181 research outputs found

    Effect of rapamycin and CQ on sevoflurane-induced apoptosis in the hippocampus analyzed by using TUNEL staining.

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    <p>(A) Representative photomicrographs showing TUNEL-positive cells in the hippocampus of aged rats in each group, n = 3. (B) A statistical chart of the ratio of TUNEL-positive cells/total cells, 3 rats in each group and 5 fields were observed in each rat. Data are presented as mean ± SD,*<i>P</i> < 0.05 or **<i>P</i> < 0.01, <sup>#</sup><i>P</i> > 0.05.</p

    Ultrastructural changes of apoptotic neurons in sevoflurane group.

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    <p>These degenerating neurons showed an advanced stage of apoptosis, with chromatin clumping, condensation and margination (arrow), (a) a control rat. (b) a sevoflurane treated rat, Scale bar = 2 µm.</p

    Giant Topological Nontrivial Band Gaps in Chloridized Gallium Bismuthide

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    Quantum spin Hall (QSH) effect is promising for achieving dissipationless transport devices but presently is achieved only at extremely low temperature. Searching for the large-gap QSH insulators with strong spin–orbit coupling (SOC) is the key to increase the operating temperature. We demonstrate theoretically that this can be solved in the chloridized gallium bismuthide (GaBiCl<sub>2</sub>) monolayer, which has nontrivial gaps of 0.95 eV at the Γ point, and 0.65 eV for bulk, as well as gapless edge states in the nanoribbon structures. The nontrivial gaps due to the band inversion and SOC are robust against external strain. The realization of the GaBiCl<sub>2</sub> monolayer will be beneficial for achieving QSH effect and related applications at high temperatures

    Immunohistochemistry of CHOP and Caspase-12 in hippocampus.

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    <p>(a) CHOP immunostain in control group ×400. (b) CHOP immunostain in sevoflurane group ×400. (c) Caspase-12 immunostain in control group ×400. (d) Caspase-12 immunostain in sevoflurane group ×400. (e) Numbers of CHOP and Caspase-12-positive cells. (f) Optical density of CHOP and Caspase-12-positive cells. Data are presented as mean ± SD. *<i>P</i><0.05, <i>vs</i> the control group.</p

    Sevoflurane induced apoptosis of cells in the hippocampus of aged rats.

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    <p>Apoptosis was examined by the TUNEL method. Upper: Photomicrographs of TUNEL-positive cells. (a) Control group. (b) Sevoflurane group. (c) Number of TUNEL-positive cells in each group. Data are presented as mean ± SD. *<i>P</i><0.05, <i>vs</i> control group.</p
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