Data for: Modeling gasoline demand in the United States: A flexible semiparametric approach

Abstract of associated article: The focus of this paper is on the modeling and estimation of quarterly state-level gasoline demand in the United States. The existing literature may not appropriately evaluate the price elasticity and income elasticity of gasoline demand. Most studies fail to address the possible heterogeneity in gasoline demand elasticities that may arise from a variety of sources. The endogeneity issue of gasoline price has remained redundant throughout the literature. I address these challenges using a flexible demand model and a recently developed estimation technique. The econometric approach allows for functional coefficients to accommodate the heterogeneity in demand elasticities. Several instrumental variables are used to investigate the endogeneity of gasoline price. The estimation results provide strong evidence of heterogeneous gasoline demand elasticities across states and over time. Some state-level attributes along with income and macroeconomic shocks are the potential sources of heterogeneity

LINC00974 sponges miR-33a to facilitate cell proliferation, invasion, and EMT of ovarian cancer through HMGB2 upregulation

Abstract The function and mechanism of long intergenic non-protein coding RNA 974 (LINC00974) are rarely reported in ovarian cancer (OC). The study aimed to investigate how LINC00974 affects the progression of OC. The expression levels of LINC00974, microRNA-33a (miR-33a), and high mobility group box 2 (HMGB2) mRNA were detected by qRT-PCR. The LINC00974/miR-33a/HMGB2 axis was confirmed by dual-luciferase reporter, RNA-binding protein immunoprecipitation (RIP), and biotinylated RNA pull-down assays. A series of in vitro experiments were employed to assess the effects of LINC00974/miR-33a/HMGB2 axis on the proliferation, invasion and epithelial mesenchymal transition (EMT) of OC cells. Results showed that LINC00974 and HMGB2 mRNA expression were upregulated in OC cells, while miR-33a expression was downregulated. HMGB2 was a direct target gene of miR-33a. LINC00974 act as a competing endogenous RNA (ceRNA) to directly bind with miR-33a, thereby upregulated HMGB2 expression. Notably, silencing of LINC00974 suppressed cell proliferation, invasion and EMT of OC cells, whereas miR-33a knockdown partially reversed the phenotypes of LINC00974 on OC cells. Overall, our study demonstrated that LINC00974 sponges miR-33a to promote cell proliferation, invasion, and EMT of OC through HMGB2 upregulation. LINC00974/miR-33a/HMGB2 axis may be an important signaling pathway in the progression of OC.</div

Table S3 Physiological measurements (Mean±SD) at different time during exposure under different experimental conditions..docx

the effects of different time on human physiological response

Fig. S3 Pictures of collecting expired air and measuring respiratory ventilation rate in climate chamber..docx

During the measurement, participants were asked to breathe normally through the breathing mask and data were recorded continuously for 2.5 min

Table S2 Specifications of all instruments and manufacturer data..docx

All instruments were calibrated by the manufacturers prior to the experimental sessions, and instrument accuracy and specification are listed in the supplementary materials section

Fig. S1 Outdoor climate conditions from Aug 1 to Oct 31, in 2017..docx

Daily outdoor air temperatures and humidity levels were recorded between August and October 2017 in Changsha, China, where the temperature exposure experiments were conducted

Dynamical switching of lasing emission by exceptional point modulation in coupled microcavities

In a non-Hermitian optical system with loss and gain, an exceptional point (EP) will arise under specific parameters where the eigenvalues and eigenstates exhibit simultaneous coalescence. Here we report a dynamical switching of lasing behavior in a non-Hermitian system composed of coupled microcavities by modulating the EPs. Utilizing the effect of gain, loss and coupling on the eigenstates of coupled microcavities, the evolution path of the eigenvalues related to the laser emission characteristics can be modulated. As a result, the lasing emission property of the coupled cavities exhibits an dynamical switching behavior, which can also be effectively controlled by tuning the gain and loss of the cavities. Moreover, the evolution behavior in a more complicated system composed of three coupled microcavities is investigated, which shows a better tunability compared with the two-microcavity system. Our results have correlated the EPs in non-Hermitian system with lasing emission in complex microcavity systems, which shows great potential for realizing dynamical, ultrafast and multifunctional optoelectronic devices for on-chip integrations

Facilitators and barriers of initiation and maintenance of physical activity among people with coronary heart disease: a qualitative study

We aimed to describe the facilitators and barriers of physical activity for patients with coronary heart disease. A qualitative descriptive study using semi-structured interviews was conducted with 15 participants with coronary heart disease. The interview guide was developed based on a multi-theory model. Interviews were audio-recorded, transcribed verbatim, and analyzed using a thematic analysis. Two main themes were identified: facilitators of initiation and maintenance of physical activity (behavioral motivation, perceived benefits, behavioral confidence, supportive physical environment, positive emotional experience, self-regulation, supportive social environment, illness perception, and excellent self-control), barriers of initiation and maintenance of physical activity (perceived barriers, restricted physical environment, psychological distress, insufficient social support, and poor self-control). This study presents an in-depth theory-based exploration of facilitators and barriers to initiating and maintaining physical activity among people with coronary heart disease. Relevant factors should be taken into account to increase their effectiveness when designing the target interventions to encourage a physically active lifestyle in this population. Before commencing cardiac rehabilitation, it is imperative to assess patients with coronary heart disease (CHD) to ascertain whether they have limited activity capacity, psychological distress, insufficient social support, and poor self-control.A customized cardiac rehabilitation plan should be meticulously devised for each patient with CHD.For patients in the early stage of initiating physical activity (PA), rehabilitation professionals should assist them in recognizing the severity of their condition and the advantages of engaging in PA.Rehabilitation professionals should also promote active utilization of social networks, stimulate CHD patients’ motivation, and enhance their behavioral confidence.When guiding patients during the maintenance stage of PA, it is essential to regularly evaluate their psychological well-being, assist them in self-regulation based on their physical condition, and foster the development of self-control.Rehabilitation professionals should consistently provide social support to reinforce the patients’ motivation to maintain their PA behavior. Before commencing cardiac rehabilitation, it is imperative to assess patients with coronary heart disease (CHD) to ascertain whether they have limited activity capacity, psychological distress, insufficient social support, and poor self-control. A customized cardiac rehabilitation plan should be meticulously devised for each patient with CHD. For patients in the early stage of initiating physical activity (PA), rehabilitation professionals should assist them in recognizing the severity of their condition and the advantages of engaging in PA. Rehabilitation professionals should also promote active utilization of social networks, stimulate CHD patients’ motivation, and enhance their behavioral confidence. When guiding patients during the maintenance stage of PA, it is essential to regularly evaluate their psychological well-being, assist them in self-regulation based on their physical condition, and foster the development of self-control. Rehabilitation professionals should consistently provide social support to reinforce the patients’ motivation to maintain their PA behavior.</p

Acid-Responsive Multifunctional Zeolitic Imidazolate Framework‑8 (ZIF-8) Nanocomposites for Tumor Chemo-Photothermal Synergistic Therapy

Camptothecin (CPT), a broad-spectrum anticancer drug, has been extensively used clinically. However, its hydrophobic properties seriously hinder its antitumor therapeutic effect. Herein, we synthesized acid-degradable Fe3O4@poly­(vinylpyrrolidone) (Fe3O4@PVP)/gold nanoclusters@zeolitic imidazolate framework-8 composite nanoparticles (ZIF-8CNPs) via a facile method and utilized them as carriers to efficiently load CPT. The excellent fluorescence properties of gold nanoclusters (AuNCs) and the photothermal properties of Fe3O4@poly­(vinylpyrrolidone) (Fe3O4@PVP) endowed the nanocomposites with excellent cell imaging and photothermal functions. In addition, the surface modification of the composite nanoparticles with folic acid-grafted bovine serum albumin (FA–BSA) enables them to efficiently target tumor cells. Once FA–BSA/ZIF-8CNPs-CPT are taken up by tumor cells and irradiated with a near-infrared laser, the nanoparticles show a highly effective inhibitory effect against various tumor cells through a chemo-photothermal synergistic effect. Hence, it is conceivable that this acid-responsive multifunctional ZIF-8 nanocomposite has promising bioapplication prospects in cancer treatment

Supplementary document for Controllable transportation of microparticles along structured waveguides by plasmonic spin-hall effect - 5800701.pdf

Supplemental documen