Additional file 1 of Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cells

Additional file 1: Fig. S1. Representative flow cytometric analysis of HSPC markers CD34, CD43, and CD45 in floating cells on day 16 of NK cell differentiation culture. Fig. S2. Analysis of TIM3 surface expression by flow cytometric analysis. Fig. S3. Western blot analysis of various intracellular signaling pathways in CARTIM3 NK-92 cells in response to recombinant human TIM3 (200 μg/mL) at 4 hours in comparison to WT NK-92 cells

Chiral Metal–Organic Framework Decorated with TEMPO Radicals for Sequential Oxidation/Asymmetric Cyanation Catalysis

A chiral porous metal–organic framework (MOF) decorated with radicals has been successfully constructed by cocrystallizing achiral (2,2,6,6-tetramethylpiperidin-1-yl)­oxyl (TEMPO)-substituted tricarboxylate and enantiopure VO­(salen)-derived dipyridine ligands. The chiral MOF can function as an efficient heterogeneous catalyst for the sequential alcohol oxidation/asymmetric cyanation of aldehyde reactions with enhanced activity and enantioselectivity compared to the homogeneous counterpart

Aerobic Synthesis of Substituted Quinoline from Aldehyde and Aniline: Copper-Catalyzed Intermolecular C–H Active and C–C Formative Cyclization

An efficient method for the direct synthesis of substituted quinolines from anilines and aldehydes through C–H functionalization, C–C/C–N bond formation, and C–C bond cleavage has been developed. The method is simple and practical and employs air as an oxidant

I₂‑Catalyzed Synthesis of Substituted Pyrroles from α‑Amino Carbonyl Compounds and Aldehydes

A direct method for the synthesis of 1,3,4-triarylpyrroles was achieved easily from cyclization of α-amino carbonyl compounds and aldehydes catalyzed by I₂. Various substituted groups can be employed, and this reaction can proceed smoothly in moderate to good yields

I₂‑Mediated Oxidative Cyclization for Synthesis of Substituted Indolizines

A direct method for the synthesis of substituted indolizines by means of I₂-mediated oxidative tandem cyclization via C–N/C–C bond formation was developed. Various substituted aromatic/aliphatic enolizable aldehydes and 2-pyridylacetates/acetonitrile/acetone proceeded smoothly in this transformation, and the desired products were generated in moderate to good yields

Iodine-Mediated Thiolation of Substituted Naphthols/Naphthylamines and Arylsulfonyl Hydrazides via C(sp²)–H Bond Functionalization

A direct method has been developed for iodine-mediated thiolation of naphthols/naphthylamines and arylsulfonyl hydrazides through the formation of C–S bond and cleavage of S–N/S–O bonds. In this transformation, a range of valuable thioethers are easily achieved in moderate to good yields