92 research outputs found

    Experience of managing first fifty COVID-19 positive peripartum women in a tertiary care centre in North India

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    Background: SARS-CoV-2 has caused significant morbidity and mortality worldwide. Analysis of the clinical profile of COVID-19 positive pregnant women is important to understand the pathophysiology, transmission and outcome of the disease in Indian population.Methods: It is a retrospective observational study of first fifty pregnant patients tested positive for COVID-19 by qRT PCR admitted for delivery in our hospital.Results: In this audit, first fifty COVID-19 pregnant women were studied and the mean age of the patients in this study was 26 years. 98% of these women were admitted for obstetric indications. Seventy two percent of these women were admitted with spontaneous onset of labour. Based on disease severity, 49 (98%) were either asymptomatic or exhibited mild disease and only 1 (2%) had severe disease who succumbed to her illness. Forty six percent patients delivered vaginally and 54% required cesarean delivery. The most common indication for LSCS was fetal distress (43%). Eighteen percent had preterm delivery. Among the newborn babies, one died due to severe birth asphyxia. Sixteen percent babies required NICU stay. Five babies tested positive for COVID-19 of which one baby was positive on day one of life.Conclusions: As per our results, majority of the COVID-19 positive pregnant women had mild disease. There has been increase in cesarean section rate as compared to the previous hospital figures. Only one baby tested positive within 24 hours of delivery so the possibility vertical transmission can not be commented upon as of today

    Competition between antiferromagnetism and superconductivity, electron-hole doping asymmetry and "Fermi Surface" topology in cuprates

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    We investigate the asymmetry between electron and hole doping in a 2D Mott insulator, and the resulting competition between antiferromagnetism (AF) and d-wave superconductivity (SC), using variational Monte Carlo for projected wave functions. We find that key features of the T = 0 phase diagram, such as critical doping for SC-AF coexistence and the maximum value of the SC order parameter, are determined by a single parameter which characterises the topology of the "Fermi surface" at half filling defined by the bare tight-binding parameters. Our results give insight into why AF wins for electron doping, while SC is dominant on the hole doped side. We also suggest using band structure engineering to control the parameter for enhancing SC.Comment: 4 pages, 4 figure

    Carboxymethylation of Cysteines Impedes Aggregation of Hen Lysozyme in Alkaline pH

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    U wave: an Important Noninvasive Electrocardiographic Diagnostic Marker

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    Study of U waves exemplifies important clinical role of noninvasive electrocardiography in modern cardiology. Present article highlights significance of U waves with a clinical case and also summarizes in brief the history of the same

    Trends of Poisoning Cases in Tertiary Care Teaching Hospitals in Western Indian Population

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    Background: Any substance, which makes life better, if not used wisely and with proper care, would become dangerous to human life. These chemical substances can be termed poisons. A poison can be defined as a substance (solid, liquid, or gas), which if introduced into a living body or brought into contact with any part thereof would produce disease or even death by its constitutional or local effects or both. Pattern of poisoning in a particular region depends on various factors like availability and access to the poison, socioeconomic status of an individual, educational status, knowledge on pesticides, and their proper usage. In India, due to variations in geographical conditions and differences in religious and cultural practices, the incidence and pattern of poisoning vary from place to place, hence it is better to perform regional studies periodically to recognize the extent and evolution of the problem.Methods: This is a cross-sectional and observational study, which was conducted in tertiary care teaching institutes in Western India. The study includes 318 deceased persons due to poison consumption brought for postmortem examination. Results: Incidence of death due to poisoning was more in the third (31.7%) and second decade (22.6%) of life as compared to both extremes of age. The majority of victims were males (64.2%) as compared to females (35.8%). It was also observed that most victims belonged to lower socioeconomic class (58.8%) with educational status from illiteracy to primary education. Majority were farmers commonly due to insecticidal poisoning.Conclusion: Pattern of poisoning in the present study corresponds with the pattern found in most other studies. Majority of victims were male and agricultural poisons were the most common type. Our study suggests that establishment of poison information centers, availability of antidotes in rural area, and creating awareness among people help effectively to resolve the problem

    Clinical Profile and Outcomes of COVID-19 in Renal Transplant Recipients

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    There is minimal information on coronavirus disease 2019 (COVID-19) in developing countries regarding renal transplant recipients (RTRs). This paper aimed to study the clinical profile, immunosuppressive regimen, treatment, and outcomes in an RTR with COVID-19. This retrospective study was conducted in the nephrology department of Sri Aurobindo Medical College & Postgraduate Institute, Indore (MP), India, from April 1, 2020 to December 15, 2020. We studied 15 patients, of which 13 were treated at our hospital and two were treated in OPD. The median age of transplant recipients was 45 (Interquartile range [IQR]: 26–62) years, the majority being males, and recipients presented at a median of 4 (IQR: 0.3–11) years after transplant. The most common comorbidities included hypertension in 14 (94%) and diabetes 3 (20%) patients. The presenting symptoms at presentation were cough (80%), headache (52%), fever (46%), and breathlessness (26%). Clinical severity as per computerized tomography (CT) severity score ranged from mild (20%), moderate (53%), and severe (27%). Strategies to modify immunosuppressants included discontinuation of antimetabolites without changes in calcineurin inhibitors and steroids (100%). Antiviral therapy (Favipiravir and Remdesivir) was associated with better outcomes and reduced hospital stay. Risk factors for mortality included ABO-incompatibility, severity of disease, high Coronavirus Disease 2019 (COVID-19) Reporting and Data System (CO-RADS) score, allograft dysfunction before COVID-19 infection, acute kidney injury, elevated inflammatory markers, and intensive care unit/ventilator requirement. Overall patient mortality was 13.2%. Risk factor for mortality in COVID-19 positive with RTR appears to be ABO-incompatible transplant, having a previous history of rejection, and patient requiring ventilatory support

    Polydopamine-Enabled Biomimetic Surface Engineering of Materials:New Insights and Promising Applications

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    Surface modification is an important approach to modify the properties of materials. Numerous approaches have been adopted to tailor the properties of such materials, which have been proven successful at many scales and parameters. However, most of these techniques are often tedious, poorly adhesive, costly, sometimes hazardous, and surface-specific, hence cannot be extended on a large scale and all kinds of surfaces. These shortcomings have led to the emergence of new dopamine (DA) based green surface modification technique where a thin polydopamine (PDA) layer is deposited on surfaces through a facile polymerization of DA under alkaline conditions to enable the surface for various applications. This surface modification strategy has several advantages over other techniques in deposition processing under mild conditions, cost-effective and straightforward ingredients, and applicability to all kinds of surfaces regardless of their sizes, shapes, and types. Moreover, the PDA layer enhances the surface functionality. Therefore, it can serve as a versatile platform for various secondary reactions for a wide range of applications. Herein, the chemistry of DA is summarized and its polymerized form PDA for the modification of different families of materials’ surfaces with an emphasis on energy, environmental and biological applications.</p

    Computational Study Reliability of Diesel Engine through Electrical Assembly

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    Consistency of a system is the probability that, under defined operational and environmental conditions, the device can perform a specific function at the end over a specified time [Dinkar et al. 2018]. Reliability must be defined by definitive norm based on many variables, maximum of that may random [Bhardwaj et al. (2018)]. Reliability is arduous to scale, because no such tool is there to do this for specific machine. The reliability of the diverse units of complex machinery depends on their output process, the standard of the composites used in their design, operating conditions, etc. Despite these criteria the reliability of the system is very much related to diverse forms of uncertainty. The numerical assessment of ambiguities is therefore the starting point for a numerical assessment of reliability [Bhardwaj et al. (2019)]. The theory of probability is a concept concerned with the analysis of risk [Li, Y. - F et al. 2006]. Maintenance regulations can address issues pertaining to general maintenance, fix or dump laws, rules on emergency reporting, inventory control, supply of spare parts, etc. Such maintenance policies may be defined in advance and implementation decisions may be taken accordingly. The design process involves unit length assessments, research protocols, degree of automation as well as integrated redundancies, test time, specific test facilities and measures for safety; and so forth [Allan, T.M., 2012]. Performance is an attribute of reliability to reparable systems which accounts for the quality and service property of a component or device. ABC appraisal seeks to distinguish the item from each other and decide the importance of the element and the degree as required by company
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