9,961 research outputs found

    A Collaborative B2E Based on A P2P Platform

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    Companies, large and small, are rapidly adopting Business-to-Employee (B2E) applications hoping to improve productivity of their work force. However, most B2E applications do not provide a good sense of community and lack of collaboration and interaction among its users. Consequently, employees are not motivated to fully utilize the contents and information provided by these applications. Peer-to-peer (P2P) computing is proven to be a good platform that provides and supports community by empowering users to collaborate and interact with one another. In this paper, we propose an approach to provide collaboration in B2E applications based on a P2P platform

    A Knowledge Assimilation Schema for Acquiring Technical Knowledge

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    It has always been a challenge for business students to acquire technical knowledge. Such challenges are more pronounced at urban minority universities where many returning students often have additional obstacles that prevent them from learning as traditional students do. In response to the situation, we have developed a learning tool, called the Knowledge Assimilation Schema (KAS), that guides students to focus on the development of their knowledge structures rather than the collection of isolated knowledge entities. The learning tool has two major components: a knowledge representation framework that facilitates structural understanding and a knowledge acquisition process that steers deeper learning. Initial feedback and results from KAS have shown a noticeable improvement in conceptual learning of technical subjects, especially among nontraditional students

    Modulation of Ca2+-dependent anion secretion by protein kinase C in normal and cystic fibrosis pancreatic duct cells

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    AbstractThe study investigated the role of protein kinase C (PKC) in the modulation of agonist-induced Ca2+-dependent anion secretion by pancreatic duct cells. The short-circuit current (ISC) technique was used to examine the effect of PKC activation and inhibition on subsequent ATP, angiotensin II and ionomycin-activated anion secretion by normal (CAPAN-1) and cystic fibrosis (CFPAC-1) pancreatic duct cells. The ISC responses induced by the Ca2+-mobilizing agents, which had been previously shown to be attributed to anion secretion, were enhanced in both CAPAN-1 and CFPAC-1 cells by PKC inhibitors, staurosporine, calphostin C or chelerythrine. On the contrary, a PKC activator, phorbol 12-myristate 13-acetate (PMA), was found to suppress the agonist-induced ISC in CFPAC-1 cells and the ionomycin-induced ISC in CAPAN-1 cells. An inactive form of PMA, 4αd-phorbol 12,13-didecanote (4αD), was found to exert insignificant effect on the agonist-induced ISC, indicating a specific effect of PMA. Our data suggest a role of PKC in modulating agonist-induced Ca2+-dependent anion secretion by pancreatic duct cells. Therapeutic strategy to augment Ca2+-activated anion secretion by cystic fibrosis pancreatic duct cells may be achieved by inhibition or down-regulation of PKC

    Assuring E-Commerce Business Activities

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    Trust is imperative for conducting online transactions. To reduce online risks and foster trust, assurance service providers, such as TRUSTe, BBBonline, and WebTrust, audit online businesses to assure their compliance with principles and criteria for e-commerce business activities. Of these assurance service providers, WebTrust offers the most comprehensive services, including programs for business to consumer and business to business transactions, certification authorities (CA) and service providers. WebTrust jointly developed by the American Institute of Certified Public Accountants (AICPA) and the Canadian Institute of Chartered Accountants (CICA) offers best practices and a framework of measurable controls for electronic businesses, and thus, fosters online trust and confidence that are critical to the success of electronic commerce. As e-commerce matures, WebTrust will play an increasingly important role in CA-based e-commerce as well as in the applications service provider industry
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