Search for new physics via photon polarization of b→sγb \rightarrow s \gamma

We suggest a discriminant analysis of new physics beyond the standard model through a detection of photon polarization in a radiative B meson decay. This analysis is investigated in SUSY SU(5) GUT with right-handed neutrino and left-right symmetric models. New physics search via CP asymmetry in the same process are also evaluated in each model for comparison. We show that new physics can be found via detecting the photon polarization in a parameter space of TeV energy scale.Comment: 20 pages, 8 figures, v2:references added, v3:published versio

ALMA Observations of the Gravitational Lens SDP.9

We present long-baseline ALMA observations of the strong gravitational lens H-ATLAS J090740.0-004200 (SDP.9), which consists of an elliptical galaxy at $z_{\mathrm{L}}=0.6129$ lensing a background submillimeter galaxy into two extended arcs. The data include Band 6 continuum observations, as well as CO $J$=6$-$5 molecular line observations, from which we measure an updated source redshift of $z_{\mathrm{S}}=1.5747$. The image morphology in the ALMA data is different from that of the HST data, indicating a spatial offset between the stellar, gas, and dust component of the source galaxy. We model the lens as an elliptical power law density profile with external shear using a combination of archival HST data and conjugate points identified in the ALMA data. Our best model has an Einstein radius of $\theta_{\mathrm{E}}=0.66\pm0.01$ and a slightly steeper than isothermal mass profile slope. We search for the central image of the lens, which can be used constrain the inner mass distribution of the lens galaxy including the central supermassive black hole, but do not detect it in the integrated CO image at a 3$\sigma$ rms level of 0.0471 Jy km s$^{-1}$.Comment: Accepted for publication in ApJL; 6 pages, 2 figures, 3 table

Light energy allocation at PSII under field light conditions: How much energy is lost in NPQ-associated dissipation?

In the field, plants are exposed to fluctuating light, where photosynthesis occurs under conditions far from a steady state. Excess energy dissipation associated with energy quenching of chlorophyll fluorescence (qE) functions as an efficient photo-protection mechanism in photosystem II. PsbS is an important regulator of qE, especially for the induction phase of qE. Beside the regulatory energy dissipation, some part of energy is lost through relaxation of excited chlorophyll molecules. To date, several models to quantify energy loss through these dissipative pathways in PSII have been proposed. In this short review, we compare and evaluate these models for PSII energy allocation when they are applied to non-steady state photosynthesis. As a case study, an investigation on energy allocation to qE-associated dissipation at PSII under non-steady state photosynthesis using PsbS-deficient rice transformants is introduced. Diurnal and seasonal changes in PSII energy allocation in rice under natural light are also presented. Future perspective of studies on PSII energy allocation is discussed

Inveterate dysplasic HIP - a surgical treatment

We assessed 50 patients (57 hips) with Hip development Inveterate Dysplasia, divided into 2 groups, according to treatments applied. Group A was constituted of 20 patients (24 hips), 2 males and 18 females, with mean age = 65.92m in which preoperative traction was employed for 2-4 weeks, when a bloody reduction, a Salter or Chiari osteotomy and a shortening and rotating-varusing intertrochanteric osteotomy were performed. Group B was formed by 30 patients (33 hips), 1 male and 29 females, with mean age = 52.88m. In those, a diaphyseal femoral osteotomy for shortening, bloody reduction, and Salter or Chiari osteotomy were performed. For X-ray evaluation, the following were analyzed: the Wiberg angle, avascular necrosis; femoral head roundness; discrepancy between lower limbs. For clinical evaluation purposes, we assessed: pain, Trendelenburg, neurological test and range of motion. Clinically, we observed 14 (58.33%) good outcomes and 10 (41.67%) fair outcomes for Group A, and 23 (69.70%) good and 10 (30.30%) fair outcomes for Group B. On X-Ray, outcomes were regarded as good in 9 (37.50%), fair in 5 (20.83%) and bad in 10 (41.67%) for Group A, and good in 23 (69.70%), fair in 5 (15.15%), and bad in 5 (15.15%) patients of Group B. After a statistical analysis, we found better outcomes in Group B.Avaliamos 50 pacientes (57 quadris) com Displasia do desenvolvimento do Quadril Inveterada, divididos em 2 grupos de acordo com o tratamento aplicado. O grupo A foi constituído por 20 pacientes (24 quadris), 2 masculinos e 18 femininos, com média das idades = 65,92m nos quais a tração pré-operatória foi utilizada por 2-4 semanas, quando realizou-se a redução cruenta, a osteotomia de Salter ou a de Chiari e a osteotomia intertrocantérica de encurtamento e rotação-varização. O grupo B foi composto por 30 pacientes (33 quadris), 1 masculino e 29 femininos, com média das idades = 52,88m. Nestes, foi realizada uma osteotomia femoral diafisária para encurtamento, redução cruenta e osteotomia de Salter ou Chiari. Para a avaliação radiográfica analisamos: ângulo de Wiberg, necrose avascular, esfericidade da cabeça femoral; discrepância entre os membros inferiores. Para a avaliação clínica consideramos: dor, Trendelenburg, exame neurológico e arco de movimento. Observamos, clinicamente, 14(58,33%) bons resultados e 10(41,67%) regulares no grupo A e 23(69,70%) bons e 10(30,30%) regulares no B. Radiograficamente, foram considerados 9(37,50%) bons, 5(20,83%) regulares e 10(41,67%) maus resultados no grupo A e 23(69,70%) bons, 5(15,15%) regulares e 5(15,15%) maus resultados no B. Após análise estatística, observamos melhores resultados no grupo B.UNIFESP-EPM DOTUNIFESP-EPM programa de Pós-graduação em Ortopedia e TraumatologiaUNIFESP, EPM, DOTUNIFESP, EPM programa de Pós-graduação em Ortopedia e TraumatologiaSciEL

Treatment of forearm fractures in children and adolescents

OBJECTIVE: The treatment and the angular deviations tolerated in diaphyseal forearm fractures in children evoke divergent opinions in literature. In view of this controversy, we idealized this study to evaluate the preferred treatment methods for this injury, during the 39th Brazilian Congress on Orthopedics and Traumatology. METHODS: A total 759 questionnaires were answered (13% of total entrants). We addressed the general aspects of the study sample to obtain a profile of the orthopedic surgeons questioned. RESULTS: Two clinical subjects were presented, aged 12 (CASE 1) and 5 years old (CASE 2), along with radiographs depicting forearm diaphyseal fractures of these patients. Data was gathered and submitted to statistical analysis. The overall preferred treatment in CASE 1 was closed reduction and fixation with Kirschner wires (26%), while in case 2 it was closed reduction followed by plaster cast (46%). CONCLUSION: Among orthopedic surgeons less than 30 years old, the choice for less invasive treatments and greater acceptance of angular values prevailed in both cases. The traumatologists accepted lower angular values and tended towards more invasive treatments, particularly for CASE 2. On the other hand, the pediatric orthopedic surgeon prefers less invasive treatments and accepts greater angular deviations.OBJETIVO: O tratamento e os desvios angulares tolerados nas fraturas diafisárias do antebraço em crianças evoca opiniões divergentes na literatura. Frente a esta indefinição, idealizamos este trabalho com o objetivo de avaliar transversalmente os métodos terapêuticos preferenciais para esta lesão durante o 39º Congresso Brasileiro de Ortopedia e Traumatologia. MÉTODO: Foram respondidos 759 questionários (13% do total de inscritos). Abordamos os aspectos gerais da amostra estudada para traçar o perfil do ortopedista questionado. Foram expostas duas situações clínicas em indivíduos de 12 (CASO 1) e 5 anos (CASO 2), sendo apresentadas radiografias com fraturas do antebraço destes pacientes. Os dados obtidos foram compilados e submetidos à análise estatística. RESULTADO: O tratamento mais indicado no CASO 1 foi redução incruenta e fixação com fios de Kirschner (26%), enquanto no CASO 2 foi redução incruenta seguida de aparelho gessado (46%). CONCLUSÃO: Entre os ortopedistas com menos de 30 anos, a escolha por tratamentos menos invasivos e aceitação de maiores angulações prevaleceu para ambos os casos. Os traumatologistas aceitam menor angulação e tendem aos tratamentos invasivos, particularmente para o CASO 2. Já o ortopedista pediátrico opta por tratamentos menos invasivos e aceita maiores desvios angulares.Universidade Federal de São Paulo (UNIFESP) Departamento de Ortopedia e TraumatologiaUNIFESP, Depto. de Ortopedia e TraumatologiaSciEL

Femoral overgrowth following surgical treatment of long-established dysplasia of the hip

OBJECTIVE: To measure femoral overgrowth using radiographic scanning in patients with long-established Developmental Dysplasia of the Hip treated with femoral shaft shortening, open reduction and acetabuloplasty. METHODS: We studied 30 children (33 hips) submitted to surgical treatment including femoral shaft shortening, open reduction according to Scaglietti & Calandriello's procedure and Salter acetabuloplasty without preliminary traction. There were 29 females and 1 male, with mean age = 4 years and 5 months at the time of operation. According to Zionts & MacEwen's classification, 23 hips were classified as type III (69.6%), 5 (15.2%) as type I and 5 (15.2%) as type II. The average femoral shortening was 45.12 mm (range: 30.00 mm to 80.00 mm). The mean follow-up time was 10 years and 2 months (range: 2 years and 3 months to 18 years) and we noticed a mean femoral discrepancy of 13.48mm (range: 0.00 mm to 60.00 mm) using plain scanning images. RESULTS: All patients evolved to femoral overgrowth; in 18 cases (54.6%), the leg length discrepancy found was 30mm. Conclusion: We noticed a significantly decreased discrepancy of femurs after surgical treatment when compared to the measurements obtained during outpatient follow-up.OBJETIVO: Medir radiograficamente através de escanometria o hipercrescimento femoral em pacientes portadores de Displasia do Desenvolvimento do Quadril inveterada tratados cirurgicamente com encurtamento femoral, redução cruenta e acetabuloplastia. MÉTODOS: Avaliamos 30 crianças (33 quadris) submetidas à redução cruenta pela técnica de Scaglietti e Calandriello, ostectomia para encurtamento femoral e acetabuloplastia de Salter. Haviam 29 do sexo feminino e 1 do sexo masculino, com idade média de 4 anos e 5 meses na ocasião da cirurgia. De acordo com a classificação de Zionts e MacEwen, 23 (69,6%) quadris foram classificados como tipo III, 5 (15,2%) como tipo I e 5 (15,2%) como tipo II. O encurtamento femoral médio foi 45,12mm (variando de 30,00mm a 80,00mm). O tempo de seguimento médio foi de 10 anos e 2 meses. A discrepância femoral média mensurada nos escanogramas foi 13,48mm (variando de 0,00mm a 60,00mm) após acompanhamento mínimo de 2 anos e 3 meses. RESULTADOS: Todos os pacientes evoluíram com hipercrescimento sendo que em 18 (54,6%) casos a anisomelia observada foi 30mm. CONCLUSÃO: Observamos diminuição significante na diferença entre os comprimentos femorais após tratamento cirúrgico comparando com as medidas obtidas durante o seguimento ambulatorial.Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Departamento de Ortopedia e TraumatologiaUNIFESP, EPM, Depto. de Ortopedia e TraumatologiaSciEL

Gendered effects of Contagious Bovine Pleuropneumonia (CBPP) occurrence and control in a pastoral community in Ijara sub county, northeastern Kenya

a<p>Regression coefficient reported and p-value in parentheses,</p>b<p>SE in parentheses.</p

Evolution of the carrying angle of the elbow: a clinical and radiographic study

OBJECTIVE: This paper has the purpose of evaluate the elbow carrying angle by clinic and radiographic examination in normal children and determine the range of normality according to age from childhood to skeletal maturity and also check if there is a statistically significant difference between the clinical and radiographic measurements. METHODS: We evaluated 510 persons with ages varying from 1 to 18 years distributed in groups with 30 subjects according to the age group with 1-year interval. We performed radiographic examination of the elbow and measured the angle formed by the long axis of the humerus and ulna. The data were statistically analyzed using the student t-test. RESULTS: We determined a normal curve of the study population where there was an increase of this parameter with the progression of age. No statistically significant difference between the clinical and radiographic measures. CONCLUSION: The average of the elbow carrying angle was 12,78 ± 5,35 degrees for females and 11,20 ± 4,45 degrees for males. This values increase progressively from childhood until 16 years when we notice stabilization. There was no statistical difference between the clinical and radiographic measurements.OBJETIVO: Avaliar clínica e radiograficamente o ângulo de carregamento do cotovelo (ACC) determinando uma curva de normalidade de acordo com faixas etárias (da infância à maturidade esquelética) e comparar as medidas clínicas e radiográficas. MÉTODOS: Avaliamos 510 indivíduos (1020 cotovelos), com idades entre 1 e 18 anos, distribuídos em grupos de 30 conforme faixas etárias, com intervalo de 1 ano. Excluímos os portadores de: fraturas do cotovelo, sequelas, malformações, doenças genéticas, afecções inflamatórias e frouxidão ligamentar. Mensuramos clinicamente o ACC bilateralmente com goniômetro, onde obtivemos duas medidas por dois examinadores onde média destas foi considerada. Realizamos radiografias ântero-posteriores dos cotovelos e aferimos os ângulos formados pelos eixos do úmero e da ulna. Todos os dados foram analisados estatisticamente pelo teste t student. RESULTADOS: Determinamos uma curva de normalidade onde observamos aumento deste parâmetro conforme a progressão da idade. Não observamos diferença significante entre as medidas clínicas e radiográficas. CONCLUSÃO: A média do ângulo de carregamento para o sexo feminino foi 12,78º ± 5,35 e para o masculino 11,20º ± 4,45. Este valor aumenta progressivamente da infância até os 16 anos quando observamos estabilização. Não houve diferença estatística significante das medidas clínicas e radiográficas.Universidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

A novel PI3K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with A MEK inhibitor

The PI3K–AKT pathway is expected to be a therapeutic target for non-small cell lung cancer (NSCLC) treatment. We previously reported that a novel PI3K inhibitor iMDK suppressed NSCLC cells in vitro and in vivo without harming normal cells and mice. Unexpectedly, iMDK activated the MAPK pathway, including ERK, in the NSCLC cells. Since iMDK did not eradicate such NSCLC cells completely, it is possible that the activated MAPK pathway confers resistance to the NSCLC cells against cell death induced by iMDK. In the present study, we assessed whether suppressing of iMDK-mediated activation of the MAPK pathway would enhance anti-tumorigenic activity of iMDK. PD0325901, a MAPK inhibitor, suppressed the MAPK pathway induced by iMDK and cooperatively inhibited cell viability and colony formation of NSCLC cells by inducing apoptosis in vitro. HUVEC tube formation, representing angiogenic processes in vitro, was also cooperatively inhibited by the combinatorial treatment of iMDK and PD0325901. The combinatorial treatment of iMDK with PD0325901 cooperatively suppressed tumor growth and tumor-associated angiogenesis in a lung cancer xenograft model in vivo. Here, we demonstrate a novel treatment strategy using iMDK and PD0325901 to eradicate NSCLC