pathogen-inoculated versus control groups at each time points.

Fold change values from pathogen-inoculated versus control groups at each time points.</p

Identification of 70 metabolites from the control and inoculated leaves and the determination of 16 significantly regulated metabolites associated with <i>P</i>. <i>medicaginis</i> infection.

Identification of 70 metabolites from the control and inoculated leaves and the determination of 16 significantly regulated metabolites associated with P. medicaginis infection.</p

Symptoms on alfalfa inoculated with <i>Phoma medicaginis</i> var. medicaginis.

The symptoms observed at 8 d (b), 19 d (c) and 26 d (d) after inoculation, and without inoculation (controls) (a).</p

Iron-Catalyzed Cascade Arene−Aldehyde Addition/Cyclizations for the Highly Efficient Synthesis of Xanthenes and Its Analogous: Observation of a C−C Bond Cleavage in Indole-Based Triarylmethanes

An efficient, general, and one-pot procedure for the synthesis of multisubstituted xanthene derivatives through Fe(III)-catalyzed reactions of 2-aryloxybenzaldehydes with electron-rich arenes has been developed. This method offers several advantages such as high selectivities, mild reaction conditions, and easily accessible starting materials. A mechanistic study revealed that a C−C bond cleavage of a triarylmethane intermediate might be involved in the domino process

Iron-Catalyzed Cascade Arene−Aldehyde Addition/Cyclizations for the Highly Efficient Synthesis of Xanthenes and Its Analogous: Observation of a C−C Bond Cleavage in Indole-Based Triarylmethanes

An efficient, general, and one-pot procedure for the synthesis of multisubstituted xanthene derivatives through Fe(III)-catalyzed reactions of 2-aryloxybenzaldehydes with electron-rich arenes has been developed. This method offers several advantages such as high selectivities, mild reaction conditions, and easily accessible starting materials. A mechanistic study revealed that a C−C bond cleavage of a triarylmethane intermediate might be involved in the domino process

Efficient Synthesis of 3-Iodoindenes via Lewis-Acid Catalyzed Friedel−Crafts Cyclization of Iodinated Allylic Alcohols

A convenient BF3·Et2O-catalyzed Friedel−Crafts cyclization of iodinated allylic alcohols is reported. The present reaction provides an efficient protocol to 3-iodo-1H-indene derivatives in good to high yields under mild conditions. Further, the iodoindene derivatives are valuable synthetic building blocks for elaboration of molecular complexity, such as in the construction of multiaryl substituted indenes by Suzuki coupling reaction