Radical Cation Salt-Promoted Catalytic Aerobic sp³ C–H Oxidation: Construction of Quinoline-Fused Lactones and Lactams

A direct construction of quinoline-fused lactones and lactams was achieved by sp³ C–H bond oxidation of <i>N</i>-aryl glycine esters and amides under catalytic radical cation salt-induced conditions. These polycyclic products are formed in a single step from readily accessible starting materials, and this method provides a new synthetic approach to this class of heterocycles

Catalytic Radical Cation Salt Induced C_sp³–H Functionalization of Glycine Derivatives: Synthesis of Substituted Quinolines

A domino C_sp³–H functionalization of glycine derivatives was achieved under catalytic radical cation salt induced conditions, producing a series of quinolines. The proposed mechanism shows that a peroxyl radical cation, which is generated by the coupling between O₂ and TBPA^+•, might be involved to initiate the catalytic oxidation

Approach to Construct Polysubstituted 1,2-Dihydronaphtho[2,1‑<i>b</i>]furans and Their Aerobic Oxidative Aromatization

Triarylaminium salt was disclosed as an efficient initiator for the novel Friedel–Crafts alkylation/annulation cascade reaction between chalcone epoxides and 2-naphthols to construct polysubstituted 1,2-dihydronaphtho­[2,1-<i>b</i>]­furans. The DDQ/NaNO₂/O₂ catalytic system was first applied to the aerobic oxidative aromatization of heterocycles, and a simple and efficient one-pot tandem FC alkylation/annulation/aerobic oxidative aromatization procedure was also developed for the synthesis of complex naphtho­[2,1-<i>b</i>]­furans

Approach to Construct Polysubstituted 1,2-Dihydronaphtho[2,1‑<i>b</i>]furans and Their Aerobic Oxidative Aromatization

Triarylaminium salt was disclosed as an efficient initiator for the novel Friedel–Crafts alkylation/annulation cascade reaction between chalcone epoxides and 2-naphthols to construct polysubstituted 1,2-dihydronaphtho­[2,1-<i>b</i>]­furans. The DDQ/NaNO₂/O₂ catalytic system was first applied to the aerobic oxidative aromatization of heterocycles, and a simple and efficient one-pot tandem FC alkylation/annulation/aerobic oxidative aromatization procedure was also developed for the synthesis of complex naphtho­[2,1-<i>b</i>]­furans

Approach to Construct Polysubstituted 1,2-Dihydronaphtho[2,1‑<i>b</i>]furans and Their Aerobic Oxidative Aromatization

Triarylaminium salt was disclosed as an efficient initiator for the novel Friedel–Crafts alkylation/annulation cascade reaction between chalcone epoxides and 2-naphthols to construct polysubstituted 1,2-dihydronaphtho­[2,1-<i>b</i>]­furans. The DDQ/NaNO₂/O₂ catalytic system was first applied to the aerobic oxidative aromatization of heterocycles, and a simple and efficient one-pot tandem FC alkylation/annulation/aerobic oxidative aromatization procedure was also developed for the synthesis of complex naphtho­[2,1-<i>b</i>]­furans

Approach to Construct Polysubstituted 1,2-Dihydronaphtho[2,1‑<i>b</i>]furans and Their Aerobic Oxidative Aromatization

Triarylaminium salt was disclosed as an efficient initiator for the novel Friedel–Crafts alkylation/annulation cascade reaction between chalcone epoxides and 2-naphthols to construct polysubstituted 1,2-dihydronaphtho­[2,1-<i>b</i>]­furans. The DDQ/NaNO₂/O₂ catalytic system was first applied to the aerobic oxidative aromatization of heterocycles, and a simple and efficient one-pot tandem FC alkylation/annulation/aerobic oxidative aromatization procedure was also developed for the synthesis of complex naphtho­[2,1-<i>b</i>]­furans

Catalytic sp³ C–H Oxidation of Peptides and Their Analogues by Radical Cation Salts: From Glycine Amides to Quinolines

A catalytic α-sp³ C–H oxidation of peptides and glycine amides was achieved under radical cation salt catalysis in the presence of O₂, producing a series of substituted quinolines. The scope of this reaction shows good functional group tolerance and high efficiency of the oxidative functionalization

Catalytic sp³ C–H Oxidation of Peptides and Their Analogues by Radical Cation Salts: From Glycine Amides to Quinolines

A catalytic α-sp³ C–H oxidation of peptides and glycine amides was achieved under radical cation salt catalysis in the presence of O₂, producing a series of substituted quinolines. The scope of this reaction shows good functional group tolerance and high efficiency of the oxidative functionalization