Utilization of CO₂ as a C1 Building Block in a Tandem Asymmetric A³ Coupling-Carboxylative Cyclization Sequence to 2‑Oxazolidinones

We report a tandem asymmetric aldehyde–alkyne–amine (A³) coupling-carboxylative cyclization sequence for the highly enantioselective synthesis of chiral <i>N</i>-aryl 2-oxazolidinones. This is a rare example of a multicatalyst-promoted asymmetric tandem reaction using CO₂ as a C1 synthon. Notably, the copper species and ligand from the upstream A³ reaction are internally reused to facilitate the downstream silver-catalyzed carboxylative cyclization

Additional file 1 of Vineyard microclimate alterations induced by black inter-row mulch through transcriptome reshaped the flavoromics of cabernet sauvignon grapes

Supplementary Material