24 research outputs found
Phospholipid Bilayer-Coated Aluminum Nanoparticles as an Effective Vaccine Adjuvant-Delivery System
The <i>p</i>hospho<i>l</i>ipid bilayer-coated <i>a</i>luminum <i>n</i>anoparticles (PLANs), formed
via chemisorption, were prepared by reverse ethanol injection-lyophilization
(REIL) utilizing the phosphophilicity of aluminum. The anhydrous antigen-loaded
PLANs obtained by REIL proved stable, satisfying using the controlled-temperature-chain
instead of the integrated cold-chain for distribution, and could be
rehydrated to reconstitute instantly an aqueous suspension of the
antigen-PLANs, which were more readily taken up by antigen-presenting
cells and, when given subcutaneously to mice, induced more robust
antigen-specific humoral and cellular immunoresponses but less local
inflammation than the antigen-alum. Thus, the PLANs are a useful vaccine
adjuvant-delivery system with advantages over the widely used naked
alum
MSHF: A Multi-Source Heterogeneous Fundus (MSHF) Dataset for Image Quality Assessment
MSHF: A Multi-Source Heterogeneous Fundus (MSHF) Dataset for Image Quality Assessment</p
Additional file 1: of Naringin ameliorates the high glucose-induced rat mesangial cell inflammatory reaction by modulating the NLRP3 Inflammasome
Key summary points. Diabetic kidney disease (DKD) is one of the most serious chronic complications of diabetes mellitus (DM), is a strong risk factor for cardiovascular diseases, and is a major cause of end stage kidney disease. The pathogenesis of DKD is complex and there are no effective measures to treat it currently.The aim of this study was to investigate the expression of the NLRP3-inflammasome under high glucose conditions, the effects of naringin during these conditions, and elucidate the role of naringin in the pathogenesis of DKD. Our results confirmed that naringin can regulate the NLRP3-Caspase-1-IL-1β / IL-18 signaling pathway by the NLRP3 inflammasome, which can improve DKD by playing an anti-inflammatory role.This study provides new insights into the nephroprotective mechanism of naringin to improve DKD by anti-inflammatory responses. (DOCX 12 kb
sj-docx-2-dhj-10.1177_20552076241247374 - Supplemental material for COVID-19 surveillance based on consumer wearable devices
Supplemental material, sj-docx-2-dhj-10.1177_20552076241247374 for COVID-19 surveillance based on consumer wearable devices by Chunbo Zhang, Aijun Sun, Jiping Liao, Chunbo Zhang, Kunyao Yu, Xiaoyu Ma and Guangfa Wang in DIGITAL HEALTH</p
Additional file 1: of Transcriptional response to sulfide in the Echiuran Worm Urechis unicinctus by digital gene expression analysis
The list of differentially expressed genes for Urechis unicinctus in response to sulfide. (XLSX 606Â kb
sj-docx-1-dhj-10.1177_20552076241247374 - Supplemental material for COVID-19 surveillance based on consumer wearable devices
Supplemental material, sj-docx-1-dhj-10.1177_20552076241247374 for COVID-19 surveillance based on consumer wearable devices by Chunbo Zhang, Aijun Sun, Jiping Liao, Chunbo Zhang, Kunyao Yu, Xiaoyu Ma and Guangfa Wang in DIGITAL HEALTH</p
Naringin restrained oxidative stress injury by activating Nrf2 antioxidant pathway.
<p>The concentration of MDA (A), the activity of SOD(B) and GSH-Px(C) in kidney tissues were detected. Data were expressed as means ± SD, n = 6. (D) The ROS production in HBZY-1 cells was evaluated by flow cytometry and ROS generation rates were shown. Data were expressed as means ± SD, n = 3. (E) The protein levels of Nrf2 and HO-1 in kidney tissues or HBZY-1 cells were detected by western blot. Results represent three independent experiments. (F) The DNA binding activities of Nrf2 in kidney tissues were assessed by EMSA assay. Data were expressed as means ± SD, n = 5. (G) The HO-1 activities in kidney tissues were determined. Data were expressed as means ± SD, n = 6.<sup>a-d</sup> Means with different superscripts are significantly different (P< 0.05).</p
Naringin suppressed NF-κ B signaling pathway activation.
<p>(A) The protein levels of p-I κ B α, I κ B α and NF-κ B in kidney tissues and HBZY-1 cells were determined by western blot. Results represent three independent experiments. (B) The distribution change of NF-κ B in HBZY-1 cells was observed by immunofluorescence assay. Results represent three independent experiments. (C) The DNA binding activities of NF-κ B in kidney tissues were assessed by EMSA assay. Data were expressed as means ± SD, n = 5.<sup>a-c</sup> Means with different superscripts are significantly different (P< 0.05).</p
Naringin mitigated changes of pathomorphology and kidney injury biochemical indexes.
<p>(A) The pathological changes of renal tissues were investigated by PAS staining(400×). The glomerular injury and tubular injury scores were shown. (B) Body weight and percentage change in weight of rats. (C) Food intake per rat per day. (D) The ratios of kidney weight/ body weight were calculated. The concentrations of BUN (E), Cr(F), and UP(G) were detected. Results represent three independent experiments. Data were expressed as means ± SD, n = 6.<sup>a-d</sup> Means with different superscripts are significantly different (P< 0.05).</p
Synthesis and Characterization of Novel 1,4-Bis(carbazolyl)benzene Derivatives with Blue-Violet Two-Photon-Excited Fluorescence
Novel
fluorescent two-photon absorption molecules containing bis(carbazolyl)benzene
as the central unit and phenylethynyl moieties as peripheral groups
(Cz-Ps) are synthesized and characterized. In these molecules, two
carbazolyl moieties are linked with benzene at the 9-position and
synthesized by a concise process involving nucleophilic substitution
between the cyclopentadienyliron complexes of dichloroarenes and phenylethynyl
carbazole, followed by photolysis. The optimal structures of Cz-Ps
reveal that two carbazolyl rings linked by a benzene ring are not
planar. This feature prevents the electron conjugation of the molecule
from extending throughout the whole molecule and allows Cz-Ps to realize
blue-violet emissions and high fluorescence quantum yield. With increasing
number of conjugated phenylacetylene structures in Cz-Ps, the maximal
absorption and emission peaks were red-shifted. The quadrupolar compound
DMoCz-P shows strong one-photon and two-photon activities. The resulting
molecules are also thermally stable with high glass transition temperatures
due to the rigid bicarbazole central unit. This work has demonstrated
that using bis(carbazolyl)benzene as central building block could
enhance two-photon absorption (TPA) performance and also provides
a possible general synthetic strategy for a series of bis(carbazolyl)benzene
derivatives, which would advance the understanding of the rational
design of new organic optical materials