78 research outputs found
Correction to Catalytic Enantioselective Desymmetrization of 1,3-Diazido-2-propanol via Intramolecular Interception of Alkyl Azides with Diazo(aryl)acetates
Correction to Catalytic Enantioselective Desymmetrization
of 1,3-Diazido-2-propanol via Intramolecular Interception of Alkyl
Azides with Diazo(aryl)acetate
Catalytic Enantioselective Desymmetrization of 1,3-Diazido-2-propanol via Intramolecular Interception of Alkyl Azides with Diazo(aryl)acetates
The
first catalytic enantioselective desymmetrization of 1,3-diazido-2-propanol
via an intramolecular interception of alkyl azides by Cu–carbenoids
has been realized. A wide range of 1,3-diazidoisopropyl diazoÂ(aryl)Âacetates
were converted to cyclic α-imino esters in the presence of bisoxazoline
ligand (<i>S,S</i>)-Ph-Box with good to excellent yields,
and the enantiomeric excess was up to 97%
Catalytic Enantioselective Desymmetrization of 1,3-Diazido-2-propanol via Intramolecular Interception of Alkyl Azides with Diazo(aryl)acetates
The
first catalytic enantioselective desymmetrization of 1,3-diazido-2-propanol
via an intramolecular interception of alkyl azides by Cu–carbenoids
has been realized. A wide range of 1,3-diazidoisopropyl diazoÂ(aryl)Âacetates
were converted to cyclic α-imino esters in the presence of bisoxazoline
ligand (<i>S,S</i>)-Ph-Box with good to excellent yields,
and the enantiomeric excess was up to 97%
Catalytic Enantioselective Desymmetrization of 1,3-Diazido-2-propanol via Intramolecular Interception of Alkyl Azides with Diazo(aryl)acetates
The
first catalytic enantioselective desymmetrization of 1,3-diazido-2-propanol
via an intramolecular interception of alkyl azides by Cu–carbenoids
has been realized. A wide range of 1,3-diazidoisopropyl diazoÂ(aryl)Âacetates
were converted to cyclic α-imino esters in the presence of bisoxazoline
ligand (<i>S,S</i>)-Ph-Box with good to excellent yields,
and the enantiomeric excess was up to 97%
La tierra : bosquejos de la vida rural
A designed
Tf<sub>2</sub>O-promoted intramolecular Schmidt reaction
of 2-substituted ω-azido carboxylic acids was demonstrated.
Tf<sub>2</sub>O was used as an activation reagent for the carboxylic
acid, and ω-azido anhydride was in situ generated, releasing
a molecular TfOH, which acted as an acid promoter for the Schmidt
process. A series of 2-substituted pyrrolidines was produced and acetylated
for better purification. The strategy was also efficient for conversion
of a 4-substituted ω-azido carboxylic acid to the tricyclic
lactam
Iridium(III)-Based PD-L1 Agonist Regulates p62 and ATF3 for Enhanced Cancer Immunotherapy
Anti-PD-L1
immunotherapy, a new lung cancer treatment,
is limited
to a few patients due to low PD-L1 expression and tumor immunosuppression.
To address these challenges, the upregulation of PD-L1 has the potential
to elevate the response rate and efficiency of anti-PD-L1 and alleviate
the immunosuppression of the tumor microenvironment. Herein, we developed
a novel usnic acid-derived Iridium(III) complex, Ir-UA, that boosts PD-L1 expression and converts “cold tumors”
to “hot”. Subsequently, we administered Ir-UA combined with anti-PD-L1 in mice, which effectively inhibited tumor
growth and promoted CD4+ and CD8+ T cell infiltration.
To our knowledge, Ir-UA is the first iridium-based complex
to stimulate the expression of PD-L1 by explicitly regulating its
transcription factors, which not only provides a promising platform
for immune checkpoint blockade but, more importantly, provides an
effective treatment strategy for patients with low PD-L1 expression
Iridium(III)-Based PD-L1 Agonist Regulates p62 and ATF3 for Enhanced Cancer Immunotherapy
Anti-PD-L1
immunotherapy, a new lung cancer treatment,
is limited
to a few patients due to low PD-L1 expression and tumor immunosuppression.
To address these challenges, the upregulation of PD-L1 has the potential
to elevate the response rate and efficiency of anti-PD-L1 and alleviate
the immunosuppression of the tumor microenvironment. Herein, we developed
a novel usnic acid-derived Iridium(III) complex, Ir-UA, that boosts PD-L1 expression and converts “cold tumors”
to “hot”. Subsequently, we administered Ir-UA combined with anti-PD-L1 in mice, which effectively inhibited tumor
growth and promoted CD4+ and CD8+ T cell infiltration.
To our knowledge, Ir-UA is the first iridium-based complex
to stimulate the expression of PD-L1 by explicitly regulating its
transcription factors, which not only provides a promising platform
for immune checkpoint blockade but, more importantly, provides an
effective treatment strategy for patients with low PD-L1 expression
Preparation of Optically Active <i>cis</i>-Cyclopropane Carboxylates: Cyclopropanation of α‑Silyl Stryenes with Aryldiazoacetates and Desilylation of the Resulting Silyl Cyclopropanes
Optically
active <i>cis</i>-cyclopropane carboxylates
are prepared via the Rh<sub>2</sub>(<i>S</i>-PTAD)<sub>4</sub>-catalyzed cyclopropanation of α-silyl styrenes with aryl diazoacetates
followed by desilylation of the resulting silyl cyclopropane carboxylates.
The conjugation of the aryl ring with CC bond and π
stacking are proposed for the stereoselectivity of cyclopropanation,
and configuration inversion is observed with the desilylation process
Genetic association study of <i>TERT</i> gene variants with chronic kidney disease susceptibility in the Chinese population
The incidence and mortality of chronic kidney disease (CKD) are increasing globally. Studies have demonstrated the significance of genetic risk factors in the progression of CKD. Telomerase reverse transcriptase (TERT) may be implicated in the development of CKD. This study aimed to investigate the correlation between TERT gene variants and susceptibility to CKD in the Chinese population. A total of 507 patients with CKD and 510 healthy controls were recruited for this case-control study. Four candidate loci were identified using the MassARRAY platform. Logistic regression analysis was employed to assess the association between TERT gene variants and the risk of CKD. The false positive reporting probability (FPRP) method was utilized to evaluate the validity of statistically significant associations. The multifactorial dimensionality reduction (MDR) method was used to evaluate the interaction between SNPs and the risk of CKD. Furthermore, discrepancies in the clinical features of subjects with diverse genotypes were evaluated using one-way analysis of variance (ANOVA). Our findings revealed a correlation between rs2735940 and rs4635969 and an increased risk of CKD. Stratification analysis indicated that rs4635969 was related to an increased risk of CKD in different subgroups (age ≤ 50 years and male). MDR analysis indicated that the two-site model (rs2735940 and rs4635969) was the best prediction model. Furthermore, the rs2735940 GG genotype was found to be linked to an increased level of microalbuminuria (MAU) in patients with CKD. Our study is the first to reveal a connection between TERT gene variants and susceptibility to CKD, providing new insights into the field of nephrology.</p
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