Clinical stage of the studies included in the meta-analysis.

<p>^& The value is percentage</p><p>* Grading</p><p>^<b>#</b> Tumor stage</p><p>NA not available.</p><p>Clinical stage of the studies included in the meta-analysis.</p

A funnel plot of the 14 included studies.

<p>A funnel plot of the 14 included studies.</p

A flow diagram of the search process.

<p>A flow diagram of the search process.</p

Simultaneous Single-Particle Superlocalization and Rotational Tracking

Superlocalization of single molecules and nanoparticles has become an essential procedure to bring new insights into nanoscale structures and dynamics of biological systems. In the present study, superlocalization is combined with the newly introduced differential interference contrast (DIC) microscopy-based single-particle orientation and rotational tracking. The new technique overcomes the difficulty in localization of the antisymmetric DIC point spread function by using a dual-modality microscope configuration for simultaneous rotational tracking and localization of single gold nanorods with nanometer-scale precision. The new imaging setup has been applied to study the steric hindrance induced by relatively large cargos in the microtubule gliding assay and to track nanocargos in the crowded cellular environment. This technique has great potential in the study of biological processes where both localization and rotational information are required

A Forest plot of the pooled RR of recurrence for the IBR and Control groups.

<p>A Forest plot of the pooled RR of recurrence for the IBR and Control groups.</p

Structure based sequence alignment of TNKS1, TNKS2, and other PARP family members.

<p>Key residues Pro1187 (following deletion of two amino acids) and His1201 of the induced pocket in TNKS1 are highlighted, together with their equivalent residues in other PARP proteins, to illustrate the poor conservation of these amino acids.</p

A Forest plot of the pooled RR of DFS for the IBR and Control groups.

<p>A Forest plot of the pooled RR of DFS for the IBR and Control groups.</p

Simultaneous Single-Particle Superlocalization and Rotational Tracking

Superlocalization of single molecules and nanoparticles has become an essential procedure to bring new insights into nanoscale structures and dynamics of biological systems. In the present study, superlocalization is combined with the newly introduced differential interference contrast (DIC) microscopy-based single-particle orientation and rotational tracking. The new technique overcomes the difficulty in localization of the antisymmetric DIC point spread function by using a dual-modality microscope configuration for simultaneous rotational tracking and localization of single gold nanorods with nanometer-scale precision. The new imaging setup has been applied to study the steric hindrance induced by relatively large cargos in the microtubule gliding assay and to track nanocargos in the crowded cellular environment. This technique has great potential in the study of biological processes where both localization and rotational information are required

Sensitive analysis by excluding each single study.

<p>Sensitive analysis by excluding each single study.</p

Crystal Structure of the TNKS1/IWR2 complex.

<p>(A) Surface representation of TNKS1 (colored in wheat) with IWR2 (colored in green) bound. XAV939 (colored in yellow) from the crystal structure of TNKS2/XAV939 is superimposed to illustrate that IWR2 binds to a different pocket other than the nicotinamide pocket. (B) Superposition of crystal structures of TNKS1/IWR2 (colored in wheat and green) and apo TNKS1 (colored in cyan), with residues Phe1188 and His1201 in sticks, to illustrate the opening of the induced pocket in TNKS1 upon IWR2 binding. IWR2 binds to TNKS1 through three highlighted hydrogen bonds. (C) The induced pocket, showing the hydrogen bond and hydrophobic interactions between IWR2 and TNKS1 residues, colored as in (A).</p