Rapid and Sensitive Biomolecular Screening with Encoded Macroporous Hydrogel Photonic Beads

We present a new method to prepare inverse opaline photonic beads with good spherical shape and superior optical performance by simply introducing an interfacial tension system into a template replication method. When the scaffolds of these beads were composed of poly(ethylene glycol) diacrylate hydrogel, they could provide a homogeneous water surrounding, which remedied many shortcomings of biomolecular microcarriers introduced by the presence of the solid surface of them. The suspension array, which used these macroporous hydrogel photonic beads as coding elements, showed obvious advantages in multiplexed capability, rapid biomolecular screening (within 12 min), and highly sensitive detection (with limit of detection of ∼10−12 M)

Fluorinated Defect-Engineered Acetylenic Polymers with Separated Active Centers for Switching the Photosensitized Activation Pathway of Peroxymonosulfate

The engineering of conjugated acetylenic polymers (CAPs) has great potential for photosensitized oxyanion activation, wherein their catalytic performance can be further advanced by incorporating artificial defects, while relevant reports are rare. Herein, we deliberately introduce the fluorinated defect into the structure of poly­(1,3,5-triethynylbenzene) (PTEB) via copper-surface mediated Glaser polycondensation (denote as PTEB-Fx). PTEB-Fx exhibits a surface with an abundance of acetylene moieties that possess a strong affinity for capturing oxyanions through preferential binding to peroxy-bonds of oxyanions. Meanwhile, the adjacent fluorinated defects effectively delocalize π-electrons, narrow the optical bandgap, and facilitate charge separation, thereby optimizing kinetics and thermodynamics of peroxymonosulfate (PMS) activation. Such spatial separated active centers leads to a synergistic effect involving the enhanced oxidation ability of holes (h+) and the elongation of the O–H bond in PMS, which triggers a switch in the activation pathway toward oxidative activation for the generation of singlet oxygen (1O2), as opposed to the conventional reductive activation course yielding radical species (•OH and SO4•–). Additionally, PTEB-Fx featuring inherent self-standing merit overcomes challenges associated with limited light energy utilization and the cumbersome retrieval of powder photosensitizers, thus broadening its potential for large-scale application

Pharmacokinetics, pharmacodynamics, safety and immunogenicity of recombinant, fully human anti-RANKL monoclonal antibody (MW031) versus denosumab in Chinese healthy subjects: a single-center, randomized, double-blind, single-dose, parallel-controlled trial

MW031 is a biosimilar candidate of denosumab (Prolia®). This study aimed to compare the pharmacokinetics, pharmacodynamics, safety and immunogenicity of MW031 to denosumab in healthy Chinese participants. In this single-center, randomized, double-blind, parallel-controlled, single-dose trial, participants were given 60 mg MW031 (N = 58) or denosumab (N = 61) by subcutaneous injection and observed for 140 days. The primary endpoint was the bioequivalence of PK parameters (Cmax, AUC0-∞), and secondary endpoints including PD parameter, safety, and immunogenicity. A comparison of main PK parameters showed that the geometric mean ratios (GMR) (90% confidence intervals [CIs]) of AUC0-∞ and Cmax for MW031 over denosumab were 105.48% (98.96%, 112.43%) and 98.58% (92.78%, 104.75%), respectively. The inter-CV values of AUC0-∞ and Cmax for MW031 ranged from 19.9% to 23.1%. PD parameter (sCTX) in the MW031 and denosumab groups were similar, and the positivity rates of immunogenicity were 0% in both groups. This study also showed similar safety profiles in both groups, and there were no drug-related, high-incidence and previously unreported adverse reactions. This trial confirmed similar pharmacokinetic profiles of MW031 and denosumab in healthy male participants, and pharmacodynamic profile, immunogenicity and safety were comparable for both drugs. NCT04798313; CTR20201149</p

Interlayer Structure and Chemistry Engineering of MXene-Based Anode for Effective Capture of Chloride Anions in Asymmetric Capacitive Deionization

Negatively charged surfaces and readily oxidizabile characteristics fundamentally restrict the use of MXene building blocks as anodes for anion intercalation. Herein, by embedding bacterial cellulose nanofibers with conformal polypyrrole coating (BC@PPy) and populating them between MXene (Ti3C2Tx) interlayers, we enable the fabricated MXene/BC@PPy (MBP) composite films to be highly efficient anodes for Cl–-capturing in asymmetric capacitive deionization (CDI) systems. Performance gains are realized due to the surface electronegativity of MXene nanosheets becoming compensated by positively charged BC@PPy nanofibers, alleviating electrostatic repulsion, thus realizing reversible Cl– intercalation. More crucially, the anodization voltage of MBP is effectively enhanced as a result of the increase of the Ti valence state in MXene nanosheets with the addition of the BC@PPy spacer. Furthermore, BC@PPy nanopillars effectively enlarge the interlayer space for facile Cl– de-/intercalation, improve the vertical electron transfer between loosely deposited MXene nanosheets, and perform as additional active materials for Cl–-capturing. Consequently, the MBP anode exhibits a promising desalination capacity of up to 17.56 mg g–1 at 1.2 V with a high capacity retention of 94.6% after 30 cycles in an asymmetric CDI system. This work offers a simple and effective strategy to unlock the application potential of MXene building blocks as anodes for Cl–-capturing in electrochemical desalination