The Proton of Alcohols as Hydrogen Source in Diboron-Mediated Nickel-Catalyzed Asymmetric Transfer Hydrogenation of Cyclic <i>N</i>‑Sulfonyl Imines

The proton of alcohols as the sole hydrogen source in diboron-mediated nickel-catalyzed asymmetric transfer hydrogenation of cyclic N-sulfonyl imines has been developed, providing the chiral cyclic sulfamidates in excellent enantioselectivities. The mechanistic investigations suggested that the proton of alcohols could be activated by tetrahydroxydiboron to form active nickel hydride species

Palladium-Catalyzed Asymmetric Hydrogenation of Unprotected 3‑Substituted Indoles

A palladium-catalyzed asymmetric hydrogenation of unprotected 3-substituted indoles was developed, providing a series of 3-substituted indolines in excellent yields with ≤94.4:5.6 er. The large sterically hindered bisphosphine ligand played a crucial role in the enantioselective control. In addition, the gram-scale hydrogenation experiment and product derivatizations were performed successfully

Self-Assembled Cobalt–Nickel Bimetallic-Organic Framework Materials with High Supercapacitor Performance

Two new metal–organic frameworks (MOFs), [Co(bcpp)(bbip)]·H2O (Co-MOF) and [Ni(bcpp)(bbip)]·H2O (Ni-MOF), have been generated based on a V-type flexible carboxylic ligand 3,5-bis(4-carboxyl phenoxy) pyridine (H2bcpp) and a rigid N-donor ligand 1,1′-(1,4-phenylene)bis(1H-benzimidazole) (bbip) by a solvothermal method. Co-MOF and Ni-MOF are isostructural with a 2-fold interpenetrated layered structure. Moreover, a series of bimetallic CoxNiy-MOFs (x/y = 1:1, 2.5:1, 2.75:1, 3:1, 3.25:1, and 3.5:1) were obtained by using one-pot synthesis. Owing to their mixed metallic components and internal layered structure, the bimetallic CoxNiy-MOFs possess a remarkable electrochemical storage property. Significantly, the Co2.75Ni1-MOF has high specific capacitance (699 F g–1) at 0.5 A g–1 and good cycling durability (retained 72.7% over 3100 turns). Additionally, an asymmetrical ultra-capacitor based on Co2.75Ni1-MOF and activated carbon (AC) delivers a maximum energy density of 20.44 Wh kg–1 at 387.49 W kg–1 and a high cycle-to-cycle stability with 85.4% of the primary capacitance over 15,000 turns

Silver-Mediated Decarboxylative C–S Cross-Coupling of Aliphatic Carboxylic Acids under Mild Conditions

A silver-mediated decarboxylative C–S cross-coupling reaction of aliphatic carboxylic acid is described. This reaction occurs smoothly under mild conditions and shows good tolerance of functional groups. It provides an alternative approach for the synthesis of alkyl aryl sulfides

Design and Synthesis of Planar-Chiral Oxazole–Pyridine <i>N</i>,<i>N</i>‑Ligands: Application in Palladium-Catalyzed Asymmetric Acetoxylative Cyclization

The development of chiral ligands to fine-tune the stereocontrol has been recognized as a crucial pillar of asymmetric catalysis. In contrast to the well-developed chiral pyridine–pyridine-type and pyridine–oxazoline-type ligands, chiral oxazole–pyridine-type ligands have rarely been exploited. In this study, a class of [2.2]­paracyclophane-based planar-chiral oxazole–pyridine N,N-ligands have been designed and synthesized. These ligands presented a superior performance in the enantioselective palladium-catalyzed asymmetric acetoxylative cyclization of alkyne-tethered cyclohexadienones, providing the chiral cis-hydrobenzofurans that belong to bioactive molecules with potent NF-κB inhibition in broad substrate scope. These results demonstrated the promising potential of the chiral oxazole–pyridine ligands as an efficient type of N,N-ligand scaffold

Double-track sign and the varied signal of thrombus.

<p>A 46-year old female patient with left transverse sinus stenosis. Hyperdensity of thrombus (cord sign) on non-contrast CT (A). Thrombus was isointense on T1WI (B) and hypointense on T2WI (C) which demonstrated an acute stage of thrombus. Double-track sign (arrow) was detected on axial Gd-enhanced T1WI (D). Severe stenosis was confirmed on MRV which showed a linear signal of blood flow in the left transverse sinus (E) (Time from MRI to MRV was 2.5 hours). No remission in headache in the patient after anticoagulant therapy for one week, and follow-up scan showed that the thrombus was hyperintense on T1WI (F) and hypointense on T2WI (G), which demonstrated an early sub-acute stage of thrombus. Transverse sinus stenosis was confirmed on DSA which showed the filling deficiency in the left transverse sinus (H) (Time from MRI to DSA was 3 hours).</p

Additional file 1: Figure S1. of A feasible diagnostic approach for the translocation carrier from the indication of products of conception

MLPA analysis with the kit P070-B2 confirmed the terminal deletions and duplications of Case 1 to 9. Red asterisks indicate the deleted regions, and blue asterisks indicate the duplicated regions. (TIFF 13493 kb

Recruitment flow diagram.

<p>Flow diagram demonstrates patient’s recruitment and imaging finding of the double-track sign.</p

Double-track sign and sinus recanalization.

<p>A 42-year old male patient with left transverse sinus stenosis. Isointense on T1WI (A) and hypointense on T2WI (B) demonstrated an acute stage of thrombus. Double-track sign (arrow) was showed on axial Gd-enhanced T1WI (C). Transverse sinus stenosis was confirmed on MRV which showed a linear signal of blood flow in the left transverse sinus on MRV (D) (Time from MRI to MRV was 3 hours). Follow-up scan after 2 weeks of anticoagulation therapy showed that the stenosis was ameliorated than before on MRV (E), and the double-track sign disappeared on axial Gd-enhanced T1WI after the recanalization (F) (Time from MRI to MRV was 6 hours).</p

Transverse sinus occlusion without double-track sign.

<p>A 38-year old male patient with right transverse sinus occlusion. The thrombus was hypointense on T1WI (A) and T2WI (B), and double-track sign was not observed in right transverse sinus on axial Gd-enhanced T1WI (C). Transverse sinus occlusion was confirmed on MRV which showed a lack of blood flow signal in the right transverse sinus (D) (Time from MRI to MRV was 2 hours).</p