Kaplan-Meier analyses of the differential protective effects of a history of TC on BC-specific survival between young and old patients.

A, comparisons of the effects of a history of TC on BC-specific survival curves in BC/TC and matched BC-only patients between the group aged B, comparisons of the effects of a history of TC on BC-specific survival curves in BC-1st and matched BC-only patients between the group aged C, comparisons of the effects of a history of TC on BC-specific survival curves in TC-1st and matched BC-only patients between the group aged BC, breast cancer; TC, thyroid cancer; BC-only, patients only with a diagnosis of breast cancer and without a history of thyroid cancer; BC/TC, breast cancer patients also with a history of thyroid cancer diagnosed any time—either before or after the diagnosis of breast cancer; BC-1st, breast cancer was diagnosed first, followed by diagnosis of thyroid cancer; TC-1st, thyroid cancer was diagnosed first, followed by diagnosis of breast cancer.</p

Kaplan-Meier analysis of the effect of a history of TC on BC-specific and overall survivals of patients in various settings.

A, comparison of BC-specific survival curves between BC/TC and matched BC-only patients; B, comparison of BC-specific survival curves between BC-1st and matched BC-only patients; C, comparison of overall survival curves between BC-1st and matched BC-only patients. D, comparison of BC-specific survival curves between TC-1st and matched BC-only patients. BC, breast cancer; TC, thyroid cancer; BC-only, patients only with a diagnosis of breast cancer and without a history of thyroid cancer; BC/TC, breast cancer patients also with a history of thyroid cancer diagnosed any time—either before or after the diagnosis of breast cancer; BC-1st, breast cancer was diagnosed first, followed by the diagnosis of thyroid cancer; TC-1st, thyroid cancer was diagnosed first, followed by the diagnosis of breast cancer.</p

Effects of a history of thyroid cancer on breast cancer-specific mortality—Deaths per 1000 person-years and hazard ratios.

Effects of a history of thyroid cancer on breast cancer-specific mortality—Deaths per 1000 person-years and hazard ratios.</p

Comparison of clinicopathological characteristics of breast cancer in various clinical settings.

Comparison of clinicopathological characteristics of breast cancer in various clinical settings.</p

Differential protective effects of a history of thyroid cancer on breast cancer-specific mortality in patients at age<50years and age≥50years at the diagnosis of breast cancer.

Differential protective effects of a history of thyroid cancer on breast cancer-specific mortality in patients at age<50years and age≥50years at the diagnosis of breast cancer.</p

Consistency of DM genes across different datasets for each cancer.

#<p>Each dataset was denoted by the following nomenclature: initial character of the cancer type followed by the total number of samples of the dataset.</p><p>*DM-S denotes DM genes from the shorter list;</p><p>**DM-L denotes DM genes from the longer list.</p>$<p>POG₁₂ denotes the score from the shorter list to the longer list;</p>$$<p>POG₂₁ denotes the score from the longer list to the shorter list.</p>¥<p>Consistency denotes the percentage of overlapping genes which showed the same methylation directions across the two datasets.</p

Consistency of DE genes across different datasets for each cancer.

<p>*DE-S denotes DE genes from the shorter list;</p><p>**DE-L denotes DE genes from the longer list.</p

Batch effects on tumour samples for nine cancer types.

<p>(a) different batches and different laboratories; (b) the same laboratory but different batches; (c) the same batch but different laboratories; (d) Hierarchical clustering the tumour samples of ovarian serous cystadenocarcinoma in batch 9 and batch 12. For a cancer type denoted in the x-axis in graph a, b or c, a box plot in the y-axis represents the percentage of probes significantly susceptible to different batch conditions. The percentage takes value ranging from 0 (no susceptible probe) to 1 (100% susceptible probes). Each box stretches from the lower hinge (defined as the 25th percentile) to the upper hinge (the 75th percentile) and the median is shown as a line across the box.</p

Concordance between differential methylation and differential expression.

§<p>Gene number denotes the number of hypermethylated (or hypomethylated) genes which were determined to be differentially expressed in the expression data.</p

The datasets of nine cancer types for analyzing batch effects.

<p>The datasets of nine cancer types for analyzing batch effects.</p