Конспект лекцій із навчальної дисципліни «Бухгалтерський та управлінський облік» для студентів за спеціальністю 073 - Менеджмент.

Data 4. 450 differentially expressed lincRNAs with significance (P <0.05, q <0.05). (XLSX 113 kb

Development on Chinese Version of Family Ritual Questionnaire

Family ritual questionnire (Chinese version) Data_Update

Trend and Factors of Late HIV Diagnosis Among HIV Patients Diagnosed from 2008 to 2012 in Kunming, China

Highly Active Antiretroviral Therapy (HAART) has dramatically improved the prognosis of HIV infection. For HAART to have the desired effect, however, HIV infections must diagnosed early. Early HIV testing can promote the initiation of safer behaviors in HIV-infected individuals that lessen transmission risk to contacts. It also enables people to initiate antiretroviral therapy when indicated. The objectives of this study were to: 1) identify factors associated with late HIV diagnosis among HIV-infected patients diagnosed from 2008 to 2012 in Kunming, Yunnan Province, China; 2) describe the trend of late HIV diagnosis over time in Kunming. A cross-sectional study was conducted based on secondary data extracted from the Chinese antiretroviral electronic database. HIV-infected patients who had their HIV diagnoses between 2008 and 2012 and who entered care within one year of their HIV diagnosis were included in the analysis. Late HIV diagnosis was defined as a person who progressed to a CD4+ cell count (less than 200 cells/µL) or to an AIDS-defining clinical event diagnosis within 12 months of the date of HIV diagnosis. Independent variables included age at HIV diagnosis, gender, transmission mode, area of residence, average income level, and GDP per capita. Log binomial regression models were conducted to identify factors associated with late HIV diagnosis and to describe linear trends of late HIV diagnosis over time. Age at HIV diagnosis and gender were independent predictors of late HIV diagnosis among the study participants. The relative prevalence was 1.29 (95%CI: 1.11, 1.49) times higher among individuals aged 28-38 compared with those aged 18-28, and PR increased as age increased. Men had 12% (95%CI: 1.04, 1.21) higher prevalence compared with women after controlling for relevant covariates. The stratified analysis showed female intravenous drug users (IDUs) had 27% (95%CI: 1.11, 1.45) higher prevalence compared with heterosexual women but this association was not significant among IDU men. This study indicates men, older adults, and female IDUs were at greater risk for late HIV diagnosis among HIV-infected patients in Kunming, Yunnan Province, China. Current interventions targeting young students and older adults are effective, but more intervention strategies should be developed targeting at men and female IDUs to promote early HIV testing among them

Comparative genomics of rumen methanogens: a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand

Methane emissions from agriculture represent around 9% of global anthropogenic greenhouse emissions. The single largest source of this methane is animal enteric fermentation, predominantly from ruminant livestock where it is produced mainly in their fermentative forestomach (or reticulo-rumen) by a group of archaea known as methanogens. In order to reduce methane emissions from ruminants, it is necessary to understand the role of methanogenic archaea in the rumen, and to identify their distinguishing characteristics that can be used to develop methane mitigation technologies. To gain insights into the role of methylotrophic methanogens in the rumen environment, two methanogens has been isolated from ovine rumen and their genomes were sequenced: methanogenic archaeaon ISO4-H5 of the order Methanomassiliicoccales and Methanobrevibacter sp. D5 of Methanobrevibacter gottschalkii clade. Genomic analysis suggests ISO4-H5 is an obligate hydrogen-dependent methylotrophic methanogen, able to use methanol and methylamines as substrates for methanogenesis. Like other organisms within this order, ISO4-H5 does not possess genes required for the first six steps of hydrogenotrophic methanogenesis. Comparison between the genomes of different members of the order Methanomassiliicoccales revealed strong conservation in energy metabolism, particularly in genes of the methylotrophic methanogenesis pathway, as well as in the biosynthesis and use of pyrrolysine. Unlike members of Methanomassiliicoccales from human sources, ISO4-H5 does not contain the genes required for production of coenzyme M, and requires external coenzyme M to survive. Methanobrevibacter sp. D5 is a hydrogenotrophic methanogen predicted to utilise CO2, H2 and formate as substrate, the comparison between the available Methanobrevibacter genomes has revealed a high conservation in energy metabolism and characteristics specific to each clade. The coexistence of Methanobrevibacter species in the rumen may be partly due to the large numbers of unique adhesin-like proteins, which may interact with different host surface or microorganisms and allow their unique niche to be established

Development on Chinese Version of Family Ritual Questionnaire

Family ritual questionnire (Chinese version) Dat

Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice

The source data underlying Figs 1b-f, 2a-e, 3b-e, 4b-e, 5b-h, 6b-f, 7c, and 8b and Supplementary Figs 2a, 2b (left), 3c, 4a, and 8b are provided as a Source Data file

Development on Chinese Version of Family Ritual Questionnaire

Family ritual questionnire (Chinese version) Data_Update

Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice

The source data underlying Figs 1b-f, 2a-e, 3b-e, 4b-e, 5b-h, 6b-f, 7c, and 8b and Supplementary Figs 2a, 2b (left), 3c, 4a, and 8b are provided as a Source Data file

Trend and Factors of Late HIV Diagnosis Among HIV Patients Diagnosed from 2008 to 2012 in Kunming, China

Highly Active Antiretroviral Therapy (HAART) has dramatically improved the prognosis of HIV infection. For HAART to have the desired effect, however, HIV infections must diagnosed early. Early HIV testing can promote the initiation of safer behaviors in HIV-infected individuals that lessen transmission risk to contacts. It also enables people to initiate antiretroviral therapy when indicated. The objectives of this study were to: 1) identify factors associated with late HIV diagnosis among HIV-infected patients diagnosed from 2008 to 2012 in Kunming, Yunnan Province, China; 2) describe the trend of late HIV diagnosis over time in Kunming. A cross-sectional study was conducted based on secondary data extracted from the Chinese antiretroviral electronic database. HIV-infected patients who had their HIV diagnoses between 2008 and 2012 and who entered care within one year of their HIV diagnosis were included in the analysis. Late HIV diagnosis was defined as a person who progressed to a CD4+ cell count (less than 200 cells/µL) or to an AIDS-defining clinical event diagnosis within 12 months of the date of HIV diagnosis. Independent variables included age at HIV diagnosis, gender, transmission mode, area of residence, average income level, and GDP per capita. Log binomial regression models were conducted to identify factors associated with late HIV diagnosis and to describe linear trends of late HIV diagnosis over time. Age at HIV diagnosis and gender were independent predictors of late HIV diagnosis among the study participants. The relative prevalence was 1.29 (95%CI: 1.11, 1.49) times higher among individuals aged 28-38 compared with those aged 18-28, and PR increased as age increased. Men had 12% (95%CI: 1.04, 1.21) higher prevalence compared with women after controlling for relevant covariates. The stratified analysis showed female intravenous drug users (IDUs) had 27% (95%CI: 1.11, 1.45) higher prevalence compared with heterosexual women but this association was not significant among IDU men. This study indicates men, older adults, and female IDUs were at greater risk for late HIV diagnosis among HIV-infected patients in Kunming, Yunnan Province, China. Current interventions targeting young students and older adults are effective, but more intervention strategies should be developed targeting at men and female IDUs to promote early HIV testing among them

Cyclophilin a represses reactive oxygen species generation and death of hypoxic non-small-cell lung cancer cells by degrading thioredoxin-interacting protein

Cyclophilin A (cypA) is overexpressed in many types of carcinomas, including non-small-cell lung cancer (NSCLC). However, the effect of anoxia, a critical feature of the carcinoma cell microenvironment, on cypA expression in NSCLC is unknown. Here, formaldehyde-fixed and paraffin-embedded samples were collected from 60 subjects with NSCLC. The protein expression levels of cypA and hypoxia-inducible factor-1α (HIF-1α) were evaluated using immunohistochemistry. Kaplan–Meier analysis showed that subjects with high cypA expression had remarkably shorter progression-free survival than those with low cypA expression. Furthermore, cypA expression levels were significantly related to HIF-1α expression levels (Spearman’s correlation = 0.34, P < 0.0001). To further assess the effect of cypA, an anoxic carcinoma cell model was established. CypA expression was remarkably upregulated in H1299 and A549 cell lines under hypoxic conditions. Overexpression of cypA restored hypoxia-impaired cell growth and prevented reactive oxygen species (ROS) production and cell death in hypoxic A549 and H1299 cells. However, these phenotypes were not altered by the inactive R55A mutant of cypA. Mechanistic studies demonstrated that cypA can bind to and degrade the tumor suppressor protein TXNIP in H1299 and A549 cells. Restored TXNIP expression in cypA-overexpressed and hypoxic NSCLC cells led to increased ROS levels and apoptotic cell numbers and decreased cell growth compared with cypA-overexpressed and hypoxic NSCLC cells. These findings indicate that anoxia results in an increase in cypA expression in NSCLC. Additionally, cypA served as an oncogene during hypoxia by interacting with TXNIP.</p